IL-4/IL-13 Axis in Allergic Rhinitis: Elevated Serum Cytokines Levels and Inverse Association With Tight Junction Molecules Expression

Reduced occludin and claudin-7 expression is associated with urban locations and exposure to second-hand smoke in allergic rhinitis patients

(2021) Siti Muhamad Nur Husna et al.   Scientific Reports

The Role of CD40 in Allergic Rhinitis and Airway Remodelling

(2021) Ke-Jia Cheng et al.   MEDIATORS OF INFLAMMATION

Nasal Epithelial Barrier Integrity and Tight Junctions Disruption in Allergic Rhinitis: Overview and Pathogenic Insights

(2021) Siti Muhamad Nur Husna et al.   Frontiers in Immunology

Interplay Between the IL-33/ST2 Axis and Bone Marrow ILC2s in Protease Allergen-Induced IL-5-Dependent Eosinophilia

(2020) Emma Boberg et al.   Frontiers in Immunology

Zonula occludens and nasal epithelial barrier integrity in allergic rhinitis

(2020) Che Othman Siti Sarah et al.   PeerJ

Interleukin-13 Alters Tight Junction Proteins Expression Thereby Compromising Barrier Function and Dampens Rhinovirus Induced Immune Responses in Nasal Epithelium

(2020) Zhi-Qun Huang et al.   Frontiers in Cell and Developmental Biology

Novel roles for nasal epithelium in the pathogenesis of chronic rhinosinusitis with nasal polyps

(2019) M.E. Cornet et al.   RHINOLOGY

Synergy of Interleukin (IL)-5 and IL-18 in eosinophil mediated pathogenesis of allergic diseases

(2019) Hemanth Kumar Kandikattu et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Interleukin‐13: Targeting an underestimated cytokine in atopic dermatitis

(2019) Thomas Bieber   ALLERGY

Signaling Through gp130 Compromises Suppressive Function in Human FOXP3+ Regulatory T Cells

(2019) Khalid Bin Dhuban et al.   Frontiers in Immunology

The IL-4/IL-13 axis in skin fibrosis and scarring: mechanistic concepts and therapeutic targets

(2019) Julie K. Nguyen et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Non-hematopoietic STAT6 induces epithelial tight junction dysfunction and promotes intestinal inflammation and tumorigenesis

(2019) Yuli Lin et al.   Mucosal Immunology

Interleukin-4 and interleukin-13 as possible therapeutic targets in systemic sclerosis

(2019) Giulia Gasparini et al.   CYTOKINE

Down-regulation of Tet2 is associated with Foxp3 TSDR hypermethylation in regulatory T cell of allergic rhinitis

(2019) Lu Tan et al.   LIFE SCIENCES

The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages

(2018) Zsolt Czimmerer et al.   IMMUNITY

Efficacy and safety of dupilumab in perennial allergic rhinitis and comorbid asthma

(2018) Steven F. Weinstein et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Histamine and T helper cytokine–driven epithelial barrier dysfunction in allergic rhinitis

(2018) Brecht Steelant et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma

(2018) Klaus F. Rabe et al.   NEW ENGLAND JOURNAL OF MEDICINE

Benralizumab in the treatment of severe asthma: design, development and potential place in therapy

(2018) Corrado Pelaia et al.   Drug Design Development and Therapy

Breast Cancer-Derived Exosomes Alter Macrophage Polarization via gp130/STAT3 Signaling

(2018) Sunyoung Ham et al.   Frontiers in Immunology

Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes

(2018) Ilkka S. Junttila   Frontiers in Immunology

Non-redundant Functions of IL-6 Produced by Macrophages and Dendritic Cells in Allergic Airway Inflammation

(2018) Ekaterina O. Gubernatorova et al.   Frontiers in Immunology

Regulation of bronchial epithelial barrier integrity by type 2 cytokines and histone deacetylases in asthmatic patients

(2017) Paulina Wawrzyniak et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Decreased Expression of E-cadherin and ZO-1 in the Nasal Mucosa of Patients with Allergic Rhinitis: Altered Regulation of E-cadherin by IL-4, IL-5, and TNF-alpha

(2016) Hyun-Ji Lee et al.   American Journal of Rhinology & Allergy

T helper 2 and T follicular helper cells: Regulation and function of interleukin-4

(2016) Anupama Sahoo et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Role of interleukin-6 polymorphisms in the development of allergic rhinitis

(2016) N. Zhao et al.   GENETICS AND MOLECULAR RESEARCH

Impaired barrier function in patients with house dust mite–induced allergic rhinitis is accompanied by decreased occludin and zonula occludens-1 expression

(2016) Brecht Steelant et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Structural basis for DNA recognition by STAT6

(2016) Jing Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effector cell signature in peripheral blood following nasal allergen challenge in grass pollen allergic individuals

(2015) M. H. Shamji et al.   ALLERGY

miR-143 inhibits interleukin-13-induced inflammatory cytokine and mucus production in nasal epithelial cells from allergic rhinitis patients by targeting IL13Rα1

(2015) Yaoshu Teng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IL-5 production by resident mucosal allergen-specific T cells in an explant model of allergic rhinitis

(2015) I. Skrindo et al.   CLINICAL AND EXPERIMENTAL ALLERGY

FOXP1 suppresses immune response signatures and MHC class II expression in activated B-cell-like diffuse large B-cell lymphomas

(2015) P J Brown et al.   LEUKEMIA

Interleukin-4 and interleukin-13 compromise the sinonasal epithelial barrier and perturb intercellular junction protein expression

(2014) Sarah K. Wise et al.   International Forum of Allergy & Rhinology

Allergic diseases and asthma: a global public health concern and a call to action

(2014) Ruby Pawankar   World Allergy Organization Journal

Follow-up study in local allergic rhinitis shows a consistent entity not evolving to systemic allergic rhinitis

(2013) Carmen Rondón et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Impact of Allergic Rhinitis and Asthma on Human Nasal and Bronchial Epithelial Gene Expression

(2013) Ariane H. Wagener et al.   PLoS One

IL-6, IL-17 and STAT3: a holy trinity in auto-immunity?

(2012) Annalisa Camporeale   Frontiers in Bioscience-Landmark

Transcriptional regulation by STAT6

(2011) Shreevrat Goenka et al.   IMMUNOLOGIC RESEARCH

Allergic rhinitis

(2011) Alexander N Greiner et al.   LANCET

Genome-wide Profiling of Interleukin-4 and STAT6 Transcription Factor Regulation of Human Th2 Cell Programming

(2010) Laura L. Elo et al.   IMMUNITY

ToppGene Suite for gene list enrichment analysis and candidate gene prioritization

(2009) J. Chen et al.   NUCLEIC ACIDS RESEARCH

Cytokine regulation of tight junctions

(2008) Christopher T. Capaldo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

STAT6 Inhibits TGF-β1-mediated Foxp3 Induction through Direct Binding to theFoxp3Promoter, Which Is Reverted by Retinoic Acid Receptor

(2008) Hiromi Takaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Untangling the Complex Web of IL-4- and IL-13-Mediated Signaling Pathways

(2008) M. Wills-Karp et al.   Science Signaling