Membrane Progesterone Receptors (mPRs, PAQRs): Review of Structural and Signaling Characteristics

Establishment of a steroid binding assay for membrane progesterone receptor alpha (PAQR7) by using graphene quantum dots (GQDs)

(2022) Md. Maisum Sarwar Jyoti et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular modeling, mutational analysis and steroid specificity of the ligand binding pocket of mPRα (PAQR7): Shared ligand binding with AdipoR1 and its structural basis

(2022) Jan Kelder et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Involvement of sarco/endoplasmic reticulum Ca2+ _ATPase (SERCA) in mPRα (PAQR7)- mediated progesterone induction of vascular smooth muscle relaxation

(2021) Yefei Pang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Correction: Membrane progesterone receptor induces meiosis in Xenopus oocytes through endocytosis into signaling endosomes and interaction with APPL1 and Akt2

(2021) Nancy Nader et al.   PLOS BIOLOGY

Rapamycin Antagonizes BCRP-Mediated Drug Resistance Through the PI3K/Akt/mTOR Signaling Pathway in mPRα-Positive Breast Cancer

(2021) Jing Zhang et al.   Frontiers in Oncology

Recent progress in mass spectrometry-based strategies for elucidating protein–protein interactions

(2021) Teck Yew Low et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

PAQR7: An intermediary mediating nongenomic progesterone action in female reproductive tissue

(2021) Yijie Wang et al.   Reproductive Biology

Cytotoxic Effects of the Selective Ligands of Membrane Progesterone Receptors in Human Pancreatic Adenocarcinoma Cells BxPC3

(2021) Alexey I. Goncharov et al.   BIOCHEMISTRY-MOSCOW

What Do We Know about Classical and Non-Classical Progesterone Receptors in the Human Female Reproductive Tract? A Review

(2021) Yassmin Medina-Laver et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Progesterone/Org inhibits lung adenocarcinoma cell growth via membrane progesterone receptor alpha

(2020) Jian Xiao et al.   Thoracic Cancer

Anti-apoptotic Actions of Allopregnanolone and Ganaxolone Mediated Through Membrane Progesterone Receptors (PAQRs) in Neuronal Cells

(2020) Peter Thomas et al.   Frontiers in Endocrinology

Classical and Non-Classical Progesterone Signaling in Breast Cancers

(2020) Diego A. Pedroza et al.   Cancers

Bioluminescence Resonance Energy Transfer as a Method to Study Protein-Protein Interactions: Application to G Protein Coupled Receptor Biology

(2019) Chayma El Khamlichi et al.   MOLECULES

Genomic sequence analyses of classical and non-classical lamprey progesterone receptor genes and the inference of homologous gene evolution in metazoans

(2019) Jianfeng Ren et al.   BMC EVOLUTIONARY BIOLOGY

Metabotropic, but not allosteric, effects of neurosteroids on GABAergic inhibition depend on the phosphorylation of GABAA receptors

(2019) Manasa L. Parakala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Progesterone Receptors (mPRs/PAQRs) Differently Regulate Migration, Proliferation, and Differentiation in Rat Schwann Cells

(2019) Luca F. Castelnovo et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

mPRα mediates P4/Org OD02‐0 to improve the sensitivity of lung adenocarcinoma to EGFR‐TKIs via the EGFR‐SRC‐ERK1/2 pathway

(2019) Xiaoxiao Lu et al.   MOLECULAR CARCINOGENESIS

Roles of progesterone receptor membrane component 1 and membrane progestin receptor alpha in regulation of zebrafish oocyte maturation

(2018) Joseph Aizen et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

The VLDL receptor regulates membrane progesterone receptor trafficking and non-genomic signaling

(2018) Nancy Nader et al.   JOURNAL OF CELL SCIENCE

Function and structural regulation of the carbon monoxide (CO)-responsive membrane protein PGRMC1

(2018) Yasuaki Kabe et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Activation of membrane progesterone receptor-alpha increases proliferation, migration, and invasion of human glioblastoma cells

(2018) Juan Carlos González-Orozco et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Progesterone induces relaxation of human umbilical cord vascular smooth muscle cells through mPRα (PAQR7)

(2018) Yefei Pang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Insulin Receptor Plasma Membrane Levels Increased by the Progesterone Receptor Membrane Component 1

(2018) Kaia K. Hampton et al.   MOLECULAR PHARMACOLOGY

Pgrmc1 Knockout Impairs Oocyte Maturation in Zebrafish

(2018) Xin-Jun Wu et al.   Frontiers in Endocrinology

Induction of sperm hypermotility through membrane progestin receptor alpha (mPRα): A teleost model of rapid, multifaceted, nongenomic progestin signaling

(2018) Wenxian Tan et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Thoughts on interactions between PGRMC1 and diverse attested and potential hydrophobic ligands

(2017) Michael A. Cahill et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Structural insights into adiponectin receptors suggest ceramidase activity

(2017) Ieva Vasiliauskaité-Brooks et al.   NATURE

Membrane progesterone receptor beta (mPRβ/Paqr8) promotes progesterone-dependent neurite outgrowth in PC12 neuronal cells via non-G protein-coupled receptor (GPCR) signaling

(2017) Mayu Kasubuchi et al.   Scientific Reports

Membrane Associated Progesterone Receptors: Promiscuous Proteins with Pleiotropic Functions – Focus on Interactions with Cytochromes P450

(2017) Chang S. Ryu et al.   Frontiers in Pharmacology

Rodent Models of Non-classical Progesterone Action Regulating Ovulation

(2017) Melinda A. Mittelman-Smith et al.   Frontiers in Endocrinology

Progestin-mediated activation of MAPK and AKT in nuclear progesterone receptor negative breast epithelial cells: The role of membrane progesterone receptors

(2016) Monica Salazar et al.   GENE

Membrane progesterone receptors in reproduction and cancer

(2016) Paulina Valadez-Cosmes et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Nuclear magnetic resonance (NMR) applied to membrane–protein complexes

(2016) Mohammed Kaplan et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance

(2016) Yasuaki Kabe et al.   Nature Communications

Progesterone increases nitric oxide synthesis in human vascular endothelial cells through activation of membrane progesterone receptor-α

(2015) Yefei Pang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Progestin and AdipoQ Receptor 7, Progesterone Membrane Receptor Component 1 (PGRMC1), and PGRMC2 and Their Role in Regulating Progesterone's Ability to Suppress Human Granulosa/Luteal Cells from Entering into the Cell Cycle1

(2015) Carolina Sueldo et al.   BIOLOGY OF REPRODUCTION

Involvement of epidermal growth factor receptors and mitogen-activated protein kinase in progestin-induction of sperm hypermotility in Atlantic croaker through membrane progestin receptor-alpha

(2015) Wenxian Tan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Activation of the Pi3k/Akt Pathway and Modulation of Phosphodiesterase Activity via Membrane Progestin Receptor-Alpha (mPRalpha) Regulate Progestin-Initiated Sperm Hypermotility in Atlantic Croaker1

(2014) Wenxian Tan et al.   BIOLOGY OF REPRODUCTION

Enhancement of Cell Surface Expression and Receptor Functions of Membrane Progestin Receptor α (mPRα) by Progesterone Receptor Membrane Component 1 (PGRMC1): Evidence for a Role of PGRMC1 as an Adaptor Protein for Steroid Receptors

(2014) Peter Thomas et al.   ENDOCRINOLOGY

Membrane progestin receptor alpha mediates progestin-induced sperm hypermotility and increased fertilization success in southern flounder (Paralichthys lethostigma)

(2014) Wenxian Tan et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Progesterone-induced activation of membrane-bound progesterone receptors in murine macrophage cells

(2014) Jing Lu et al.   JOURNAL OF ENDOCRINOLOGY

A computational analysis of non-genomic plasma membrane progestin binding proteins: Signaling through ion channel-linked cell surface receptors

(2013) Gene A. Morrill et al.   STEROIDS

Non-genomic progesterone signalling and its non-canonical receptor

(2012) Patricia Moussatche et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Characterization, Neurosteroid Binding and Brain Distribution of Human Membrane Progesterone Receptors δ and ϵ (mPRδ and mPRϵ) and mPRδ Involvement in Neurosteroid Inhibition of Apoptosis

(2012) Yefei Pang et al.   ENDOCRINOLOGY

Changes in placental progesterone receptors in term and preterm labour

(2012) E. Zachariades et al.   PLACENTA

Membrane Progesterone Receptors (mPRs) Mediate Progestin Induced Antimorbidity in Breast Cancer Cells and Are Expressed in Human Breast Tumors

(2012) Gwen E. Dressing et al.   Hormones & Cancer

Expression, Regulation, and Function of Progesterone Receptors in Bovine Cumulus Oocyte Complexes During In Vitro Maturation1

(2011) I.M. Aparicio et al.   BIOLOGY OF REPRODUCTION

Rapid steroid hormone actions initiated at the cell surface and the receptors that mediate them with an emphasis on recent progress in fish models

(2011) Peter Thomas   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Role of G protein-coupled estrogen receptor 1, GPER, in inhibition of oocyte maturation by endogenous estrogens in zebrafish

(2010) Yefei Pang et al.   DEVELOPMENTAL BIOLOGY

Progestin Signaling Through mPRα in Atlantic Croaker Granulosa/Theca Cell Cocultures and Its Involvement in Progestin Inhibition of Apoptosis

(2010) Gwen E. Dressing et al.   ENDOCRINOLOGY

Identification of 17,20β,21-trihydroxy-4-pregnen-3-one (20β-S) receptor binding and membrane progestin receptor alpha on southern flounder sperm (Paralichthys lethostigma) and their likely role in 20β-S stimulation of sperm hypermotility

(2010) Christopher Tubbs et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Pgrmc1 (Progesterone Receptor Membrane Component 1) Associates with Epidermal Growth Factor Receptor and Regulates Erlotinib Sensitivity

(2010) Ikhlas S. Ahmed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparison between steroid binding to membrane progesterone receptor α (mPRα) and to nuclear progesterone receptor: Correlation with physicochemical properties assessed by comparative molecular field analysis and identification of mPRα-specific agonists

(2010) Jan Kelder et al.   STEROIDS

Membrane progesterone receptor expression in mammalian tissues: A review of regulation and physiological implications

(2010) Gwen E. Dressing et al.   STEROIDS

Expression of Membrane Progesterone Receptors (mPR/PAQR) in Ovarian Cancer Cells: Implications for Progesterone-Induced Signaling Events

(2010) Nathan J. Charles et al.   Hormones & Cancer

Progesterone Receptor A (PRA) and PRB-Independent Effects of Progesterone on Gonadotropin-Releasing Hormone Release

(2009) Nicole Sleiter et al.   ENDOCRINOLOGY

Internalisation of membrane progesterone receptor-α after treatment with progesterone: Potential involvement of a clathrin-dependent pathway

(2009) Karteris   Molecular Medicine Reports

Progestin Signaling through an Olfactory G Protein and Membrane Progestin Receptor-α in Atlantic Croaker Sperm: Potential Role in Induction of Sperm Hypermotility

(2008) Christopher Tubbs et al.   ENDOCRINOLOGY

Characteristics of membrane progestin receptor alpha (mPRα) and progesterone membrane receptor component 1 (PGMRC1) and their roles in mediating rapid progestin actions

(2008) Peter Thomas   FRONTIERS IN NEUROENDOCRINOLOGY

Heterologous expression of human mPRα, mPRβ and mPRγ in yeast confirms their ability to function as membrane progesterone receptors

(2008) Jessica L. Smith et al.   STEROIDS

Progestin functions in vertebrate gametes mediated by membrane progestin receptors (mPRs): Identification of mPRα on human sperm and its association with sperm motility

(2008) P. Thomas et al.   STEROIDS

Progesterone receptor membrane component 1—Many tasks for a versatile protein

(2007) R LOSEL et al.   STEROIDS