Mesenchymal Stem Cell-Derived Exosomes: Toward Cell-Free Therapeutic Strategies in Chronic Kidney Disease

Mesenchymal Stem Cell–Derived Exosomes: A Promising Biological Tool in Nanomedicine

(2021) Wumei Wei et al.   Frontiers in Pharmacology

Unlocking the Power of Exosomes for Crossing Biological Barriers in Drug Delivery

(2021) Rebekah Omarkhail Elliott et al.   Pharmaceutics

miR-155 Contributes to the Immunoregulatory Function of Human Mesenchymal Stem Cells

(2021) Yves-Marie Pers et al.   Frontiers in Immunology

Mesenchymal Stem Cell-Derived Exosomes Carry MicroRNA-125a to Protect Against Diabetic Nephropathy by Targeting Histone Deacetylase 1 and Downregulating Endothelin-1

(2021) Yan Hao et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Extracellular Vesicles as a Therapeutic Tool for Kidney Disease: Current Advances and Perspectives

(2021) Raphael Rodrigues Corrêa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular vesicles as a next-generation drug delivery platform

(2021) Inge Katrin Herrmann et al.   Nature Nanotechnology

The glomerular filtration barrier: a structural target for novel kidney therapies

(2021) Ilse S. Daehn et al.   NATURE REVIEWS DRUG DISCOVERY

miR-20a Overexpression in Adipose-Derived Mesenchymal Stem Cells Promotes Therapeutic Efficacy in Murine Lupus Nephritis by Regulating Autophagy

(2021) Shanshan Wei et al.   Stem Cells International

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Exosomal miRNA-215-5p Derived from Adipose-Derived Stem Cells Attenuates Epithelial–Mesenchymal Transition of Podocytes by Inhibiting ZEB2

(2020) Juan Jin et al.   Biomed Research International

Lupus nephritis

(2020) Hans-Joachim Anders et al.   Nature Reviews Disease Primers

Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine

(2020) Guida Bento et al.   Cells

Exosomes derived from hucMSC attenuate renal fibrosis through CK1δ/β-TRCP-mediated YAP degradation

(2020) Cheng Ji et al.   Cell Death & Disease

Therapeutic Use of Mesenchymal Stem Cell-Derived Exosomes: From Basic Science to Clinics

(2020) Carl Randall Harrell et al.   Pharmaceutics

Stem cells: a potential treatment option for kidney diseases

(2020) Dongwei Liu et al.   Stem Cell Research & Therapy

Human umbilical cord-derived mesenchymal stem cells prevent the progression of early diabetic nephropathy through inhibiting inflammation and fibrosis

(2020) E Xiang et al.   Stem Cell Research & Therapy

Immunosuppressive Property of MSCs Mediated by Cell Surface Receptors

(2020) Siyu Liu et al.   Frontiers in Immunology

Differential Wound Healing Capacity of Mesenchymal Stem Cell-Derived Exosomes Originated From Bone Marrow, Adipose Tissue and Umbilical Cord Under Serum- and Xeno-Free Condition

(2020) Diem Huong Hoang et al.   Frontiers in Molecular Biosciences

miRNA-146a Improves Immunomodulatory Effects of MSC-derived Exosomes in Rheumatoid Arthritis

(2020) Fataneh Tavasolian et al.   CURRENT GENE THERAPY

MicroRNA‑199a‑3p suppresses high glucose‑induced apoptosis and inflammation by regulating the IKKβ/NF‑κB signaling pathway in renal tubular epithelial cells

(2020) Ruimin Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

A Review of Exosomal Isolation Methods: Is Size Exclusion Chromatography the Best Option?

(2020) Karim Sidhom et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Comparison of the Effects of Mesenchymal Stem Cells with Their Extracellular Vesicles on the Treatment of Kidney Damage Induced by Chronic Renal Artery Stenosis

(2020) Crysthiane Saveriano Rubiao Andre Ishiy et al.   Stem Cells International

microRNA-199a-3p inhibits hepatic apoptosis and hepatocarcinogenesis by targeting PDCD4

(2020) Zhenyang Li et al.   Oncogenesis

Exosome engineering: Current progress in cargo loading and targeted delivery

(2020) Shengyang Fu et al.   NanoImpact

Mesenchymal stem cell derived-exosomes: a modern approach in translational medicine

(2020) Sepideh Nikfarjam et al.   Journal of Translational Medicine

Comprehensive proteomic analysis of exosomes derived from human bone marrow, adipose tissue, and umbilical cord mesenchymal stem cells

(2020) Zheng-gang Wang et al.   Stem Cell Research & Therapy

Improved loading of plasma derived-extracellular vesicles to encapsulate antitumor miRNAs

(2019) Margherita Alba Carlotta Pomatto et al.   Molecular Therapy-Methods & Clinical Development

Exosomes: biogenesis, biologic function and clinical potential

(2019) Yuan Zhang et al.   Cell and Bioscience

Exosome secreted from adipose-derived stem cells attenuates diabetic nephropathy by promoting autophagy flux and inhibiting apoptosis in podocyte

(2019) Juan Jin et al.   Stem Cell Research & Therapy

Stem cells: past, present, and future

(2019) Wojciech Zakrzewski et al.   Stem Cell Research & Therapy

Extracellular vesicles containing miR-146a attenuate experimental colitis by targeting TRAF6 and IRAK1

(2019) Hui Wu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Pros and Cons of Mesenchymal Stem Cell-Based Therapies

(2019) Aleksandra Musiał-Wysocka et al.   CELL TRANSPLANTATION

Renal Regenerative Potential of Extracellular Vesicles Derived from miRNA-Engineered Mesenchymal Stromal Cells

(2019) Marta Tapparo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impact of ET-1 and sex in glomerular hyperfiltration in humanized sickle cell mice

(2019) Malgorzata Kasztan et al.   CLINICAL SCIENCE

Stem Cell Therapies in Kidney Diseases: Progress and Challenges

(2019) Cinzia Rota et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A mouse model of renal fibrosis to overcome the technical variability in ischaemia/reperfusion injury among operators

(2019) Yu Guan et al.   Scientific Reports

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

(2019) Laura M. Doyle et al.   Cells

Unilateral Ureteral Obstruction as a Model to Investigate Fibrosis-Attenuating Treatments

(2019) Elena Martínez-Klimova et al.   Biomolecules

Exosomal microRNA‐16‐5p from human urine‐derived stem cells ameliorates diabetic nephropathy through protection of podocyte

(2019) Yu‐Rui Duan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The deacetylase sirtuin 6 protects against kidney fibrosis by epigenetically blocking β-catenin target gene expression

(2019) Juan Cai et al.   KIDNEY INTERNATIONAL

Immune modulation by mesenchymal stem cells

(2019) Wei Jiang et al.   CELL PROLIFERATION

Adipose Mesenchymal Cells-Derived EVs Alleviate DOCA-Salt-Induced Hypertension by Promoting Cardio-Renal Protection

(2019) Rafael Soares Lindoso et al.   Molecular Therapy-Methods & Clinical Development

Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases

(2019) Carl Randall Harrell et al.   Cells

Exosomal MicroRNA-10a Is Associated with Liver Regeneration in Rats through Downregulation of EphA4

(2018) Yong Zeng et al.   CHINESE MEDICAL JOURNAL

Regenerating the kidney using human pluripotent stem cells and renal progenitors

(2018) Francesca Becherucci et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Anti-fibrotic treatments: A review of clinical evidence

(2018) Marco Allinovi et al.   MATRIX BIOLOGY

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

(2018) Haiying Zhang et al.   NATURE CELL BIOLOGY

Urine-derived cells for human cell therapy

(2018) Nimshitha Pavathuparambil Abdul Manaph et al.   Stem Cell Research & Therapy

Effect of a Combination of Prednisone or Mycophenolate Mofetil and Mesenchymal Stem Cells on Lupus Symptoms in MRL.Faslpr Mice

(2018) Hong Kyung Lee et al.   Stem Cells International

Exploiting the impact of the secretome of MSCs isolated from different tissue sources on neuronal differentiation and axonal growth

(2018) Rita Catarina Assunção-Silva et al.   BIOCHIMIE

Therapeutic use of curcumin-encapsulated and curcumin-primed exosomes

(2018) Mohammad N. Oskouie et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mesenchymal Stem Cell-Derived Exosomes Ameliorated Diabetic Nephropathy by Autophagy Induction through the mTOR Signaling Pathway

(2018) Nesrine Ebrahim et al.   Cells

Tangential Flow Filtration for Highly Efficient Concentration of Extracellular Vesicles from Large Volumes of Fluid

(2018) Sara Busatto et al.   Cells

Autophagy: An Essential Degradation Program for Cellular Homeostasis and Life

(2018) Yoomi Chun et al.   Cells

Hypertensive Kidney Injury and the Progression of Chronic Kidney Disease

(2017) Karen A. Griffin   HYPERTENSION

Perfusion of isolated rat kidney with Mesenchymal Stromal Cells/Extracellular Vesicles prevents ischaemic injury

(2017) Marilena Gregorini et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy

(2017) Adeera Levin et al.   LANCET

Chronic Kidney Disease

(2017) Angela C Webster et al.   LANCET

Bone marrow-derived mesenchymal stem cells inhibit T follicular helper cell in lupus-prone mice

(2017) X Yang et al.   LUPUS

Concise Review: MSC-Derived Exosomes for Cell-Free Therapy

(2017) Donald G. Phinney et al.   STEM CELLS

Establishment and evaluation of a reversible two-kidney, one-clip renovascular hypertensive rat model

(2017) Li-Qiang Li et al.   Experimental and Therapeutic Medicine

Sirtuin 6 inhibits epithelial to mesenchymal transition during idiopathic pulmonary fibrosis via inactivating TGF-β1/Smad3 signaling

(2017) Kunming Tian et al.   Oncotarget

Adipose-derived mesenchymal stem cells employed exosomes to attenuate AKI-CKD transition through tubular epithelial cell dependent Sox9 activation

(2017) Fengming Zhu et al.   Oncotarget

A Systemic Review of Adult Mesenchymal Stem Cell Sources and their Multilineage Differentiation Potential Relevant to Musculoskeletal Tissue Repair and Regeneration

(2017) Rhiannon Nancarrow-Lei et al.   Current Stem Cell Research & Therapy

Focus on Mesenchymal Stem Cell-Derived Exosomes: Opportunities and Challenges in Cell-Free Therapy

(2017) Lin Cheng et al.   Stem Cells International

Non-coding RNAs in Mesenchymal Stem Cell-Derived Extracellular Vesicles: Deciphering Regulatory Roles in Stem Cell Potency, Inflammatory Resolve, and Tissue Regeneration

(2017) Farah Fatima et al.   Frontiers in Genetics

Extracellular matrix metalloproteinase inducer (EMMPRIN) is a potential biomarker of angiogenesis in proliferative diabetic retinopathy

(2016) Ahmed M. Abu El-Asrar et al.   ACTA OPHTHALMOLOGICA

Oxidant Mechanisms in Renal Injury and Disease

(2016) Brian B. Ratliff et al.   ANTIOXIDANTS & REDOX SIGNALING

Exosomes induce and reverse monocrotaline-induced pulmonary hypertension in mice

(2016) Jason M. Aliotta et al.   CARDIOVASCULAR RESEARCH

Mesenchymal Stem Cells Deliver Exogenous MicroRNA-let7c via Exosomes to Attenuate Renal Fibrosis

(2016) Bo Wang et al.   MOLECULAR THERAPY

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

Mesenchymal Stromal Cells Prevent Renal Fibrosis in a Rat Model of Unilateral Ureteral Obstruction by Suppressing the Renin-Angiotensin System via HuR

(2016) Marilena Gregorini et al.   PLoS One

Concise Review: Human Embryonic Stem Cells-What Have We Done? What Are We Doing? Where Are We Going?

(2016) Dusko Ilic et al.   STEM CELLS

Unveiling the Differences of Secretome of Human Bone Marrow Mesenchymal Stem Cells, Adipose Tissue-Derived Stem Cells, and Human Umbilical Cord Perivascular Cells: A Proteomic Analysis

(2016) Ana O. Pires et al.   STEM CELLS AND DEVELOPMENT

Mechanisms of mesenchymal stem/stromal cell function

(2016) Jeffrey L. Spees et al.   Stem Cell Research & Therapy

Exosomes secreted by human urine-derived stem cells could prevent kidney complications from type I diabetes in rats

(2016) Zhen-zhen Jiang et al.   Stem Cell Research & Therapy

Pluripotent Stem Cells: Current Understanding and Future Directions

(2016) Antonio Romito et al.   Stem Cells International

Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy

(2016) Irina Arutyunyan et al.   Stem Cells International

CCR2 Positive Exosome Released by Mesenchymal Stem Cells Suppresses Macrophage Functions and Alleviates Ischemia/Reperfusion-Induced Renal Injury

(2016) Bing Shen et al.   Stem Cells International

Unilateral Renal Ischemia-Reperfusion as a Robust Model for Acute to Chronic Kidney Injury in Mice

(2016) Nathalie Le Clef et al.   PLoS One

Mesenchymal stem cell therapy ameliorates diabetic nephropathy via the paracrine effect of renal trophic factors including exosomes

(2016) Kanna Nagaishi et al.   Scientific Reports

Safety and biodistribution study of bone marrow–derived mesenchymal stromal cells and mononuclear cells and the impact of the administration route in an intact porcine model

(2015) Tuomas Mäkelä et al.   CYTOTHERAPY

Using exosomes, naturally-equipped nanocarriers, for drug delivery

(2015) Elena V. Batrakova et al.   JOURNAL OF CONTROLLED RELEASE

Bone marrow stromal cells as immunomodulators. A primer for dermatologists

(2015) Krisztian Nemeth et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications

(2015) Sweta Rani et al.   MOLECULAR THERAPY

Sox9 Activation Highlights a Cellular Pathway of Renal Repair in the Acutely Injured Mammalian Kidney

(2015) Sanjeev Kumar et al.   Cell Reports

Epithelial-to-Mesenchymal Transition in Diabetic Nephropathy: Fact or Fiction?

(2015) Ivonne Loeffler et al.   Cells

Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

(2014) Charles P. Lai et al.   ACS Nano

New Insights Into Molecular Mechanisms of Diabetic Kidney Disease

(2014) Shawn S. Badal et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

Allogeneic mesenchymal stem cell transplantation for lupus nephritis patients refractory to conventional therapy

(2014) Fei Gu et al.   CLINICAL RHEUMATOLOGY

Molecular mechanisms of diabetic kidney disease

(2014) Kimberly Reidy et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular and molecular mechanisms in kidney fibrosis

(2014) Jeremy S. Duffield   JOURNAL OF CLINICAL INVESTIGATION

Pluripotent stem cells in regenerative medicine: challenges and recent progress

(2014) Viviane Tabar et al.   NATURE REVIEWS GENETICS

Exosomes/miRNAs as mediating cell-based therapy of stroke

(2014) Hongqi Xin et al.   Frontiers in Cellular Neuroscience

Extracellular Vesicle-Mediated Transfer of Genetic Information between the Hematopoietic System and the Brain in Response to Inflammation

(2014) Kirsten Ridder et al.   PLOS BIOLOGY

Characterization of human plasma-derived exosomal RNAs by deep sequencing

(2013) Xiaoyi Huang et al.   BMC GENOMICS

Risk of tumorigenicity in mesenchymal stromal cell–based therapies—Bridging scientific observations and regulatory viewpoints

(2013) Lisbeth Barkholt et al.   CYTOTHERAPY

Antineutrophil Cytoplasmic Antibody-Associated Renal Vasculitis Treated With Autologous Mesenchymal Stromal Cells: Evaluation of the Contribution of Immune-Mediated Mechanisms

(2013) Marilena Gregorini et al.   MAYO CLINIC PROCEEDINGS

Human Wharton’s jelly-derived mesenchymal stromal cells reduce renal fibrosis through induction of native and foreign hepatocyte growth factor synthesis in injured tubular epithelial cells

(2013) Tao Du et al.   Stem Cell Research & Therapy

Human umbilical cord blood-derived mesenchymal stem cells prevent diabetic renal injury through paracrine action

(2012) Jong Hee Park et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

A novel vascular clip design for the reliable induction of 2-kidney, 1-clip hypertension in the rat

(2011) Stephen P. Chelko et al.   JOURNAL OF APPLIED PHYSIOLOGY

Cellular and molecular mechanisms of renal fibrosis

(2011) Youhua Liu   Nature Reviews Nephrology

Functional Mesenchymal Stem Cells Derived From Human Induced Pluripotent Stem Cells Attenuate Limb Ischemia in Mice

(2010) Qizhou Lian et al.   CIRCULATION

Oxidative stress in obstructive nephropathy

(2010) Amélie Dendooven et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopy

(2010) Tian Tian et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Common pathophysiological mechanisms of chronic kidney disease: Therapeutic perspectives

(2010) José M. López-Novoa et al.   PHARMACOLOGY & THERAPEUTICS

Sox11 Is Expressed in Early Progenitor Human Multipotent Stromal Cells and Decreases with Extensive Expansion of the Cells

(2010) Benjamin L. Larson et al.   TISSUE ENGINEERING PART A

Exosomes: proteomic insights and diagnostic potential

(2009) Richard J Simpson et al.   Expert Review of Proteomics

Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs

(2009) Tian Sheng Chen et al.   NUCLEIC ACIDS RESEARCH

Concise Review: Wharton's Jelly-Derived Cells Are a Primitive Stromal Cell Population

(2007) Deryl L. Troyer et al.   STEM CELLS