Adiponectin receptor 1 variants contribute to hypertrophic cardiomyopathy that can be reversed by rapamycin

New Insights Into the Role of mTOR Signaling in the Cardiovascular System

(2018) Sebastiano Sciarretta et al.   CIRCULATION RESEARCH

OUP accepted manuscript

(2018)   EUROPEAN HEART JOURNAL

p38 MAP kinases in the heart

(2016) Tomohiro Yokota et al.   GENE

Clinical and Mechanistic Insights Into the Genetics of Cardiomyopathy

(2016) Michael A. Burke et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis

(2016) J. Travis Hinson et al.   Cell Reports

The Genetic Landscape of Cardiomyopathy and Its Role in Heart Failure

(2015) Elizabeth M. McNally et al.   Cell Metabolism

Investigation of Pathogenic Genes in Chinese sporadic Hypertrophic Cardiomyopathy Patients by Whole Exome Sequencing

(2015) Jing Xu et al.   Scientific Reports

Mammalian Target of Rapamycin Signaling in Cardiac Physiology and Disease

(2014) Sebastiano Sciarretta et al.   CIRCULATION RESEARCH

Mutation in the γ2-Subunit of AMP-Activated Protein Kinase Stimulates Cardiomyocyte Proliferation and Hypertrophy Independent of Glycogen Storage

(2014) Maengjo Kim et al.   CIRCULATION RESEARCH

Adiponectin receptor 1 overexpression reduces lipid accumulation and hypertrophy in the heart of diet-induced obese mice – possible involvement of oxidative stress and autophagy

(2014) I-Pin Chou et al.   ENDOCRINE RESEARCH

RAF1 mutations in childhood-onset dilated cardiomyopathy

(2014) Perundurai S Dhandapany et al.   NATURE GENETICS

Mechanistic Target of Rapamycin Complex 2 Protects the Heart From Ischemic Damage

(2013) Mirko Völkers et al.   CIRCULATION

Myocardial Loss of IRS1 and IRS2 Causes Heart Failure and Is Controlled by p38  MAPK During Insulin Resistance

(2013) Y. Qi et al.   DIABETES

Temsirolimus Activates Autophagy and Ameliorates Cardiomyopathy Caused by Lamin A/C Gene Mutation

(2012) J. C. Choi et al.   Science Translational Medicine

mTOR signaling in disease

(2011) Eva Dazert et al.   CURRENT OPINION IN CELL BIOLOGY

Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome–associated PTPN11 mutation

(2011) Talita M. Marin et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of disease: hypertrophic cardiomyopathy

(2011) Norbert Frey et al.   Nature Reviews Cardiology

Extracellular Signal-Regulated Kinases 1 and 2 Regulate the Balance Between Eccentric and Concentric Cardiac Growth

(2010) Izhak Kehat et al.   CIRCULATION RESEARCH

The p38 mitogen-activated protein kinase pathway—A potential target for intervention in infarction, hypertrophy, and heart failure

(2010) Michael S. Marber et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1

(2010) Masato Iwabu et al.   NATURE

Beneficial Effects of Mammalian Target of Rapamycin Inhibition on Left Ventricular Remodeling After Myocardial Infarction

(2009) Sebastian J. Buss et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A common MYBPC3 (cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia

(2009) Perundurai S Dhandapany et al.   NATURE GENETICS

The Adiponectin Receptors AdipoR1 and AdipoR2 Activate ERK1/2 through a Src/Ras-Dependent Pathway and Stimulate Cell Growth†

(2008) Mi-Hye Lee et al.   BIOCHEMISTRY

Transcriptional control of mitochondrial biogenesis: the central role of PGC-1 

(2008) R. Ventura-Clapier et al.   CARDIOVASCULAR RESEARCH