Article
Chemistry, Analytical
Min Qiao, Yuan Cao, Taihong Liu, Liping Ding, Yu Fang
Summary: The development of a dual-chromophore-based fluorescent probe enables the selective recognition of the anionic surfactant SDS among other types. By exhibiting extra rhodamine emission, the probe provides specific recognition patterns and two-dimensional scatter plots for differentiation of various anionic surfactants.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Physical
Jasvir Kaur, Jotiram N. Malegaonkar, Sidhanath Bhosale, Prabhat K. Singh
Summary: This study developed a biosensor based on aggregation induced emission for rapid and sensitive detection of trypsin and organophosphorous pesticides. By studying the AIE phenomenon of the Su-TPE/PrS system, the biosensor demonstrated excellent performance in detecting trypsin and organophosphorous pesticides with high sensitivity and selectivity.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biophysics
Prinjaporn Teengam, Narathorn Nisab, Natthaya Chuaypen, Pisit Tangkijvanich, Tirayut Vilaivan, Orawon Chailapakul
Summary: A novel fluorescent paper-based DNA sensor using acpcPNA probe was developed for sensitive and selective detection of HCV. The sensor demonstrated great potential for clinical point-of-care applications, with successful application in clinical samples.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Plant Sciences
Manon Genva, Louise Fougere, Delphine Bahammou, Sebastien Mongrand, Yohann Boutte, Laetitia Fouillen
Summary: Anionic phospholipids play important roles in cell signaling, membrane trafficking, and cell differentiation processes. Developing a sensitive and accurate method to detect and quantify anionic phospholipids is crucial. In this study, researchers developed a method based on HPLC and two-dimensional mass spectrometry to detect and quantify all molecular species of anionic phospholipids in one shot. They also discovered that anionic phospholipids in the roots of Arabidopsis thaliana are enriched with very long chain fatty acids.
Article
Chemistry, Analytical
Teerapong Jantarat, Surachada Chuaychob, Chongdee Thammakhet-Buranachai, Panote Thavarungkul, Proespichaya Kanatharana, Wisarut Srisintorn, Chittanon Buranachai
Summary: A label-free and sensitive fluorescent sensor based on Gquadruplex and Thioflavin T was developed for cisplatin detection in urine samples, showing high accuracy and precision. The sensor performance was influenced by various parameters including pH, buffer concentration, type and number of GQ, with a linear dynamic range of 10-500 nM. The sensor successfully quantified cisplatin levels with a limit of quantification at 10 nM.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Chemistry, Inorganic & Nuclear
Daniel A. McNaughton, Mohamed Fares, Giacomo Picci, Philip A. Gale, Claudia Caltagirone
Summary: This review presents recent developments in fluorescent and colorimetric anion sensors, utilizing various non-covalent interactions and advancements in anion-selective chemodosimeters.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Hao Guo, Yinsheng Liu, Ning Wu, Liping Peng, Xiaoqin Wei, Zongyan Lu, Zhiguo Yu, Wu Yang
Summary: A triazine-based fluorescent COF (MaTa-COF) with a large BET-specific surface area was synthesized and used as a highly sensitive Fe3+ fluorescent probe. The probe demonstrated a wide linear range and a low detection limit, as well as good recyclability performance.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Spectroscopy
Shuaibing Yu, Yan Li, Lei Gao, Peiran Zhao, Lei Wang, Lianzhi Li, Ying-Wu Lin
Summary: A novel ratiometric fluorescent sensor for Zn2+ was developed based on a zinc finger-like peptide, showing highly selective and sensitive response with a low detection limit and low biotoxicity.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Applied
Maolin Wang, Tingwen Wei, Long Jiang, Jing Wang, Yajing Li, Wenyan Wu, Xiaojian Huang, Fang Wang, Sheng Lu, Xiaoqiang Chen
Summary: In this study, a novel naphthalimide derivative, NDGF, was discovered to undergo decomposition under different intensities of UV light, resulting in corresponding fluorescence intensities. Furthermore, NDGF was prepared as a UV-responsive film NDGF-PEO, showing excellent competence in quantifying UV intensity. This discovery has great potential to advance the development of naphthalimide-based photocages and novel UV quantitative sensors.
Article
Chemistry, Physical
Roman V. Rodik, Sergiy O. Cherenok, Viktoriia Y. Postupalenko, Sule Oncul, Vladyslava Brusianska, Petro Borysko, Vitaly I. Kalchenko, Yves Mely, Andrey S. Klymchenko
Summary: This study reports on the self-assembly behavior of anionic amphiphilic calixarenes in aqueous media. The calixarenes with phosphonate groups and alkyl chains can form micelles of about 10 nm diameter and complex cationic peptides into nanoparticles. Cellular studies show that these anionic amphiphilic calixarenes have low cytotoxicity and enable the internalization of fluorescently labeled peptides into live cells.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Engineering, Environmental
Pramod Kumar Mehta, Jongyong Jeon, Ki Ryu, See-Hyoung Park, Keun-Hyeung Lee
Summary: Ratiometric fluorescent peptidyl probe was synthesized and used for quantifying Pb(II) in aquatic environment and live cells. The probe displayed high selectivity and sensitivity towards Pb(II), with cell-permeability and rapid response. The study revealed that the probe formed a complex with Pb(II) and formed red-emissive nanoparticles and fibrils.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemical Research Methods
Sorour Ramezanpour, Hamed Barzinmehr, Pezhman Shiri, Chris Meier, Seyed Abdulmajid Ayatollahi, Mehrdad Mehrazar
Summary: Two novel fluorescent peptide-based chemosensors, A and B, show excellent selectivity and sensitivity towards Al3+ ions with detection limits of 155 nM and 195 nM respectively. They form a 1:1 coordination complex with Al3+ and produce turn-on responses through an intramolecular charge transfer mechanism.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Yu-Hui Luo, A-Di Xie, Ming-Gai Hu, Ji Wu, Dong-En Zhang, Ya-Qian Lan
Summary: Anionic metal-organic frameworks with enhanced electrostatic interactions are synthesized, showing potential for absorption, separation, and selective sensing of ionic molecules. Two mesoporous anionic MOFs, JOU-11 and JOU-12, exhibit promising applications in absorbing and separating cationic organic dyes, as well as selectively sensing Fe3+, Cu2+, and Co2+ ions through fluorescence processes.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Analytical
Yuanqiang Hao, Ting Li, Lijie Luo, Shengnan Fan, Song Chen, Yintang Zhang, Zilong Tang, Maotian Xu, Rongjin Zeng, Shu Chen
Summary: The study introduced a dual-modal probe (DMP) capable of fluorescence and photoelectrochemical detection of thiophenol (TP), demonstrating high specificity and sensitivity. DMP not only detects TP in water samples, but also enables fluorescence imaging of TP in living cells and PEC detection of TP in real water samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Yuanqiang Hao, Ting Li, Lijie Luo, Shengnan Fan, Song Chen, Yintang Zhang, Zilong Tang, Maotian Xu, Rongjin Zeng, Shu Chen
Summary: This study presents a dual-modal probe that enables simultaneous fluorescence and photoelectrochemical detection of thiophenol (TP). The probe exhibits high specificity and sensitivity, allowing for fluorescence imaging of TP in living cells and PEC detection in real water samples. By incorporating a recognition moiety into a precursor molecule of a coumarin dye, the probe can react specifically with TP and generate a strong fluorescence emission and enhanced photoelectric effect.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Inorganic & Nuclear
Biswajit Santra, Vierandra Kumar, Pankaj Kalita, Vivek Gupta, Debdeep Mandal, Amitava Chandra, Mayank Joshi, Angshuman Roy Choudhury, Anukul Jana, Vadapalli Chandrasekhar
Article
Cell Biology
Shubham Kesarwani, Prakash Lama, Anchal Chandra, P. Purushotam Reddy, A. S. Jijumon, Satish Bodakuntla, Balaji M. Rao, Carsten Janke, Ranabir Das, Minhajuddin Sirajuddin
JOURNAL OF CELL BIOLOGY
(2020)
Review
Chemistry, Multidisciplinary
Rajasree Kundu, Amitava Chandra, Ankona Datta
Summary: Anionic phospholipids are essential structural components of cell membranes, with important roles in cell processes. Visualizing these phospholipids and their dynamics in living cells is crucial for disease therapy and diagnosis.
ISRAEL JOURNAL OF CHEMISTRY
(2021)
Editorial Material
Chemistry, Multidisciplinary
Anil Chandra, Saumya Prasad, Helena Iuele, Francesco Colella, Riccardo Rizzo, Eliana D'Amone, Giuseppe Gigli, Loretta L. del Mercato
Summary: This study presents a methodology for noncovalent HPTS immobilization on silica microparticles that takes into account the retention of pH sensitivity and the long-term stability of pH microsensors. The importance of surface charge in governing the sensitivity of the immobilized HPTS dye molecules on silica microparticles is emphasized, as well as assessing the immobilization methodology's preservation of sensitivity and stability of the microsensors.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Microbiology
Chaitra Prabhakara, Rashmi Godbole, Parijat Sil, Sowmya Jahnavi, Shah-e-Jahan Gulzar, Thomas S. van Zanten, Dhruv Sheth, Neeraja Subhash, Anchal Chandra, Akshatha Shivaraj, Patricia Panikulam, U. Ibrahim, Vijay Kumar Nuthakki, Theja Parassini Puthiyapurayil, Riyaz Ahmed, Ashaq Hussain Najar, Sai Manoz Lingamallu, Snigdhadev Das, Bhagyashri Mahajan, Praveen Vemula, Sandip B. Bharate, Parvinder Pal Singh, Ram Vishwakarma, Arjun Guha, Varadharajan Sundaramurthy, Satyajit Mayor
Summary: This study investigates the cellular mechanisms of SARS-CoV-2 entry into human cells and identifies Niclosamide as a potential inhibitor by inhibiting endosomal acidification. It suggests that drugs altering endocytic entry and acidification can assist in managing viral infections.
Article
Nanoscience & Nanotechnology
Anil Chandra, Saumya Prasad, Francesco Alemanno, Maria De Luca, Riccardo Rizzo, Roberta Romano, Giuseppe Gigli, Cecilia Bucci, Adriano Barra, Loretta L. del Mercato
Summary: This study presents a method to measure intracellular organelle pH in breast cancer cells using silica-based fluorescent microparticles. The research found similar acidification times but differences in heterogeneity between different cell lines. The novel computational approach allows for fast analysis of massive internalization events.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Cell Biology
Abhishek Chandra, Anthony B. Lagnado, Joshua N. Farr, Madison Doolittle, Tamara Tchkonia, James L. Kirkland, Nathan K. LeBrasseur, Paul D. Robbins, Laura J. Niedernhofer, Yuji Ikeno, Joao F. Passos, David G. Monroe, Robert J. Pignolo, Sundeep Khosla
Summary: This study demonstrates that cellular senescence-driven radiation-induced osteoporosis is primarily mediated by p21(Cip1) rather than p16(Ink4a), based on the clearance of senescent cells using genetic models. This approach may be used to investigate the contributions of these pathways in other senescence-associated conditions, including aging across tissues.
Article
Health Care Sciences & Services
Huseyin Naci, Ilias Kyriopoulos, William B. Feldman, Thomas J. Hwang, Aaron S. Kesselheim, Amitabh Chandra
Summary: Newly approved drugs are often subject to formulary exclusions and restrictions in Medicare Part D. Ensuring that formulary design is closely linked to the therapeutic value of drugs would improve patients' welfare.
Article
Medicine, General & Internal
Aritra Kumar Ray, Poulami Karmakar, Atanu Chandra, Sudip Kumar Ghosh, Partha Sarathi Karmakar
Summary: Polymyositis is an immune-mediated inflammatory myopathy characterized by symmetric weakness of proximal muscles. While generalised subcutaneous oedema is rare as a presenting feature of inflammatory myopathy, a case involving a young woman with this symptom was successfully diagnosed as polymyositis through detailed clinical evaluation and treatment with corticosteroids and azathioprine.
Article
Medicine, General & Internal
Uddalak Chakraborty, Arindam Santra, Alak Pandit, Souvik Dubey, Atanu Chandra
Summary: Millard-Gubler syndrome is a ventral pontine syndrome characterized by ipsilateral involvement of abducens and facial nerve with contralateral hemiparesis or hemiplegia. It can be caused by various etiologies, not just vascular brainstem syndrome. Tuberculosis is one possible cause of central nervous system involvement.
Article
Cardiac & Cardiovascular Systems
Katarina Yaros, Benay Eksi, Alvin Chandra, Kartik Agusala, Lorenz H. Lehmann, Vlad G. Zaha
Summary: Cardiovascular imaging plays an important role in the care of cancer patients, as they face increased risks of cardiovascular complications. Currently established imaging modalities are evolving towards increased specificity, while new modalities are emerging to target earlier stages of cardiovascular disease. Choosing suitable imaging modalities for individual patients is crucial for successful risk stratification. Future imaging tools have the potential to provide insights into the molecular pathology of cardiovascular complications associated with cancer and oncological therapies.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nivya Mendon, Rayees A. Ganie, Shubham Kesarwani, Drisya Dileep, Sarika Sasi, Prakash Lama, Anchal Chandra, Minhajuddin Sirajuddin
Summary: This study identified a nanobody called N1.2 that effectively blocks the entry of SARS-CoV-2 into human cells and exhibits stronger neutralizing effects against various pseudotyped viruses. The study used a nine-amino acid peptide from the receptor-binding motif of the spike protein as an epitope and demonstrated a rapid and efficient methodology for screening nanobodies against potential pathogenic targets. This approach has the potential to be used for targeting other viruses and pathogens as well.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Primary Health Care
Vinod Ashok Chaudhari, Siddhartha Das, Swaroop Kumar Sahu, Gerard Pradeep Devnath, Ankit Chandra
Summary: This study investigated the sociodemographic profile, pattern, and reasons for fatal suicidal poisoning in India. The findings revealed that fatal suicidal poisoning was more common among males, young adults, married individuals, agriculture workers/laborers, and in rural settings. The most commonly used poison was organophosphates, and family problems were the most common reason for suicide.
JOURNAL OF FAMILY MEDICINE AND PRIMARY CARE
(2022)