Sex Plays a Multifaceted Role in Asthma Pathogenesis

Female Reproductive Factors and the Risk of Bronchiectasis: A Nationwide Population-Based Longitudinal Study

(2022) Bumhee Yang et al.   Biomedicines

Hormone replacement therapy and risk of severe asthma exacerbation in peri-menopausal and post-menopausal women: 17-year national cohort study

(2021) Bright I. Nwaru et al.   Journal of Allergy and Clinical Immunology-In Practice

Benefits of Airway Androgen Receptor Expression in Human Asthma

(2021) Joe G Zein et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Targeting androgen-signaling in ILC2s protects from IL-33-driven lung inflammation, independently of KLRG1

(2021) Eve Blanquart et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Nanoparticle-Induced Airway Eosinophilia Is Independent of ILC2 Signaling but Associated With Sex Differences in Macrophage Phenotype Development

(2021) Jessica L. Ray et al.   JOURNAL OF IMMUNOLOGY

Type 2-High Severe Asthma with and without Bronchiectasis: A Prospective Observational Multicentre Study

(2021) Claudia Crimi et al.   Journal of Asthma and Allergy

Steroid-Resistant Asthma and Neutrophils

(2020) Takeshi Nabe   BIOLOGICAL & PHARMACEUTICAL BULLETIN

A thymic stromal lymphopoietin polymorphism may provide protection from asthma by altering gene expression

(2020) Amy Moorehead et al.   CLINICAL AND EXPERIMENTAL ALLERGY

A prenatally disrupted airway epithelium orchestrates the fetal origin of asthma in mice

(2020) Dimitra E. Zazara et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Link between Asthma and Bronchiectasis: State of the Art

(2020) Claudia Crimi et al.   RESPIRATION

Estrogen receptor‐α signaling increases allergen‐induced IL‐33 release and airway inflammation

(2020) Jacqueline‐Yvonne Cephus et al.   ALLERGY

Association between Two Single Nucleotide Polymorphisms of Thymic Stromal Lymphopoietin (TSLP) Gene and Asthma in Iranian Population

(2020) Maral Ranjbar et al.   Iranian Journal of Allergy Asthma and Immunology

Japanese guidelines for adult asthma 2020

(2020) Yoichi Nakamura et al.   ALLERGOLOGY INTERNATIONAL

Real-life effectiveness of mepolizumab in patients with severe refractory eosinophilic asthma and multiple comorbidities

(2020) Claudia Crimi et al.   World Allergy Organization Journal

Hormone replacement therapy and asthma onset in menopausal women: National cohort study

(2020) Syed A. Shah et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The impact of 17β-estradiol and progesterone therapy on peripheral blood mononuclear cells of asthmatic patients

(2020) Leila Nejatbakhsh Samimi et al.   MOLECULAR BIOLOGY REPORTS

Sex differences in M2 polarization, chemokine and IL-4 receptors in monocytes and macrophages from asthmatics

(2020) Mireya Becerra-Díaz et al.   CELLULAR IMMUNOLOGY

Progesterone-Related Immune Modulation of Pregnancy and Labor

(2019) Nishel M. Shah et al.   Frontiers in Endocrinology

Vitamin D and disease severity in bronchiectasis

(2019) S. Ferri et al.   RESPIRATORY MEDICINE

Orchestration between ILC2s and Th2 cells in shaping type 2 immune responses

(2019) Rama Krishna Gurram et al.   Cellular & Molecular Immunology

Trends and Predictors of Hospitalization after Emergency Department Asthma Visits among U.S. Adults, 2006-2014

(2019) Michelle P. Lin et al.   JOURNAL OF ASTHMA

Sex-associated TSLP-induced immune alterations following early-life RSV infection leads to enhanced allergic disease

(2019) Carrie-Anne Malinczak et al.   Mucosal Immunology

Sex Differences in IL-33-Induced STAT6-Dependent Type 2 Airway Inflammation

(2019) Hedi Zhao et al.   Frontiers in Immunology

Management of Severe Asthma: a European Respiratory Society/American Thoracic Society Guideline

(2019) Fernando Holguin et al.   EUROPEAN RESPIRATORY JOURNAL

Nationwide survey of the prevalence of wheeze, rhino-conjunctivitis, and eczema among Japanese children in 2015

(2019) Emi Morikawa et al.   ALLERGOLOGY INTERNATIONAL

Sex and gender analysis improves science and engineering

(2019) Cara Tannenbaum et al.   NATURE

The impact of comorbidities on severe asthma

(2019) Paola Rogliani et al.   CURRENT OPINION IN PULMONARY MEDICINE

The different faces of the macrophage in asthma

(2019) T. Anienke van der Veen et al.   CURRENT OPINION IN PULMONARY MEDICINE

Vascular mechanisms of testosterone: The non-genomic point of view

(2019) Margarida Lorigo et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Immunologic mechanisms in asthma

(2019) Tadech Boonpiyathad et al.   SEMINARS IN IMMUNOLOGY

Group 2 innate lymphocytes at the interface between innate and adaptive immunity

(2018) Martijn J. Schuijs et al.   Annals of the New York Academy of Sciences

Sex-based differences in CD103+ dendritic cells promote female-predominant Th2 cytokine production during allergic asthma

(2018) C. Masuda et al.   CLINICAL AND EXPERIMENTAL ALLERGY

CD40LG duplication-associated autoimmune disease is silenced by nonrandom X-chromosome inactivation

(2018) Carole Le Coz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Endogenous and exogenous sex steroid hormones in asthma and allergy in females: A systematic review and meta-analysis

(2018) Nicola McCleary et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Macrophage plasticity, polarization, and function in health and disease

(2018) Abbas Shapouri-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Macrophage polarization and allergic asthma

(2018) Arjun Saradna et al.   Translational Research

Role of airway epithelial barrier dysfunction in pathogenesis of asthma

(2018) Yasuhiro Gon et al.   ALLERGOLOGY INTERNATIONAL

The interplay between neuroendocrine activity and psychological stress-induced exacerbation of allergic asthma

(2018) Tomomitsu Miyasaka et al.   ALLERGOLOGY INTERNATIONAL

Age and gender associations with systemic corticosteroid-induced morbidity in asthma

(2018) Luke E. Barry et al.   Journal of Allergy and Clinical Immunology-In Practice

Sex Differences in Pulmonary Responses to Ozone in Mice: Role of the Microbiome

(2018) Youngji Cho et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The “one airway, one disease” concept in light of Th2 inflammation

(2018) Lisa Giovannini-Chami et al.   EUROPEAN RESPIRATORY JOURNAL

Testosterone Decreases House Dust Mite–Induced Type 2 and IL-17A–Mediated Airway Inflammation

(2018) Hubaida Fuseini et al.   JOURNAL OF IMMUNOLOGY

Gender-specific asthma phenotypes, inflammatory patterns and asthma control in a cluster analysis

(2018) Han-Pin Hsiao et al.   Journal of Allergy and Clinical Immunology-In Practice

Risk of asthma onset after natural and surgical menopause: Results from the French E3N cohort

(2018) Bobette Matulonga-Diakiese et al.   MATURITAS

Sex-Related Allergic Rhinitis Prevalence Switch from Childhood to Adulthood: A Systematic Review and Meta-Analysis

(2017) Mariona Pinart et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Diagnosis and Management of Asthma in Adults

(2017) Jennifer L. McCracken et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Human asthma is characterized by more IRF5+ M1 and CD206+ M2 macrophages and less IL-10+ M2-like macrophages around airways compared with healthy airways

(2017) Christina Draijer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma

(2017) Kelly Sweerus et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Androgen signaling negatively controls group 2 innate lymphoid cells

(2017) Sophie Laffont et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Testosterone Attenuates Group 2 Innate Lymphoid Cell-Mediated Airway Inflammation

(2017) Jacqueline-Yvonne Cephus et al.   Cell Reports

Allergen-induced Changes in Bone Marrow and Airway Dendritic Cells in Subjects with Asthma

(2016) Amani El-Gammal et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Alternative Macrophage Activation Is Increased in Asthma

(2016) Pierre-Olivier Girodet et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Respiratory syncytial virus infection activates IL-13–producing group 2 innate lymphoid cells through thymic stromal lymphopoietin

(2016) Matthew T. Stier et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Menopause as a predictor of new-onset asthma: A longitudinal Northern European population study

(2016) Kai Triebner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Origin, Localization, and Immunoregulatory Properties of Pulmonary Phagocytes in Allergic Asthma

(2016) Franziska Hoffmann et al.   Frontiers in Immunology

Impact of Age and Sex on Outcomes and Hospital Cost of Acute Asthma in the United States, 2011-2012

(2016) Joe G. Zein et al.   PLoS One

High Physiological Concentrations of Progesterone Reverse Estradiol-Mediated Changes in Differentiation and Functions of Bone Marrow Derived Dendritic Cells

(2016) Fangming Xiu et al.   PLoS One

Rates and Correlates of Relapse Following ED Discharge for Acute Asthma

(2015) Brian H. Rowe et al.   CHEST

Genomic architecture of asthma differs by sex

(2015) Tesfaye B. Mersha et al.   GENOMICS

Barrier Epithelial Cells and the Control of Type 2 Immunity

(2015) Hamida Hammad et al.   IMMUNITY

Asthma: Hospitalization Trends and Predictors of In-Hospital Mortality and Hospitalization Costs in the USA (2001-2010)

(2015) Bani Preet Kaur et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Estrogen and progesterone decrease let-7f microRNA expression and increase IL-23/IL-23 receptor signaling and IL-17A production in patients with severe asthma

(2015) Dawn C. Newcomb et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Postmenopausal hormone therapy and asthma-related hospital admission

(2015) Klaus Bønnelykke et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The 3 major types of innate and adaptive cell-mediated effector immunity

(2015) Francesco Annunziato et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

High IFN-γ and low SLPI mark severe asthma in mice and humans

(2015) Mahesh Raundhal et al.   JOURNAL OF CLINICAL INVESTIGATION

Cortisol Stress Response in Men and Women Modulated Differentially by the Mu-Opioid Receptor Gene Polymorphism OPRM1 A118G

(2015) William R Lovallo et al.   NEUROPSYCHOPHARMACOLOGY

CD8+ T Cells Mediate Female-Dominant IL-4 Production and Airway Inflammation in Allergic Asthma

(2015) Chihiro Ito et al.   PLoS One

Myeloid dendritic cells type 2 after allergen inhalation in asthmatic subjects

(2014) B. Dua et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Genome-wide interaction studies reveal sex-specific asthma risk alleles

(2014) Rachel A. Myers et al.   HUMAN MOLECULAR GENETICS

The Involvement of Glucocorticoids in Psychological Stress-Induced Exacerbations of Experimental Allergic Asthma

(2014) Kaori Okuyama et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Resident Alveolar Macrophages Suppress, whereas Recruited Monocytes Promote, Allergic Lung Inflammation in Murine Models of Asthma

(2014) Zbigniew Zasłona et al.   JOURNAL OF IMMUNOLOGY

Thymic stromal lymphopoietin (TSLP) secretion from human nasal epithelium is a function of TSLP genotype

(2014) C C K Hui et al.   Mucosal Immunology

Estradiol Increases Mucus Synthesis in Bronchial Epithelial Cells

(2014) Anthony Tam et al.   PLoS One

Clinical view on the importance of dendritic cells in asthma

(2013) Rohit Gaurav et al.   Expert Review of Clinical Immunology

Conventional and Monocyte-Derived CD11b+ Dendritic Cells Initiate and Maintain T Helper 2 Cell-Mediated Immunity to House Dust Mite Allergen

(2013) Maud Plantinga et al.   IMMUNITY

Asthma

(2013) Fernando D Martinez et al.   LANCET

The Relationship of Ambient Ozone and PM2.5Levels and Asthma Emergency Department Visits: Possible Influence of Gender and Ethnicity

(2012) Jo Ann Glad et al.   Archives of Environmental & Occupational Health

Global asthma prevalence in adults: findings from the cross-sectional world health survey

(2012) Teresa To et al.   BMC PUBLIC HEALTH

Age-related differences in clinical outcomes for acute asthma in the United States, 2006-2008

(2012) Chu-Lin Tsai et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Gene-environment interactions in asthma and allergic diseases: Challenges and perspectives

(2012) Francine Kauffmann et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Thymic stromal lymphopoietin is induced by respiratory syncytial virus–infected airway epithelial cells and promotes a type 2 response to infection

(2012) Hai-Chon Lee et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Asthma and the menopause: A systematic review and meta-analysis

(2012) E. Zemp et al.   MATURITAS

IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction

(2012) Makoto Kudo et al.   NATURE MEDICINE

Innate and adaptive immune responses in asthma

(2012) Stephen T Holgate   NATURE MEDICINE

Asthma in adults and its association with chronic rhinosinusitis: The GA2LEN survey in Europe

(2011) D. Jarvis et al.   ALLERGY

Revolution 9

(2011) Paul J. Bryce   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Sex Hormone–Dependent Regulation of Cilia Beat Frequency in Airway Epithelium

(2011) Raksha Jain et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Allergic Asthma: Influence of Genetic and Environmental Factors

(2011) Anil B. Mukherjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Estrogen Increases Nitric-Oxide Production in Human Bronchial Epithelium

(2011) E. A. Townsend et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Pulmonary CD103+ dendritic cells prime Th2 responses to inhaled allergens

(2011) H Nakano et al.   Mucosal Immunology

Gender Differences and Effect of Air Pollution on Asthma in Children with and without Allergic Predisposition: Northeast Chinese Children Health Study

(2011) Guang-Hui Dong et al.   PLoS One

TSLP polymorphisms are associated with asthma in a sex-specific fashion

(2010) G. M. Hunninghake et al.   ALLERGY

Early Menarche Predicts Incidence of Asthma in Early Adulthood

(2010) B. Al-Sahab et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Postmenopausal hormone therapy and asthma onset in the E3N cohort

(2010) I. Romieu et al.   THORAX

Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program

(2009) Wendy C. Moore et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Activity and intracellular location of estrogen receptors α and β in human bronchial epithelial cells

(2009) Margarita M. Ivanova et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

An Analysis of Factors that Exacerbate Asthma, Based on a Japanese Questionnaire

(2009) Kumiko Koyanagi et al.   ALLERGOLOGY INTERNATIONAL

Cluster Analysis and Clinical Asthma Phenotypes

(2008) Pranab Haldar et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Gene by Environment Interaction in Asthma

(2008) Stephanie J. London et al.   Annual Review of Public Health

Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages

(2008) Elena Goleva et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CD8+ T cells in asthma: Friend or foe?

(2008) Richard J. Betts et al.   PHARMACOLOGY & THERAPEUTICS

The Airway Epithelium is Central to the Pathogenesis of Asthma

(2008) Stephen T. Holgate   ALLERGOLOGY INTERNATIONAL