Review
Cell & Tissue Engineering
Anusree Dey, Sheetal Uppal, Jayeeta Giri, Hari Sharan Misra
Summary: Understanding the mechanism of fate decision in stem cells is crucial for therapeutic applications. BRD4, as an epigenetic regulator, plays a key role in maintaining stem cell potency and controlling lineage commitment, making it a potential target for stem cell therapeutics.
Review
Medicine, Research & Experimental
Lai Jiang, Yiru Shen, Yajing Liu, Lei Zhang, Wei Jiang
Summary: This article reviews the progress in cell origins, biomaterials, and advanced technology for creating human islet organoids, and discusses their advantages, shortcomings, and future challenges.
Review
Anatomy & Morphology
Mohammad Reza Hashemzadeh, Mohammad Ehsan Taghavizadeh Yazdi, Mohammad Sadegh Amiri, Seyed Hadi Mousavi
Summary: Cardiovascular diseases are currently a major concern worldwide, causing a high rate of mortality. Conventional treatments mainly focus on protecting the heart from failure progression, while regenerative medicine in the heart includes both cellular and noncellular approaches. Noncellular approaches have benefits like exosome administration and utilizing miRNAs, but they are unable to reverse necrotic or ischemic myocardium, highlighting the importance of recruiting stem cells for regenerative therapy.
Article
Pharmacology & Pharmacy
Pawan Kumar Raghav, Zoya Mann, Swati Ahlawat, Sujata Mohanty
Summary: This article discusses the application of mesenchymal stem cells (MSCs) in nanotherapies and scaffold approaches in biomedicine. Nanocomposites are used to encapsulate MSCs or provide support for their growth, and have potential in wound healing, bone and cartilage engineering, cardiac disorders, and neurological disorders.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Fernando J. Aguilar-Ayala, Fernando J. Aguilar-Perez, Geovanny Nic-Can, Rafael Rojas-Herrera, Gabriela Chuc-Gamboa, David Aguilar-Perez, Beatriz A. Rodas-Junco
Summary: Biomaterials and stem cells are crucial in regenerative medicine, particularly in the development of autologous therapies. While progress has been made, challenges remain in understanding the characteristics of biomaterials and the molecular mechanisms regulating stem cell behavior.
APPLIED SCIENCES-BASEL
(2022)
Article
Engineering, Biomedical
Laurence Burroughs, Mahetab H. Amer, Matthew Vassey, Britta Koch, Grazziela P. Figueredo, Blessing Mukonoweshuro, Paulius Mikulskis, Aliaksei Vasilevich, Steven Vermeulen, Ian L. Dryden, David A. Winkler, Amir M. Ghaemmaghami, Felicity R. A. J. Rose, Jan de Boer, Morgan R. Alexander
Summary: In this study, a novel combinatorial chemistry-topography screening platform, the ChemoTopoChip, was used to identify materials suitable for bone regeneration by screening for human mesenchymal stem cell (hiMSCs) and human macrophage response. The results show that the materials selected through this platform can induce osteoinduction in hiMSCs and modulate macrophage phenotype, providing a materials-induced alternative to osteo-inductive supplements in bone-regeneration.
Article
Medicine, Research & Experimental
Kasra Moeinabadi-Bidgoli, Amirhesam Babajani, Ghasem Yazdanpanah, Behrouz Farhadihosseinabadi, Elham Jamshidi, Soheyl Bahrami, Hassan Niknejad
Summary: Cell-based therapy and stem cell-based regenerative medicine are new approaches for treating degenerative diseases, but face challenges in clinical practice. Preconditioning methods could improve the outcomes of stem cell therapy by enhancing cell resistance against the host environment and improving various biological aspects of cells.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Chemistry, Multidisciplinary
Parinaz Abdollahiyan, Fatemeh Oroojalian, Ahad Mokhtarzadeh
Summary: Tissue engineering in regenerative medicine utilizes cells, substrates, and physiologically active biomolecules to generate advanced therapeutic methods, while nanotechnology can accelerate tissue repair by providing dynamic three-dimensional nano-environments.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Biotechnology & Applied Microbiology
Yuan Ding, Yanjie Li, Zhongquan Sun, Xin Han, Yining Chen, Yao Ge, Zhengwei Mao, Weilin Wang
Summary: Human regenerative ability is limited, leading to the use of cell-derived biomaterials for tissue repair. Stem cells and other multipotent cells have been used for therapy, but the paracrine effect rather than cell differentiation is often the key driver of tissue repair. Nonliving cell-derived techniques like extracellular vesicles and cell membrane-based therapy are important for fulfilling the demand for tissue repair, offering safer and more controllable options.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Anatomy & Morphology
Giancarlo Tejeda, Andrew J. Ciciriello, Courtney M. Dumont
Summary: Stem cell therapies have the potential to repair and regenerate tissue in the central nervous system. However, low transplant survival remains a major obstacle. The use of biomaterials can significantly improve the survival of transplanted stem cells by providing protection and controlling the cytotoxic injury environment.
CELLS TISSUES ORGANS
(2023)
Review
Biotechnology & Applied Microbiology
Fumei He, Jinxiu Cao, Junyang Qi, Zeqi Liu, Gan Liu, Wenbin Deng
Summary: Inorganic nanomaterials have unique physical and chemical properties that can optimize the therapeutic effects of stem cell transplantation and influence stem cell differentiation. They can be used as vectors to transport substances that interfere with the fate of stem cells, due to their huge specific surface area and modifiability.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Cell Biology
Yu Fang, Angelina Olegovna Zekiy, Farhoodeh Ghaedrahmati, Anton Timoshin, Maryam Farzaneh, Amir Anbiyaiee, Seyed Esmaeil Khoshnam
Summary: Trib2 is a pseudo serine/threonine kinase that plays important roles in regulating key signaling pathways and cell fate determination.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Multidisciplinary Sciences
Joachim Hanna, Flavio Beke, Louise M. O'Brien, Chrysa Kapeni, Hung-Chang Chen, Valentina Carbonaro, Alexander B. Kim, Kamal Kishore, Timon E. Adolph, Mikkel-Ole Skjoedt, Karsten Skjoedt, Marc de la Roche, Maike de la Roche
Summary: The study implicates Hedgehog signaling in Th17 polarization and intestinal immunopathology, suggesting the potential therapeutic use of Hedgehog inhibitors in the treatment of inflammatory bowel disease.
NATURE COMMUNICATIONS
(2022)
Article
Cell & Tissue Engineering
Naruphong Phunikom, Nittaya Boonmuen, Pakpoom Kheolamai, Kanoknetr Suksen, Sirikul Manochantr, Chairat Tantrawatpan, Duangrat Tantikanlayaporn
Summary: Andrographolide (AP) has been shown to promote proliferation, osteogenic differentiation, and bone formation of placenta-derived mesenchymal stem cells. It may be an effective novel agent for improving placenta-derived MSCs and stem cell-based therapy for bone regeneration. The compound enhances Wnt/beta-catenin signaling and osteoblast-specific gene expressions, promoting bone formation and increasing osteocalcin levels.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Riccardo Ossanna, Sheila Veronese, Lindsey Alejandra Quintero Sierra, Anita Conti, Giamaica Conti, Andrea Sbarbati
Summary: Cell-based therapy has the potential to restore lost cells and promote regeneration in various human disorders. Stem cells, particularly pluripotent stem cells and recently discovered Muse cells, hold great promise for clinical medicine. Muse cells are pluripotent cells found in adult human mesenchymal tissues, offering advantages such as autologous treatment and avoidance of rejection issues in transplants. They have shown promising results in preclinical studies and could expand therapeutic applications in regenerative medicine.
Article
Gastroenterology & Hepatology
Fernando Bessone, Miren Garcia-Cortes, Inmaculada Medina-Caliz, Nelia Hernandez, Raymundo Parana, Manuel Mendizabal, Maria Schinoni, Ezequiel Ridruejo, Vinicius Nunes, Mirta Peralta, Genario Santos, Margarita Anders, Daniela Chiodi, Martin Tagle, Pedro Montes, Enrique Carrera, Marco Arrese, M. Isabel Lizarzabal, Ismael Alvarez-Alvarez, Estefania Caballano-Infantes, Hao Niu, Jose Pinazo, Maria R. Cabello, M. Isabel Lucena, Raul J. Andrade
Summary: HDS-hepatotoxicity in Latin America is increasing and mainly affects young women, showing hepatocellular injury and higher chance of death/liver transplantation.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Infectious Diseases
Carla C. Montenegro, T. Pershing Bustamante-Chauca, Cecilia Pajuelo Reyes, Miguel Bernal, Lizandro Gonzales, Rafael Tapia-Limonchi, Juan R. Tejedo, Stella M. Chenet
Summary: This study reports the outbreak of P. falciparum in native communities of Condorcanqui, Amazonas, highlighting the importance of timely identification and treatment of symptomatic and asymptomatic malaria cases for achieving malaria control and possible elimination in this area.
Review
Immunology
E. Eduardo Sanchez-Castro, Cecilia Pajuelo-Reyes, Rebeca Tejedo, Barbara Soria-Juan, Rafael Tapia-Limonchi, Etelvina Andreu, Ana B. Hitos, Franz Martin, Gladys M. Cahuana, Clara Guerra-Duarte, Thamyres C. Silva de Assis, Francisco J. Bedoya, Bernat Soria, Carlos Chavez-Olortegui, Juan R. Tejedo
Summary: Snakebite envenoming is a neglected global disease with limited treatment options, potentially leading to permanent sequelae from local damage. Using mesenchymal stromal cells or their cell-free products may induce skeletal muscle regeneration in snakebite victims, improving treatment outcomes. Applying MSCs-based therapies to snakebite victims holds promise for providing a safe and cost-effective treatment option for this neglected health issue, particularly in areas with limited healthcare resources.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Stella M. Chenet, Alan Oyarce, Jorge Fernandez, Rafael Tapia-Limonchi, Thomas Weitzel, Juan R. Tejedo, Venkatachalam Udhayakumar, Maria Isabel Jercic, Naomi W. Lucchi
Summary: This study identified a cluster of falciparum malaria cases in Chilean travelers returning from Nigeria, in which one patient experienced recrudescent malaria after oral treatment. Molecular analysis revealed mutations associated with atovaquone and proguanil resistance, highlighting the importance of molecular characterization in imported malaria cases.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Environmental Sciences
Franz Zirena Vilca, Nestor Cahui Galarza, Juan R. Tejedo, Walter Alejandro Zamalloa Cuba, Clara Nely Campos Quiroz, Valdemar Luiz Tornisielo
Summary: Puno in Peru is the largest producer of trout, but the use of antibiotics in aquaculture has led to contamination of surface water and potential impacts on public health. The presence of antibiotics in sediments, surface water, and fish tissues highlights the need for better management practices to protect aquatic ecosystems from the harmful effects of antibiotic residues.
JOURNAL OF GREAT LAKES RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Estefania Caballano-Infantes, Irene Diaz, Ana Belen Hitos, Gladys Margot Cahuana, Antonio Martinez-Ruiz, Barbara Soria-Juan, Rosario Rodriguez-Grinolo, Abdelkrim Hmadcha, Franz Martin, Bernat Soria, Juan R. Tejedo, Francisco Javier Bedoya
Summary: The study demonstrates that NO can mimic hypoxia response in human PSCs under normoxic conditions, enhancing their stemness properties and altering their metabolic profile, including upregulation of genes like HIF-1 alpha, HIF-2 alpha, NANOG, OCT-4, and increased expression of glycolysis and mitochondrial fusion regulators.
Article
Biology
Rocio Jimenez Galan, Elena Prado-Mel, Maria Antonia Perez-Moreno, Estefania Caballano-Infantes, Sandra Flores Moreno
Summary: Pembrolizumab monotherapy is the standard first-line treatment for advanced NSCLC patients with PD-L1 TPS >= 50%. However, real-world outcomes may be lower than those seen in clinical trials. In this study of 88 patients, ECOG PS ≥ 2 was associated with poorer pembrolizumab outcomes, underscoring the need for more objective tools to evaluate patients' PS. Further research is needed to confirm these results and improve treatment effectiveness for all patients.
Article
Parasitology
Clavel Diaz-Quevedo, Hugo Frias, Gladys M. Cahuana, Rafael Tapia-Limonchi, Stella M. Chenet, Juan R. Tejedo
Summary: The study revealed a high prevalence of fascioliasis in cattle, with a significant association found between the infection and the Brown Swiss breed, as well as female cattle over 30 months old. Molecular genetic studies using the NAD1 gene marker identified six haplotypes of Fasciola hepatica in infected livers, highlighting the importance of continued monitoring due to the high risk of transmission to humans.
PARASITOLOGY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Estefania Caballano-Infantes, Alberto Garcia-Garcia, Carlos Lopez-Gomez, Alejandro Cueto, Mercedes Robles-Diaz, Aida Ortega-Alonso, Flores Martin-Reyes, Ismael Alvarez-Alvarez, Isabel Arranz-Salas, Francisco Ruiz-Cabello, Isabel M. Lucena, Eduardo Garcia-Fuentes, Raul J. Andrade, Miren Garcia-Cortes
Summary: The study identified CD69+iNKT as a potential biomarker to assess liver fibrosis progression in NAFLD, while CD69+CD8+ T cells were identified as an important biomarker to distinguish DILI from NAFLD.
Article
Biochemistry & Molecular Biology
Carmen Salguero-Aranda, Amparo Beltran-Povea, Fatima Postigo-Corrales, Ana Belen Hitos, Irene Diaz, Estefania Caballano-Infantes, Mario F. Fraga, Abdelkrim Hmadcha, Franz Martin, Bernat Soria, Rafael Tapia-Limonchi, Francisco J. Bedoya, Juan R. Tejedo, Gladys M. Cahuana
Summary: This study reveals that EGR-1 plays a negative role in regulating Pdx1 expression in mESCs, and its binding to the Pdx1 promoter depends on the methylation level and acetylation state of its DNA binding site. Targeting EGR-1 at early stages may be important for directing pluripotent cells towards Pdx1-dependent cell lineages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
Enrique Eduardo Sanchez-Castro, Gladys M. Cahuana, Cesar J. Garcia-Rios, Clara Guerra-Duarte, Policarpio Chauca, Rafael Tapia-Limonchi, Stella M. Chenet, Bernat Soria, Carlos Chavez-Olortegui, Juan R. Tejedo
Summary: This study used data from the Global Burden of Diseases Study 2019 to estimate the impact of malaria in Peru from 1990 to 2019. The results showed a decrease in malaria-related deaths, disability-adjusted life years, and economic burden in recent years.
LANCET REGIONAL HEALTH-AMERICAS
(2022)