Efavirenz Inhibits the Human Ether-A-Go-Go Related Current (hERG) and Induces QT Interval Prolongation inCYP2B6*6*6Allele Carriers

Results From the IQ-CSRC Prospective Study Support Replacement of the Thorough QT Study by QT Assessment in the Early Clinical Phase

(2015) B Darpo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Population pharmacogenetic-based pharmacokinetic modeling of efavirenz, 7-hydroxy- and 8-hydroxyefavirenz

(2013) A.M. Abdelhady et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Impact of pharmacogenetics on CNS side effects related to efavirenz

(2013) Almudena Sánchez Martín et al.   PHARMACOGENOMICS

Induction of CYP2C19 and CYP3A Activity Following Repeated Administration of Efavirenz in Healthy Volunteers

(2012) V Michaud et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Antiretroviral Treatment of Adult HIV Infection

(2012) Melanie A. Thompson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Worldwide variation in human drug-metabolism enzyme genes CYP2B6 and UGT2B7: implications for HIV/AIDS treatment

(2012) Jing Li et al.   PHARMACOGENOMICS

hERG K+ Channels: Structure, Function, and Clinical Significance

(2012) Jamie I. Vandenberg et al.   PHYSIOLOGICAL REVIEWS

Liver Toxicity of Antiretroviral Drugs

(2012) Michelle Jones et al.   SEMINARS IN LIVER DISEASE

Contribution of N-Glucuronidation to Efavirenz EliminationIn Vivoin the Basal and Rifampin-Induced Metabolism of Efavirenz

(2011) Doo-Yeoun Cho et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efavirenz associated with cognitive disorders in otherwise asymptomatic HIV-infected patients

(2011) N. Ciccarelli et al.   NEUROLOGY

Efavirenz Primary and Secondary Metabolism In Vitro and In Vivo: Identification of Novel Metabolic Pathways and Cytochrome P450 2A6 as the Principal Catalyst of Efavirenz 7-Hydroxylation

(2010) E. T. Ogburn et al.   DRUG METABOLISM AND DISPOSITION

Presence of the CYP2B6 516G> T polymorphism, increased plasma Efavirenz concentrations and early neuropsychiatric side effects in South African HIV-infected patients

(2010) Verena Gounden et al.   AIDS Research and Therapy

HIV and Long QT syndrome—Cause or coincidence

(2007) R. Puri et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY