More than a Bubble: Extracellular Vesicle microRNAs in Head and Neck Squamous Cell Carcinoma

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

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Human umbilical vein endothelial cells-derived microRNA-203-containing extracellular vesicles alleviate non-small-cell lung cancer progression through modulating the DTL/p21 axis

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MicroRNA‐370‐3p shuttled by breast cancer cell‐derived extracellular vesicles induces fibroblast activation through the CYLD/Nf‐κB axis to promote breast cancer progression

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Small extracellular vesicles containing miR-192/215 mediate hypoxia-induced cancer-associated fibroblast development in head and neck squamous cell carcinoma

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Liquid Biopsies in Head and Neck Cancer: Current State and Future Challenges

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Distinct mRNAs in Cancer Extracellular Vesicles Activate Angiogenesis and Alter Transcriptome of Vascular Endothelial Cells

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Exosomal miR-130b-3p Promotes Progression and Tubular Formation Through Targeting PTEN in Oral Squamous Cell Carcinoma

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Plasma extracellular vesicle microRNA‐491‐5p as diagnostic and prognostic marker for head and neck squamous cell carcinoma

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Hepatoma Cell-Derived Extracellular Vesicles Promote Liver Cancer Metastasis by Inducing the Differentiation of Bone Marrow Stem Cells Through microRNA-181d-5p and the FAK/Src Pathway

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Assessment of MicroRNA (miR)-365 Effects on Oral Squamous Carcinoma Cell Line Phenotypes

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HPV+ HNSCC-Derived Exosomal miR-9 Induces Macrophage M1 Polarization and Increases Tumor Radiosensitivity

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CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer

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Exosomal miR-200c suppresses chemoresistance of docetaxel in tongue squamous cell carcinoma by suppressing TUBB3 and PPP2R1B

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Identification of extracellular vesicles-transported miRNAs in Erlotinib-resistant head and neck squamous cell carcinoma

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Sorting Mechanisms for MicroRNAs into Extracellular Vesicles and Their Associated Diseases

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Liquid biopsies: Potential and challenges

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The Emerging Role of Exosomes in Diagnosis, Prognosis, and Therapy in Head and Neck Cancer

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miR-365 (microRNA): Potential Biomarker in Oral Squamous Cell Carcinoma Exosomes and Extracellular Vesicles

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Cross validated serum small extracellular vesicle microRNAs for the detection of oropharyngeal squamous cell carcinoma

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Liquid biopsy in head and neck squamous cell carcinoma: circulating tumor cells, circulating tumor DNA, and exosomes

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GC-Derived EVs Enriched with MicroRNA-675-3p Contribute to the MAPK/PD-L1-Mediated Tumor Immune Escape by Targeting CXXC4

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Head and neck squamous cell carcinoma

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Exosomal miR-590-3p derived from cancer-associated fibroblasts confers radioresistance in colorectal cancer

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Exosome-transmitted miR-128-3p increase chemosensitivity of oxaliplatin-resistant colorectal cancer

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Loss of exosomal miR-3188 in cancer-associated fibroblasts contributes to HNC progression

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Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review

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Emerging Function and Clinical Values of Exosomal microRNAs in Cancer

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Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: Identification, Characterization and Clinical Implications

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Exosomal miRNA-106b from cancer-associated fibroblast promotes gemcitabine resistance in pancreatic cancer

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Exosomes derived from microRNA-101-3p-overexpressing human bone marrow mesenchymal stem cells suppress oral cancer cell proliferation, invasion, and migration

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Cancer‑associated fibroblast‑derived exosomal miR‑382‑5p promotes the migration and invasion of oral squamous cell carcinoma

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Delivery of mesenchymal stem cells-derived extracellular vesicles with enriched miR-185 inhibits progression of OPMD

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NAD-Biosynthetic and Consuming Enzymes as Central Players of Metabolic Regulation of Innate and Adaptive Immune Responses in Cancer

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Heterogeneity of the Head and Neck Squamous Cell Carcinoma Immune Landscape and Its Impact on Immunotherapy

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Diagnostic Tumor Markers in Head and Neck Squamous Cell Carcinoma (HNSCC) in the Clinical Setting

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Exosomes in Head and Neck Squamous Cell Carcinoma

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Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease

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Salivary exosomal miR-24-3p serves as a potential detective biomarker for oral squamous cell carcinoma screening

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Ovatodiolide Suppresses Oral Cancer Malignancy by Down-Regulating Exosomal Mir-21/STAT3/β-Catenin Cargo and Preventing Oncogenic Transformation of Normal Gingival Fibroblasts

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Salivary extracellular vesicle-associated miRNAs as potential biomarkers in oral squamous cell carcinoma

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Liquid Biopsy in Head and Neck Cancer: Promises and Challenges

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Head and neck squamous cell carcinoma: Genomics and emerging biomarkers for immunomodulatory cancer treatments

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Snail-overexpressing Cancer Cells Promote M2-Like Polarization of Tumor-Associated Macrophages by Delivering MiR-21-Abundant Exosomes

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Extracellular vesicle microRNA cargo is correlated with HPV-status in oropharyngeal carcinoma

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Cancer-associated fibroblasts contribute to oral cancer cells proliferation and metastasis via exosome-mediated paracrine miR-34a-5p

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Microenvironmental oxygen pressure orchestrates an anti- and pro-tumoral γδ T cell equilibrium via tumor-derived exosomes

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Concise Reviews: Cancer Stem Cell Targeted Therapies: Toward Clinical Success

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γδTDEs: An Efficient Delivery System for miR-138 with Anti-tumoral and Immunostimulatory Roles on Oral Squamous Cell Carcinoma

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miR-200c-3p spreads invasive capacity in human oral squamous cell carcinoma microenvironment

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Exosomes in Cancer Nanomedicine and Immunotherapy: Prospects and Challenges

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Comprehensive microRNA-sequencing of exosomes derived from head and neck carcinoma cells in vitro reveals common secretion profiles and potential utility as salivary biomarkers

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Evidence-Based Treatment Options in Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck

(2017) Athanassios Argiris et al.   Frontiers in Oncology

Extracellular vesicles for drug delivery

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Exosomes Derived from Hypoxic Oral Squamous Cell Carcinoma Cells Deliver miR-21 to Normoxic Cells to Elicit a Prometastatic Phenotype

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Low Cancer Stem Cell Marker Expression and Low Hypoxia Identify Good Prognosis Subgroups in HPV(-) HNSCC after Postoperative Radiochemotherapy: A Multicenter Study of the DKTK-ROG

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Poor prognosis in human papillomavirus-positive oropharyngeal squamous cell carcinomas that overexpress hypoxia inducible factor-1α

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Overcoming barriers to effective immunotherapy: MDSCs, TAMs, and Tregs as mediators of the immunosuppressive microenvironment in head and neck cancer

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Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1

(2016) Chi Lam Au Yeung et al.   Nature Communications

KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes

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Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction

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Exosomal microRNA miR-1246 induces cell motility and invasion through the regulation of DENND2D in oral squamous cell carcinoma

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Phase II trial of everolimus and erlotinib in patients with platinum-resistant recurrent and/or metastatic head and neck squamous cell carcinoma

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Increased radiosensitivity of HPV-positive head and neck cancers: Molecular basis and therapeutic perspectives

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Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas

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γδT Cells: First Line of Defense and Beyond

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Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis

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γδT17 Cells Promote the Accumulation and Expansion of Myeloid-Derived Suppressor Cells in Human Colorectal Cancer

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Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery

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Combined detection of serum exosomal miR-21 and HOTAIR as diagnostic and prognostic biomarkers for laryngeal squamous cell carcinoma

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Exosome-mediated transfer of miR-10b promotes cell invasion in breast cancer

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miRNA cargo within exosome-like vesicle transfer influences metastatic bone colonization

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Time to deliver

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Biological Basis for Increased Sensitivity to Radiation Therapy in HPV-Positive Head and Neck Cancers

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From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation

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Exosomes Derived from Hypoxic Leukemia Cells Enhance Tube Formation in Endothelial Cells

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Cisplatin and Radiotherapy With or Without Erlotinib in Locally Advanced Squamous Cell Carcinoma of the Head and Neck: A Randomized Phase II Trial

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CCR2-Dependent Recruitment of Macrophages by Tumor-Educated Mesenchymal Stromal Cells Promotes Tumor Development and Is Mimicked by TNFα

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Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

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Microenvironment and Radiation Therapy

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Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth

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Intercellular nanovesicle-mediated microRNA transfer: A mechanism of environmental modulation of hepatocellular cancer cell growth

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Human Papillomavirus and Rising Oropharyngeal Cancer Incidence in the United States

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Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

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