Preclinical studies of the triazolo[1,5-a]pyrimidine derivative WS-716 as a highly potent, specific and orally active P-glycoprotein (P-gp) inhibitor

Polyoxypregnanes as safe, potent and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo

(2021) Xu Wu et al.   Acta Pharmaceutica Sinica B

Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors

(2021) Shuo Yuan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of the Triazolo[1,5-a]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance

(2021) Shuai Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Medicinal chemistry strategies to discover P-glycoprotein inhibitors: An update

(2020) Jinyun Dong et al.   DRUG RESISTANCE UPDATES

Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5-a]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators

(2020) Shuai Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nobiletin and its derivatives overcome multidrug resistance (MDR) in cancer: Total synthesis and discovery of potent MDR reversal agents

(2019) Senling Feng et al.   Acta Pharmaceutica Sinica B

Interferon regulatory factor-1 reverses chemoresistance by downregulating the expression of P-glycoprotein in gastric cancer

(2019) Jingsheng Yuan et al.   CANCER LETTERS

Combinatory antitumor therapy by cascade targeting of a single drug

(2019) Aiyun Liu et al.   Acta Pharmaceutica Sinica B

A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell–Intrinsic Transcriptional MSI Traits

(2019) Simona Corso et al.   CANCER RESEARCH

The use of ultrasound to increase the uptake and cytotoxicity of dual taxane and P-glycoprotein inhibitor loaded, solid core nanoparticles in drug resistant cells

(2019) John Jackson et al.   ULTRASONICS

Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1

(2018) Amer Alam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Steroidal dimer by001 inhibits proliferation and migration of esophageal cancer cells via multiple mechanisms

(2018) Sai-Qi Wang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Olmutinib (BI1482694/HM61713), a Novel Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, Reverses ABCG2-Mediated Multidrug Resistance in Cancer Cells

(2018) Wei Zhang et al.   Frontiers in Pharmacology

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

(2017) Tsukasa Shibue et al.   Nature Reviews Clinical Oncology

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade

(2016) Zhaolin Chen et al.   CANCER LETTERS

Geridonin and paclitaxel act synergistically to inhibit the proliferation of gastric cancer cells through ROS-mediated regulation of the PTEN/PI3K/Akt pathway

(2016) Sai-Qi Wang et al.   Oncotarget

DCTPP1 attenuates the sensitivity of human gastric cancer cells to 5-fluorouracil by up-regulating MDR1 expression epigenetically

(2016) Li-liang Xia et al.   Oncotarget

The modulation of ABC transporter-mediated multidrug resistance in cancer: A review of the past decade

(2015) Rishil J. Kathawala et al.   DRUG RESISTANCE UPDATES

Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy

(2015) Renata Silva et al.   PHARMACOLOGY & THERAPEUTICS

Semi-synthetic ocotillol analogues as selective ABCB1-mediated drug resistance reversal agents

(2015) Yun-Kai Zhang et al.   Oncotarget

Dasatinib reverses the multidrug resistance of breast cancer MCF-7 cells to doxorubicin by downregulating P-gp expression via inhibiting the activation of ERK signaling pathway

(2014) Ting Chen et al.   CANCER BIOLOGY & THERAPY

P-glycoprotein Inhibition as a Therapeutic Approach for Overcoming Multidrug Resistance in Cancer: Current Status and Future Perspectives

(2013) Ziyad Binkhathlan et al.   CURRENT CANCER DRUG TARGETS

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Recent Advances in the Development of P-gp Inhibitors

(2012) Christiane Baumert et al.   Anti-Cancer Agents in Medicinal Chemistry

Sildenafil Reverses ABCB1- and ABCG2-Mediated Chemotherapeutic Drug Resistance

(2011) Z. Shi et al.   CANCER RESEARCH

Verapamil Results in Increased Blood Levels of Oncolytic Adenovirus in Treatment of Patients With Advanced Cancer

(2011) Anniina Koski et al.   MOLECULAR THERAPY

Apatinib (YN968D1) Reverses Multidrug Resistance by Inhibiting the Efflux Function of Multiple ATP-Binding Cassette Transporters

(2010) Y.-j. Mi et al.   CANCER RESEARCH

A Pharmacodynamic Study of Docetaxel in Combination with the P-glycoprotein Antagonist Tariquidar (XR9576) in Patients with Lung, Ovarian, and Cervical Cancer

(2010) R. J. Kelly et al.   CLINICAL CANCER RESEARCH

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Verapamil Toxicity Dysregulates the Phosphatidylinositol 3-Kinase Pathway

(2008) Laura K. Bechtel et al.   ACADEMIC EMERGENCY MEDICINE

Lapatinib (Tykerb, GW572016) Reverses Multidrug Resistance in Cancer Cells by Inhibiting the Activity of ATP-Binding Cassette Subfamily B Member 1 and G Member 2

(2008) C.-l. Dai et al.   CANCER RESEARCH