Polyoxypregnanes as safe, potent and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo

Xiaoaiping injection enhances paclitaxel efficacy in ovarian cancer via pregnane X receptor and its downstream molecules

(2020) Xiang-Qi Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Tenacigenin B ester derivatives from Marsdenia tenacissima actively inhibited CYP3A4 and enhanced in vivo antitumor activity of paclitaxel

(2019) Bin Xie et al.   JOURNAL OF ETHNOPHARMACOLOGY

Oral and injectable Marsdenia tenacissima extract (MTE) as adjuvant therapy to chemotherapy for gastric cancer: a systematic review

(2019) Xu Zhou et al.   BMC Complementary and Alternative Medicine

The positive inotropic agent DPI-201106 selectively reverses ABCB1-mediated multidrug resistance in cancer cell lines

(2018) Sung-Han Hsiao et al.   CANCER LETTERS

Reversal of multidrug resistance by Marsdenia tenacissima and its main active ingredients polyoxypregnanes

(2017) Kenneth K.W. To et al.   JOURNAL OF ETHNOPHARMACOLOGY

Adduct ion-targeted qualitative and quantitative analysis of polyoxypregnanes by ultra-high pressure liquid chromatography coupled with triple quadrupole mass spectrometry

(2017) Xu Wu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

The long persistence of pyrrolizidine alkaloid-derived DNA adducts in vivo: kinetic study following single and multiple exposures in male ICR mice

(2016) Lin Zhu et al.   ARCHIVES OF TOXICOLOGY

Interactions of human P-glycoprotein transport substrates and inhibitors at the drug binding domain: Functional and molecular docking analyses

(2016) Onat Kadioglu et al.   BIOCHEMICAL PHARMACOLOGY

Polyoxypregnane steroids with an open-chain sugar moiety from Marsdenia tenacissima and their chemoresistance reversal activity

(2016) Sheng Yao et al.   PHYTOCHEMISTRY

Pharmacokinetic and pharmacodynamic study of tariquidar (XR9576), a P-glycoprotein inhibitor, in combination with doxorubicin, vinorelbine, or docetaxel in children and adolescents with refractory solid tumors

(2015) Elizabeth Fox et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Reversal of P-gp and BCRP-mediated MDR by tariquidar derivatives

(2015) Xu-Qin Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Marsdenia tenacssimaextract and its functional components inhibits proliferation and induces apoptosis of human Burkitt leukemia/lymphoma cellsin vitroandin vivo

(2015) Dong Li et al.   LEUKEMIA & LYMPHOMA

Polyoxypregnane Steroids from the Stems of Marsdenia tenacissima

(2014) Sheng Yao et al.   JOURNAL OF NATURAL PRODUCTS

Total Aglycones from Marsdenia tenacissima Increases Antitumor Efficacy of Paclitaxel in Nude Mice

(2014) Rui-Jing Zhu et al.   MOLECULES

P-glycoprotein Inhibition as a Therapeutic Approach for Overcoming Multidrug Resistance in Cancer: Current Status and Future Perspectives

(2013) Ziyad Binkhathlan et al.   CURRENT CANCER DRUG TARGETS

The ATPase Activity of the P-glycoprotein Drug Pump Is Highly Activated When the N-terminal and Central Regions of the Nucleotide-binding Domains Are Linked Closely Together

(2012) Tip W. Loo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of oral curcumin on the pharmacokinetics of intravenous and oral etoposide in rats: possible role of intestinal CYP3A and P-gp inhibition by curcumin

(2011) Chong-Ki Lee et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

P-glycoprotein Inhibition: The Past, the Present and the Future

(2011) Richard A.J. Darby et al.   CURRENT DRUG METABOLISM

Marsdenia tenacissima extract restored gefitinib sensitivity in resistant non-small cell lung cancer cells

(2011) Shu-Yan Han et al.   LUNG CANCER

The “Specific” P-Glycoprotein Inhibitor Tariquidar Is Also a Substrate and an Inhibitor for Breast Cancer Resistance Protein (BCRP/ABCG2)

(2010) Pavitra Kannan et al.   ACS Chemical Neuroscience

In vitro study of P-glycoprotein induction as an antidotal pathway to prevent cytotoxicity in Caco-2 cells

(2010) Renata Silva et al.   ARCHIVES OF TOXICOLOGY

Characterization of Metabolism andin VitroPermeability Study of Notoginsenoside R1 from Radix Notoginseng

(2010) Jian-Qing Ruan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

PSC833, cyclosporine analogue, downregulates MDR1 expression by activating JNK/c-Jun/AP-1 and suppressing NF-κB

(2009) H. Bark et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Development of inhibitors of ATP-binding cassette drug transporters – present status and challenges

(2008) Suneet Shukla et al.   Expert Opinion on Drug Metabolism & Toxicology

Tenacigenin B Derivatives Reverse P-Glycoprotein-Mediated Multidrug Resistance inHepG2/Dox Cells

(2008) Ying-Jie Hu et al.   JOURNAL OF NATURAL PRODUCTS