MicroRNA-34c-5p provokes isoprenaline-induced cardiac hypertrophy by modulating autophagy via targeting ATG4B

Adiponectin receptor 1 variants contribute to hypertrophic cardiomyopathy that can be reversed by rapamycin

(2021) Perundurai S. Dhandapany et al.   Science Advances

MiR-34a inhibitor protects mesenchymal stem cells from hyperglycaemic injury through the activation of the SIRT1/FoxO3a autophagy pathway

(2021) Fengyun Zhang et al.   Stem Cell Research & Therapy

Targeting the MicroRNA-490-3p-ATG4B-Autophagy Axis Relieves Myocardial Injury in Ischemia Reperfusion

(2020) Yufu Wu et al.   Journal of Cardiovascular Translational Research

Downregulation of LAPTM4B Contributes to the Impairment of the Autophagic Flux via Unopposed Activation of mTORC1 Signaling During Myocardial Ischemia/Reperfusion Injury

(2020) Shanshan Gu et al.   CIRCULATION RESEARCH

Chloroquine against malaria, cancers and viral diseases

(2020) Wenmin Zhou et al.   DRUG DISCOVERY TODAY

MicroRNA-214 contributes to Ang II-induced cardiac hypertrophy by targeting SIRT3 to provoke mitochondrial malfunction

(2020) Yan-qing Ding et al.   ACTA PHARMACOLOGICA SINICA

MiR-103 inhibiting cardiac hypertrophy through inactivation of myocardial cell autophagy via targeting TRPV3 channel in rat hearts

(2019) Hanping Qi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Tumor-educated platelet miR-34c-3p and miR-18a-5p as potential liquid biopsy biomarkers for nasopharyngeal carcinoma diagnosis

(2019) Hui Wang et al.   Cancer Management and Research

MiR-34c acts as a tumor suppressor in non-small cell lung cancer by inducing endoplasmic reticulum stress through targeting HMGB1

(2019) Li Tu et al.   OncoTargets and Therapy

The study of mechanism of miR-34c-5p targeting FLOT2 to regulate proliferation, migration and invasion of osteosarcoma cells

(2019) Yuqiang Wang et al.   Artificial Cells Nanomedicine and Biotechnology

Targeting autophagy-related protein kinases for potential therapeutic purpose

(2019) Honggang Xiang et al.   Acta Pharmaceutica Sinica B

The Role of Autophagy in the Heart

(2018) Sebastiano Sciarretta et al.   Annual Review of Physiology

Metazoan MicroRNAs

(2018) David P. Bartel   CELL

Beclin-1-Dependent Autophagy Protects the Heart During Sepsis

(2018) Yuxiao Sun et al.   CIRCULATION

New Insights Into the Role of mTOR Signaling in the Cardiovascular System

(2018) Sebastiano Sciarretta et al.   CIRCULATION RESEARCH

Transplanted Mesenchymal Stem Cells Reduce Autophagic Flux in Infarcted Hearts via the Exosomal Transfer of mir-125b

(2018) Changchen Xiao et al.   CIRCULATION RESEARCH

miR-34c-5p promotes eradication of acute myeloid leukemia stem cells by inducing senescence through selective RAB27B targeting to inhibit exosome shedding

(2018) Danyue Peng et al.   LEUKEMIA

JMJD3 inhibition protects against isoproterenol-induced cardiac hypertrophy by suppressing β-MHC expression

(2018) Zhen Guo et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mechanisms of physiological and pathological cardiac hypertrophy

(2018) Michinari Nakamura et al.   Nature Reviews Cardiology

Cardioprotective effects of autophagy: Eat your heart out, heart failure!

(2018) Gaetano Santulli   Science Translational Medicine

Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo

(2018) Yuanyuan Fu et al.   Autophagy

M 4 IDP, a zoledronic acid derivative, induces G1 arrest, apoptosis and autophagy in HCT116 colon carcinoma cells via blocking PI3K/Akt/mTOR pathway

(2017) Ying Peng et al.   LIFE SCIENCES

Activation of miR-34a impairs autophagic flux and promotes cochlear cell death via repressing ATG9A: implications for age-related hearing loss

(2017) Jiaqi Pang et al.   Cell Death & Disease

MicroRNA-100 Suppresses Chronic Vascular Inflammation by Stimulation of Endothelial Autophagy

(2017) Franziska Pankratz et al.   CIRCULATION RESEARCH

MicroRNAs in heart failure: from biomarker to target for therapy

(2016) Eline L. Vegter et al.   EUROPEAN JOURNAL OF HEART FAILURE

SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy

(2016) Jing Lu et al.   Translational Research

Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets

(2015) Yow Keat Tham et al.   ARCHIVES OF TOXICOLOGY

miR-199a impairs autophagy and induces cardiac hypertrophy through mTOR activation

(2015) Z Li et al.   CELL DEATH AND DIFFERENTIATION

miR-206 Mediates YAP-Induced Cardiac Hypertrophy and SurvivalNovelty and Significance

(2015) Yanfei Yang et al.   CIRCULATION RESEARCH

MicroRNA-34 Family and Its Role in Cardiovascular Disease

(2015) Na Li et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Effects of miRNA-455 on cardiac hypertrophy induced by pressure overload

(2015) CHUNTAO WU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Global microRNA profiles and signaling pathways in the development of cardiac hypertrophy

(2014) H.J. Feng et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers

(2014) K. M. Akat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The p53/miR-34 axis in development and disease

(2014) M. Rokavec et al.   Journal of Molecular Cell Biology

MicroRNA-22 Regulates Cardiac Hypertrophy and Remodeling in Response to Stress

(2013) Zhan-Peng Huang et al.   CIRCULATION RESEARCH

β-Arrestin1–Biased β 1 -Adrenergic Receptor Signaling Regulates MicroRNA Processing

(2013) Il-man Kim et al.   CIRCULATION RESEARCH

Plasma microRNAs serve as biomarkers of therapeutic efficacy and disease progression in hypertension-induced heart failure

(2013) Brent A. Dickinson et al.   EUROPEAN JOURNAL OF HEART FAILURE

miRNA expression in pediatric failing human heart

(2013) Brian L. Stauffer et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

MicroRNA-34a regulates cardiac ageing and function

(2013) Reinier A. Boon et al.   NATURE

Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2

(2013) Yasuhiro Maejima et al.   NATURE MEDICINE

MicroRNA Dysregulation in Diabetic Ischemic Heart Failure Patients

(2012) S. Greco et al.   DIABETES

Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function

(2012) B. C. Bernardo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C-Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival

(2012) F. J. Ramos et al.   Science Translational Medicine

The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy

(2012) Ahmet Ucar et al.   Nature Communications

PI3K(p110α) Protects Against Myocardial Infarction-Induced Heart Failure

(2010) Ruby C.Y. Lin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Kinetics Comparisons of Mammalian Atg4 Homologues Indicate Selective Preferences toward Diverse Atg8 Substrates

(2010) Min Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

The role of autophagy in the heart

(2008) K Nishida et al.   CELL DEATH AND DIFFERENTIATION

The impact of microRNAs on protein output

(2008) Daehyun Baek et al.   NATURE

Widespread changes in protein synthesis induced by microRNAs

(2008) Matthias Selbach et al.   NATURE

Cardiac Plasticity

(2008) Joseph A. Hill et al.   NEW ENGLAND JOURNAL OF MEDICINE