Article
Chemistry, Analytical
Xin Zhang, Xianghui Shi, Yong Pan, Juncheng Jiang
Summary: This study investigates the pyrolysis behavior of tert-butyl hydroperoxide (TBHP) through molecular dynamics simulations. The main pyrolysis products and reaction pathways are identified, and a detailed reaction mechanism is proposed. The calculated apparent activation energy agrees reasonably with experimental results. This research provides scientific guidance for the process safety of organic peroxides and the development of suppression technologies.
JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
(2022)
Article
Chemistry, Organic
Zhang Yunqian, Zhou Chenfan, Liu Gongqing
Summary: Phosphoroselenoates are widely used in organic synthesis and drug discovery. This study developed a new method for the synthesis of phosphoroselenoates through the oxidative coupling reaction of diselenides with phosphites using t-butyl hydroperoxide (TBHP) as an oxidant. The advantages of this method include mild reaction conditions, broad substrate scope, excellent yields, and the absence of transition metals and bases.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Thermodynamics
Wenlin Huang, Congjie Hong, Wuchuan Sun, Honghuan Wu, Zuohua Huang, Yingjia Zhang
Summary: In this study, tert-butyl hydroperoxide (TBHP) was investigated as an additive reactively enhancer to improve the auto-ignition of n-heptane. The results showed a nonlinear promotion effect of TBHP on the auto-ignition of n-heptane, with detonation caused by TBHP impacting the reflected shock temperature and pressure at high beginning temperatures. Addition of TBHP suppressed the negative temperature coefficient (NTC) behavior of first-stage ignition and strengthened the NTC behavior of ignition delay time (IDT). Analysis indicated that TBHP facilitated the quick production of OH and CH3 radicals, enhancing the reactivity of n-heptane and affecting the main exothermic reaction in the early period. This study highlights the potential of TBHP in regulating the combustion of hydrocarbon fuels and provides insights for efficient utilization in scramjet engines and micro internal combustion engines.
COMBUSTION AND FLAME
(2023)
Article
Microbiology
Shih-Jie Chen, Hung-Yu Shu, Guang-Huey Lin
Summary: This study showed that Acinetobacter baumannii ATCC 19606 harbors two sets of ohrR-ohr genes in chromosomal DNA and a pMAC plasmid. While the chromosomal ohrR-C-ohr-C genes act as the major system in protecting the bacteria from organic hydroperoxide stresses, the pMAC ohrR-p-ohr-p genes can provide a supplementary protective effect and their interaction may influence bacterial growth and virulence.
Article
Biochemistry & Molecular Biology
Mikhail G. Akimov, Elena V. Fomina-Ageeva, Polina V. Dudina, Ludmila A. Andreeva, Nikolay F. Myasoyedov, Vladimir V. Bezuglov
Summary: This study found that the peptide exhibited dose-dependent cytoprotective effects against oxidative stress induced by H2O2, tert-butyl hydroperoxide, and KCN, as well as proproliferative activity. Its mechanism of action involved modulation of proliferation-related NF-kappa B genes, stimulation of prosurvival NRF2-gene-related pathway, and reduction of apoptosis.
Article
Chemistry, Physical
Julia Bueker, Martin Muhler, Baoxiang Peng
Summary: This concept article provides a comprehensive overview of recent advances in selective oxidation of cyclohexene using heterogeneous transition metal-based catalysts and environmentally benign oxidants.
Article
Biochemistry & Molecular Biology
Woo Kwon Jung, Su-Bin Park, Hwa Young Yu, Yong Hwan Kim, Junghyun Kim
Summary: Esculetin, derived from coumarin, has been found to have antioxidant and anti-apoptotic effects. It improves cell viability and reduces apoptosis in HEK293 cells under t-BHP-induced oxidative stress. At the molecular level, esculetin regulates the expression of pro-apoptotic and anti-apoptotic factors.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Qifeng Ren, Wenfei Zhang, Ping Li, Jianli Zhou, Zhonghao Li, Yang Zhou, Ming Li
Summary: Necrosis of the femoral head (NFH) is an orthopedic disease associated with inadequate blood supply and increased intraosseous pressure. The present study revealed that the expression of osteoprotegerin (OPG) was significantly decreased in the femoral head of NFH patients, and overexpression of OPG reversed chondrocyte apoptosis induced by oxidative stress.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Daniela Giustarini, Aldo Milzani, Isabella Dalle-Donne, Ranieri Rossi
Summary: Glutathione (GSH) has special antioxidant properties due to its high concentration, ubiquity, and reactivity. In diseases where oxidative stress plays a role, GSH concentration is reduced, making cells more prone to damage. This review discusses strategies for increasing cellular GSH, including GSH itself, derivatives, activators, prodrugs, foods, and diets, as well as their mechanisms and advantages/disadvantages.
Article
Food Science & Technology
Selvakumari Ulagesan, Sathish Krishnan, Taek-Jeong Nam, Youn-Hee Choi
Summary: Exposure to t-BHP leads to cytotoxicity and oxidative stress. The Crassostrea gigas peptide, PEP-1, has protective and antioxidant effects on t-BHP-induced oxidative stress in HepG2 cells.
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Environmental Sciences
Vincenzo Quinzi, Giulia Orilisi, Flavia Vitiello, Valentina Notarstefano, Giuseppe Marzo, Giovanna Orsini
Summary: This study evaluated the potential detachment of microplastics (MPs) from clear orthodontic aligners due to mechanical friction in artificial saliva. The results showed that all tested aligners contained MPs, with the highest number found in the Arc Angel brand and the lowest in Invisalign. This study highlights the release of MPs from clear aligners and raises concerns about its impact on human health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Engineering, Environmental
Ning Li, Mengzhen Yuan, Guoju Cui, Jiale Xu, Xiuyi Li, Guowei Wang, Xiaolin Zhu, Chunyi Li
Summary: This study proposes a novel route using molecular oxygen for the green synthesis of di-tert-butyl peroxide (DTBP) from isobutane. MoO3 was demonstrated as the selective catalyst for this reaction, and the selectivity to DTBP was determined by the amount of surface Mo = O sites. Under optimized conditions, high oxygen conversion (>95%) and stable product selectivities (DTBP -20 wt%, TBHP -13 wt%) were achieved. This work provides an environmentally friendly method for utilizing C4 hydrocarbon resources and producing DTBP.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Fahimeh Abedini Bajgiran, Zeinab Khazaei Koohpar, Ali Salehzadeh
Summary: This study found that continuous exposure to lead induced apoptosis in testicular cells, caused oxidative stress, and decreased sperm quality and morphological changes in testis cells. However, NAC treatment showed protective effects on testicular tissue mainly through rebalancing of antioxidant capacity and downregulation of apoptosis-related genes.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Laryssa G. Barrozo, Lais R. F. M. Paulino, Bianca R. Silva, Efigenia C. Barbalho, Danisvania R. Nascimento, Miguel F. Lima Neto, Jose R. Silva
Summary: NAC, as an antioxidant, plays a crucial role in promoting GSH biosynthesis and regulating cell proliferation. Studies on in vitro culture, oocyte maturation, embryonic development, and cryopreservation show beneficial effects of NAC in protecting cells from oxidative stress damage.
ANIMAL REPRODUCTION SCIENCE
(2021)
Article
Chemistry, Analytical
Dezhi Yang, Qiulan Li, Qian Zhang, Yijie Wang, Hong Li, Sai Kumar Tammina, Yaling Yang
Summary: An Au-based nanozyme composite, AuNPs/Cu,I, was constructed using Cu,I-doped carbon dots as the reducing agent and nanozyme. It exhibited versatile enzyme-like activities and served as a surface-enhanced Raman spectroscopy enhancer.
Article
Optics
Travis W. Sawyer, Michaela Taylor-Williams, Ran Tao, Ruqiao Xia, Calum Williams, Sarah E. Bohndiek
Summary: Multispectral imaging is widely used in various applications, and multispectral filter arrays (MSFAs) play a crucial role in cost-effective and compact snapshot multispectral imaging. However, there are limitations in the current design and optimization methods for MSFAs. This article presents Opti-MSFA, a Python-based toolbox that offers centralized design and optimization of MSFAs, incorporating advanced spectral-spatial optimization algorithms and supporting user-defined datasets.
Article
Oncology
Isabel Quiros-Gonzalez, Michal R. Tomaszewski, Monika A. Golinska, Emma Brown, Laura Ansel-Bollepalli, Lina Hacker, Dominique-Laurent Couturier, Rosa M. Sainz, Sarah E. Bohndiek
Summary: The study suggests that photoacoustic tomography may provide an early indication of response or resistance to antiangiogenic therapy, clearly distinguishing between control, responding, and resistant tumors within just a few weeks of treatment.
Article
Chemistry, Physical
Halina Abramczyk, Jakub Maciej Surmacki, Beata Brozek-Pluska
Summary: This study presents a non-invasive approach to study the redox status of cytochromes in brain tumors and breast cancers using Raman spectroscopy in in vitro and in vivo models. The results show that the amount of reduced cytochrome is abnormally high in cancer cells and lower in normal cells. Additionally, mitochondrial dysfunction and alterations in chemical composition were detected through Raman imaging.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Oncology
Thierry L. L. Lefebvre, Emma Brown, Lina Hacker, Thomas Else, Mariam-Eleni Oraiopoulou, Michal R. R. Tomaszewski, Rajesh Jena, Sarah E. E. Bohndiek
Summary: Radiotherapy is an essential treatment for solid tumors, and the development of imaging techniques, such as photoacoustic imaging (PAI), has provided new possibilities for assessing treatment response. PAI can evaluate the tumor microenvironment and has the potential to detect resistance during radiotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Engineering, Biomedical
Lina Hacker, Heidrun Wabnitz, Antonio Pifferi, T. Joshua Pfefer, Brian W. Pogue, Sarah E. Bohndiek
Summary: This perspective paper discusses the lack of accepted standards and suitable phantoms for the technical validation of biophotonic instrumentation, emphasizing the need for standardization and criteria in this field. By reviewing literature and developments, the paper identifies unmet needs and proposes a set of criteria for the standardization of biophotonic instrumentation.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Acoustics
Emma L. Brown, Thierry L. Lefebvre, Paul W. Sweeney, Bernadette J. Stolz, Janek Grohl, Lina Hacker, Ziqiang Huang, Dominique-Laurent Couturier, Heather A. Harrington, Helen M. Byrne, Sarah E. Bohndiek
Summary: This study developed a pipeline for quantifying 3D vascular networks captured using mesoscopic photoacoustic imaging and demonstrated the accuracy and reliability of segmentation methods applied to deep and superficial vessels. The segmentation results of vessels derived from breast cancer patients compared favorably to immunohistochemistry.
Article
Acoustics
Janek T. Groehl, Lina K. Hacker, Ben Cox, Kris Dreher, Stefan Morscher, Avotra C. Rakotondrainibe, Francois E. Varray, Lawrence Yip, William Vogt, Sarah Bohndeik
Summary: Photoacoustic imaging is a promising modality for patient management, but the lack of uniformity in data formats hinders progress and collaboration. The International Photoacoustic Standardisation Consortium has developed a consensus data format and conversion tools to facilitate data exchange and comparison.
Review
Biochemical Research Methods
Michaela Taylor-Williams, Graham Spicer, Gemma Bale, Sarah E. Bohndiek
Summary: This paper provides a systematic overview of hemoglobin imaging and sensing. Various methods for analyzing hemoglobin oxygenation are reviewed and compared, with a focus on their ability to determine hemoglobin biomarkers. The paper also highlights key limitations in current technology and suggests routes for advancing the clinical use of hemoglobin oxygenation information.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Chemistry, Physical
Pawel Krzyczmonik, Marta Klisowska, Andrzej Leniart, Katarzyna Ranoszek-Soliwoda, Jakub Surmacki, Karolina Beton-Mysur, Beata Brozek-Pluska
Summary: The research aimed to develop a conductive composite material and an electrochemical enzyme sensor based on it. The conductive composite, consisting of poly(3,4-ethylenedioxy-thiophene-poly(4-lithium styrenesulfonic acid)/chitosan-AuNPs-glutaraldehyde, was created via electrochemical production. The sensor showed high catalytic activity towards the oxidation of polyphenols and could be used for their determination.
Article
Oncology
Halina Abramczyk, Jakub Maciej Surmacki
Summary: The multiple functions of cytochrome c go beyond respiration, apoptosis, ROS scavenging, and oxidation of cardiolipine. It is involved in the propagation of mitogenic signals and its redox status is regulated by retinoic acid. The study reveals the importance of retinoic acid in cellular processes and the role of cytochrome c in mitochondrial energy homeostasis.
Article
Chemistry, Multidisciplinary
Halina Abramczyk, Jakub Surmacki
Summary: This study investigates the impact of COVID-19 mRNA vaccine on human lung epithelial carcinoma cells using Raman spectroscopy and imaging. The results demonstrate that the vaccine reduces the concentration of cytochrome c, leading to a decrease in oxidative phosphorylation, reduced apoptosis, and decreased ATP production. Additionally, the vaccine increases lipid synthesis in lipid droplets and alters the biochemical composition temporarily.
Article
Multidisciplinary Sciences
Halina Abramczyk, Jakub Maciej Surmacki, Monika Kopec, Karolina Jarczewska, Beata Romanowska-Pietrasiak
Summary: This paper evaluates the oxidation and oxygenation effects in heme proteins using spectroscopy and imaging techniques. The study extends the current understanding of these effects and provides evidence for their strong coupling. The results also demonstrate the mechanism of electronic-vibrational coupling in the Q band splitting. The research has important implications for the role of heme proteins in maintaining biological functions.
SCIENTIFIC REPORTS
(2023)
Meeting Abstract
Biophysics
Lisa-Maria Needham, Judith Weber, Juan A. Varela, James W. B. Fyfe, Dung T. Do, Catherine K. Xu, David Klenerman, Christopher M. Dobson, Christopher A. Hunter, Sarah E. Bohndiek, Thomas N. Snaddon, Steven F. Lee
BIOPHYSICAL JOURNAL
(2022)
