Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging

Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction

(2020) Ana Andres-Hernando et al.   Cell Metabolism

High-fructose corn syrup enhances intestinal tumor growth in mice

(2019) Marcus D. Goncalves et al.   SCIENCE

Metabolic Imaging of the Human Brain with Hyperpolarized13C Pyruvate Demonstrates13C Lactate Production in Brain Tumor Patients

(2018) Vesselin Z. Miloushev et al.   CANCER RESEARCH

Late-stage deuteration of 13C-enriched substrates for T1 prolongation in hyperpolarized 13C MRI

(2018) Céline Taglang et al.   CHEMICAL COMMUNICATIONS

A non-synthetic approach to extending the lifetime of hyperpolarized molecules using D2O solvation

(2018) Andrew Cho et al.   JOURNAL OF MAGNETIC RESONANCE

Chromatin states define tumour-specific T cell dysfunction and reprogramming

(2017) Mary Philip et al.   NATURE

Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing

(2017) Miguel Crespo et al.   NATURE MEDICINE

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

(2017) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

DNAJB1–PRKACAfusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma

(2017) Edward R. Kastenhuber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced Fructose Utilization Mediated by SLC2A5 Is a Unique Metabolic Feature of Acute Myeloid Leukemia with Therapeutic Potential

(2016) Wen-Lian Chen et al.   CANCER CELL

Hyperpolarized 13 C Metabolic MRI of the Human HeartNovelty and Significance

(2016) Charles H. Cunningham et al.   CIRCULATION RESEARCH

Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis

(2016) Andrea Schietinger et al.   IMMUNITY

A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation

(2016) Xinjian Li et al.   NATURE CELL BIOLOGY

Novel Approaches to Imaging Tumor Metabolism

(2015) Sui-Seng Tee et al.   CANCER JOURNAL

Orchestrating liver development

(2015) M. Gordillo et al.   DEVELOPMENT

Different approaches for interpretation and reporting of immunohistochemistry analysis results in the bone tissue – a review

(2014) Nickolay Fedchenko et al.   Diagnostic Pathology

A quick look at biochemistry: Carbohydrate metabolism

(2013) Monireh Dashty   CLINICAL BIOCHEMISTRY

F stands for fructose and fat

(2013) Costas A. Lyssiotis et al.   NATURE

Fructose in perspective

(2013) Richard D Feinman et al.   Nutrition & Metabolism

Glycolytic strategy as a tradeoff between energy yield and protein cost

(2013) A. Flamholz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1-13C]Pyruvate

(2013) S. J. Nelson et al.   Science Translational Medicine

Stereo- and Regioselective Direct Multi-Deuterium-Labeling Methods for Sugars

(2012) Yoshinari Sawama et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fructose metabolism in humans – what isotopic tracer studies tell us

(2012) Sam Z Sun et al.   Nutrition & Metabolism

Uric Acid Stimulates Fructokinase and Accelerates Fructose Metabolism in the Development of Fatty Liver

(2012) Miguel A. Lanaspa et al.   PLoS One

Rescued Tolerant CD8 T Cells Are Preprogrammed to Reestablish the Tolerant State

(2012) A. Schietinger et al.   SCIENCE

Radiopharmacological evaluation of 6-deoxy-6-[18F]fluoro-d-fructose as a radiotracer for PET imaging of GLUT5 in breast cancer

(2011) Melinda Wuest et al.   NUCLEAR MEDICINE AND BIOLOGY

Tumor agonist peptides break tolerance and elicit effective CTL responses in an inducible mouse model of hepatocellular carcinoma

(2009) Simone Stahl et al.   IMMUNOLOGY LETTERS

Ketohexokinase: Expression and Localization of the Principal Fructose-metabolizing Enzyme

(2009) Christine P. Diggle et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Hyperpolarized [2-13C]-Fructose: A Hemiketal DNP Substrate for In Vivo Metabolic Imaging

(2009) Kayvan R. Keshari et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regulation of the fructose transporter GLUT5 in health and disease

(2008) Veronique Douard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Tissue expression of ketohexokinase in cats

(2008) Nora Springer et al.   RESEARCH IN VETERINARY SCIENCE