Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the HumanACVR1R206HFibrodysplasia Ossificans Progressiva (FOP) Mutation

The Type I BMP Receptor ACVR1/ALK2 is Required for Chondrogenesis During Development

(2015) Diana Rigueur et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Mechanisms of retinoic acid signalling and its roles in organ and limb development

(2015) Thomas J. Cunningham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ACVR1 R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A

(2015) Sarah J. Hatsell et al.   Science Translational Medicine

ACVR1 p.Q207E causes classic fibrodysplasia ossificans progressiva and is functionally distinct from the engineered constitutively active ACVR1 p.Q207D variant

(2014) Julia Haupt et al.   HUMAN MOLECULAR GENETICS

Alk2 Regulates Early Chondrogenic Fate in Fibrodysplasia Ossificans Progressiva Heterotopic Endochondral Ossification

(2014) Andria L. Culbert et al.   STEM CELLS

Sox9 Directs Hypertrophic Maturation and Blocks Osteoblast Differentiation of Growth Plate Chondrocytes

(2012) Peter Dy et al.   DEVELOPMENTAL CELL

Fibrodysplasia ossificans progressiva: mechanisms and models of skeletal metamorphosis

(2012) F. S. Kaplan et al.   Disease Models & Mechanisms

AnAcvr1R206H knock-in mouse has fibrodysplasia ossificans progressiva

(2012) Salin A Chakkalakal et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-γ agonists

(2011) Kengo Shimono et al.   NATURE MEDICINE

Role of Altered Signal Transduction in Heterotopic Ossification and Fibrodysplasia Ossificans Progressiva

(2011) Eileen M. Shore et al.   Current Osteoporosis Reports

Endogenous Retinoids in Mammalian Growth Plate Cartilage

(2010) Julie A. Williams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inherited human diseases of heterotopic bone formation

(2010) Eileen M. Shore et al.   Nature Reviews Rheumatology

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse

(2009) Julie A. Williams et al.   DEVELOPMENTAL BIOLOGY

Heterotopic Ossification in High-Energy Wartime Extremity Injuries: Prevalence and Risk Factors

(2009) Jonathan Agner Forsberg et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Fibrodysplasia ossificans progressiva

(2008) Frederick S. Kaplan et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1

(2008) Frederick S. Kaplan et al.   HUMAN MUTATION