Article
Chemistry, Organic
Gargi Chakraborty, Rakesh Mondal, Amit Kumar Guin, Nanda D. Paul
Summary: In this study, a nickel-catalyzed sustainable synthesis method was utilized to prepare a variety of five-membered fused nitrogen heterocycles, including benzimidazole, purine, benzothiazole, and benzoxazole. This was achieved through acceptorless dehydrogenative functionalization of alcohols and borrowing hydrogen approach, using a bench stable, easy to prepare, and inexpensive Ni(ii)-catalyst. Control experiments were conducted to elucidate the reaction mechanism.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Shruti Verma, Shelly Kujur, Richa Sharma, Devendra D. Pathak
Summary: A new nanocomposite was designed and characterized for the synthesis of pharmaceutically important quinazolines. The nanocomposite, serving as a heterogeneous catalyst, showed high yields and turnover numbers in the acceptorless dehydrogenative coupling reaction. This is the first report on the use of a heterogeneous catalyst for the ADC reaction between alcohols and nitriles to afford quinazolines.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Organic
Tamilthendral Veerappan, Ramesh Rengan
Summary: A sustainable synthesis of substituted pyrazoles is achieved via an eco-friendly dehydrogenative annulation reaction using newly synthesized binuclear Ru-(II) p-cymene complexes. The reaction proceeds under mild conditions, producing H(2)O/H-2 as the only byproduct, and yields a range of polysubstituted pyrazoles and a therapeutic gout medicine analogue successfully.
Article
Chemistry, Multidisciplinary
Satyadeep Waiba, Kakoli Maji, Mamata Maiti, Biplab Maji
Summary: In this study, we present a simple synthesis method for valuable alpha-hydroxycarboxylic acid molecules through an acceptorless dehydrogenative coupling of ethylene glycol and primary alcohols. A stable manganese complex catalyst facilitated the reaction, which showed scalability and high yields with excellent selectivities under mild conditions. The protocol is environmentally friendly, generating only water and hydrogen gas as byproducts. Furthermore, it was successfully applied to synthesize various drugs and bioactive molecules, demonstrating its broad applicability and potential in organic synthesis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Organic
Milan Maji, Dibyajyoti Panja, Ishani Borthakur, Sabuj Kundu
Summary: This review summarizes recent advances in the synthesis of heterocycles using the ADC approach, which involves transition metal-catalyzed acceptorless dehydrogenative coupling using alcohols as greener substrates. Homogeneous and heterogeneous catalysis are both discussed in this review, showcasing environmentally benign methodologies for producing N-heterocycles.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Organic
Nandita Biswas, Dipankar Srimani
Summary: The Ru-catalyzed reaction provides an economical and simple operational strategy for synthesizing biologically active 1,8-dioxodecahydroacridine derivatives with a wide substrate scope and good tolerance toward various functional groups.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Nihal S. Tabasi, Sertac Genc, Derya Gulcemal
Summary: An acceptorless dehydrogenative coupling of primary alcohols to carboxylic acids/carboxylates, esters, and Guerbet alcohols was developed under aerobic conditions using an N-heterocyclic carbene iridium(i) catalyst. The selectivity of the products can be easily adjusted by modifying reaction conditions such as catalyst and base amounts, choice of base, and reaction temperature.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Organic
Aswathi Ravindran, Maheepal Yadav, Manoharan Muthu Tamizh, Nattamai Bhuvanesh, Sunandan Sarkar, Ramasamy Karvembu
Summary: A series of Ru(II)-p-cymene complexes based on ferrocene-hydrazone were investigated for their catalytic activity in acceptorless dehydrogenative coupling (ADC) reactions. The Ru(II)-p-cymene isonicotinic Fc-hyrazone complex showed better performance in the solvent-free synthesis of 1,2-disubstituted benzimidazoles (up to 88%) and quinazolinones (up to 95%). The catalytic experiments demonstrated good to moderate yields, with hydrogen and water as the only by-products.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Ramin Rabbani, Sima Saeedi, Md Nazimuddin, Hector Barbero, Nathalie Kyritsakas, Travis A. White, Eric Masson
Summary: A cucurbit[8]uril-secured platinum terpyridyl chloride dimer was utilized as a photosensitizer and hydrogen-evolving catalyst for the photoreduction of water, leading to significantly higher volumes of produced hydrogen compared to free platinum or cucurbit[7]uril-bound platinum monomer. Density functional theory calculations demonstrated that the thermodynamics of the proton-coupled electron transfer promoted by CB[8] secure the Pt(ii)-Pt(ii) dimer in a reactive conformation, ultimately facilitating hydrogen formation.
Article
Chemistry, Multidisciplinary
Mingshi Pan, Xiabin Wang, Yixin Tong, Xiaodong Qiu, Xiaobao Zeng, Biao Xiong
Summary: A new strategy for the direct synthesis of functionalized pyrroles from beta-amino alcohols and ynones has been demonstrated. This method proceeds in an atom- and step-economic fashion and offers the advantages of broad substrate scope, operational simplicity, and water and hydrogen gas as the sole by-products, providing an alternative and sustainable path to access functionalized pyrroles.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Savarimuthu Selvan Clinton, Rengan Ramesh, Jan Grzegorz Malecki
Summary: The catalytic application of new orthometallated palladium(II) C-S pincer complexes has been reported for the synthesis of bis(indolyl)methanes using alcohols as feedstocks. The complexes were synthesized using [PdCl2(PPh3)(2)] and thiourea ligand derivatives, and characterized using various techniques. The complexes showed excellent catalytic activity and tolerance towards a wide range of substrates, resulting in high yields of bis(indolyl)methanes. The protocol also demonstrated the synthesis of biologically important compounds. Rating: 9 out of 10.
CATALYSIS SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Aswathi N. E. Ravindran, Dharmalingam Sindhuja, Nattamai Bhuvanesh, Ramasamy Karvembu
Summary: The catalytic activity of Ru(II)-arene complexes containing ferrocene thiosemicarbazone (Fc-TSC) ligands towards the selective synthesis of 1,2-disubstituted benzimidazoles via acceptorless dehydrogenative coupling of diamines with primary alcohols was investigated. The electronic effect of ligands on the catalytic activity of their complexes was studied, leading to the conclusion of achieving good to moderate yields in the synthesis of 1,2-disubstituted benzimidazoles.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Saranya Sundar, Ramesh Rengan, Anandaraj Pennamuthiriyan, David Semeril
Summary: A facile catalytic one-pot synthesis of N-acylhydrazones has been described using arene ruthenium (II) complexes. The method provides a wide range of N-acylhydrazones in good yields with high selectivity and functional group tolerance, without any alkylated products.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Wo Nie, Shichao Shen, Cheng Ma
Summary: A rhodium-catalyzed dehydrogenative cycloisomerization of dienylcyclopropane compounds is reported, providing a straightforward approach to highly substituted toluene derivatives in yields of 67-85%. The dienylcyclopropaneimides are produced through a single-step olefination procedure. Preliminary mechanistic studies suggest that an electron-withdrawing group as R is crucial for completing this transformation.
Article
Chemistry, Organic
Ye Jin, Min Li, Mao Liu, Qingmei Ge, Hang Cong, Zhu Tao
Summary: In this study, a selective pinacol rearrangement of hydrobenzoin compounds was achieved through a heterogeneous catalysis strategy in the presence of cucurbit[7]uril. Unexpectedly, the ketone was generated as the sole product under optimized conditions due to the cucurbit[7]uril-controlled hydride migration. The catalytic activity of cucurbit[7]uril was confirmed through five recycled runs. The experimental analysis and DFT calculation revealed the crucial role of supramolecular encapsulation in fixing the phenyl groups on hydrobenzoin compounds and triggering the hydride migration, leading to the preferential formation of ketone.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Shelly Kujur, Devendra Deo Pathak
RESEARCH ON CHEMICAL INTERMEDIATES
(2020)
Article
Chemistry, Applied
Samaresh Layek, Bhumika Agrahari, Rakesh Ganguly, Parthasarathi Das, Devendra D. Pathak
APPLIED ORGANOMETALLIC CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Archana Kumari, Sunidhi Singh, Kavita Parmar, Devendra Deo Pathak, Manis Kumar Jha
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2020)
Article
Chemistry, Applied
Akash Kumar, Shelly Kujur, Jyoti Prabha Kujur, Richa Sharma, Devendra Deo Pathak
Summary: In this study, a copper-triazine-dendrimer-functionalized graphene oxide (CTD-GO) catalyst was synthesized for the first time and its structure was confirmed using various techniques. The catalyst showed excellent catalytic activity and recyclability in the A(3)-coupling reaction in water.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Shelly Kujur, Shruti Verma, Devendra Deo Pathak
Summary: A new N-heterocyclic carbene (NHC) copper(I) complex supported on graphene oxide (GO-NHC-Cu) was synthesized and successfully used as a catalyst for the N-alkylation of anilines with alcohols under solvent-free and aerobic conditions, showing high catalytic activity and yields. The methodology is simple, green and efficient.
Article
Chemistry, Organic
Tathagata Choudhuri, Suvam Paul, Sourav Das, Devendra Deo Pathak, Avik Kumar Bagdi
Summary: An efficient visible-light-induced methodology using erythrosine B as the photocatalyst has been developed for the regioselective selenylation of pyrazolo[1,5-a]pyrimidine derivatives. The methodology has also been demonstrated to be efficient for selenylation of different electron-rich heterocycles. The use of erythrosine B as the photocatalyst, along with the simplicity of the procedure and the eco-friendly energy, oxidant, and solvent employed, are attractive characteristics of this methodology.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Shelly Kujur, Shruti Verma, Akash Kumar, Richa Sharma, Devendra Deo Pathak
Summary: A green polyol method was used to synthesize Cu2O nanoparticles immobilized on graphene oxide for the first time. The composition of the synthesized composite was characterized, and its catalytic application in the synthesis of pharmaceutically important heterocycles was investigated.
NEW JOURNAL OF CHEMISTRY
(2022)
Proceedings Paper
Materials Science, Multidisciplinary
Pankaj, Richa Sharma, Sudhir Kumar Verma
Summary: The removal of Disperse Orange 30 (DO 30) or Yellow Brown S2RFL Dye in aqueous solutions using TiO2 adsorption in the presence of ultrasound and rare earth ions has been reported. The adsorption data was best fitted with Langmuir isotherm, indicating the potential of TiO2 and La+3 / Gd+3 combination as a method for dye removal.
MATERIALS TODAY-PROCEEDINGS
(2021)
Article
Nanoscience & Nanotechnology
Shubham Biswas, Ha-Young Lee, Manohar Prasad, Abhishek Sharma, Jong-Sung Yu, Siddhartha Sengupta, Devendra Deo Pathak, Apurba Sinhamahapatra
Summary: This study presents a new approach to photoassisted hydrogen generation using a Ni-based cocatalyst with a small amount of Pt, which exhibits better charge separation efficiency and hydrogen generation rate compared to a Pt-only cocatalyst in the photodegradation of methanol-water.
ACS APPLIED NANO MATERIALS
(2021)