Journal
PLANTS-BASEL
Volume 11, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/plants11081070
Keywords
Opuntia ficus-indica; endophytic Aspergillus niger; antimicrobial activity; multidrug-resistant bacteria; benzaldehyde derivatives; cristatumin B
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Funding
- Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia [PNURSP2022R93]
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Endophytic Aspergillus species were isolated from Opuntia ficus indica fruit peels, and compounds with antibacterial activity were obtained. Among them, cristatumin B showed excellent activity against Gram-negative resistant bacteria, while isotetrahydroauroglaucin exhibited tremendous activity against Gram-positive resistant strains.
Endophytic Aspergillus species represent an inexhaustible source for many medicinally important secondary metabolites. The current study isolated the endophytic Aspergillus niger (OL519514) fungus from Opuntia ficus indica fruit peels. The antibacterial activities were reported for both Aspergillus species and Opuntia ficus indica fruit peel extract. Extraction of the endophytic fungal metabolites using ethyl acetate and fractionation was performed, yielding dihydroauroglaucin (C1), isotetrahydroauroglaucin (C2), and cristatumin B (C3). Resistant bacterial strains were used to investigate the efficiency of the total fungal ethyl acetate extract (FEA) and the isolated compounds. FEA showed promising wide spectrum activity. (C3) showed excellent activity against selected Gram-negative resistant bacteria; However, (C2) exhibited tremendous activity against the tested Gram-positive resistant strains; conversely, (C1) possessed the lowest antibacterial activity compared to the two other compounds. An in silico virtual molecular docking demonstrated that cristatumin B was the most active antimicrobial compound against the selected protein targets. In conclusion, the active metabolites newly isolated from the endophytic fungus Aspergillus niger (OL519514) and present in plants' waste can be a promising antimicrobial agent against multidrug-resistant bacteria.
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