Deubiquitinase CYLD acts as a negative regulator of dopamine neuron survival in Parkinson’s disease

Deficiency of the CYLD Impairs Fear Memory of Mice and Disrupts Neuronal Activity and Synaptic Transmission in the Basolateral Amygdala

(2021) Hui-dong Li et al.   Frontiers in Cellular Neuroscience

USP10 inhibits the dopamine-induced reactive oxygen species–dependent apoptosis of neuronal cells by stimulating the antioxidant Nrf2 activity

(2021) Junya Sango et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency

(2020) Sheila K. Pirooznia et al.   Molecular Neurodegeneration

CYLD is a causative gene for frontotemporal dementia – amyotrophic lateral sclerosis

(2020) Carol Dobson-Stone et al.   BRAIN

PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson’s disease

(2020) Preston Ge et al.   Molecular Neurodegeneration

Microglial activation in the dorsal striatum participates in anxiety-like behavior in Cyld knockout mice

(2020) Yuan-Yuan Han et al.   BRAIN BEHAVIOR AND IMMUNITY

Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PARKIN-Deficient Human Dopamine Neurons

(2020) Manoj Kumar et al.   Stem Cell Reports

Spatially Stable Mitochondrial Compartments Fuel Local Translation during Plasticity

(2019) Vidhya Rangaraju et al.   CELL

Tumor suppressor protein CYLD regulates morphogenesis of dendrites and spines

(2019) Jun Li et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson’s disease

(2019) Saurav Brahmachari et al.   BRAIN

The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD

(2019) Atsushi Uematsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Shank3 regulates striatal synaptic abundance of Cyld, a deubiquitinase specific for Lys63‐linked polyubiquitin chains

(2019) Chunmei Jin et al.   JOURNAL OF NEUROCHEMISTRY

Catalytic domain mutation in CYLD inactivates its enzyme function by structural perturbation and induces cell migration and proliferation

(2018) Tanu Johari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cylindromatosis mediates neuronal cell death in vitro and in vivo

(2018) Goutham K. Ganjam et al.   CELL DEATH AND DIFFERENTIATION

USP14 inhibition corrects an in vivo model of impaired mitophagy

(2018) Joy Chakraborty et al.   EMBO Molecular Medicine

Proteasome-independent polyubiquitin linkage regulates synapse scaffolding, efficacy, and plasticity

(2017) Qi Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

(2017) Yunjong Lee et al.   Cell Reports

PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson’s Disease Pathobiology?

(2017) Dominika Truban et al.   Journal of Parkinsons Disease

Linear ubiquitination by LUBEL has a role in Drosophila heat stress response

(2016) Tomoko Asaoka et al.   EMBO REPORTS

LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity

(2016) Senthilkumar S. Karuppagounder et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Detrimental effects of oxidative losses in parkin activity in a model of sporadic Parkinson's disease are attenuated by restoration of PGC1alpha

(2016) Almas Siddiqui et al.   NEUROBIOLOGY OF DISEASE

Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease

(2016) Zoi Alexopoulou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathological  -synuclein transmission initiated by binding lymphocyte-activation gene 3

(2016) X. Mao et al.   SCIENCE

Understanding the susceptibility of dopamine neurons to mitochondrial stressors in Parkinson's disease

(2015) Dominik Haddad et al.   FEBS LETTERS

Mitochondrial Quality Control via the PGC1 -TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin

(2015) A. Siddiqui et al.   JOURNAL OF NEUROSCIENCE

Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration

(2015) Daniel A. Stevens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IKK regulates the deubiquitinase CYLD at the postsynaptic density

(2014) Soe Thein et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy

(2014) Tom Cornelissen et al.   HUMAN MOLECULAR GENETICS

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation

(2014) Yunfan Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkin and PINK1: much more than mitophagy

(2014) Leslie A. Scarffe et al.   TRENDS IN NEUROSCIENCES

SNAP-Tag Technology: A Powerful Tool for Site Specific Conjugation of Therapeutic and Imaging Agents

(2013) Ahmad Hussain et al.   CURRENT PHARMACEUTICAL DESIGN

CYLD, a deubiquitinase specific for lysine63-linked polyubiquitins, accumulates at the postsynaptic density in an activity-dependent manner

(2012) Ayse Dosemeci et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ih Current Is Necessary to Maintain Normal Dopamine Fluctuations and Sleep Consolidation in Drosophila

(2012) Alicia Gonzalo-Gomez et al.   PLoS One

A Targeted In Vivo RNAi Screen Reveals Deubiquitinases as New Regulators of Notch Signaling

(2012) Junzheng Zhang et al.   G3-Genes Genomes Genetics

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

(2011) Joo-Ho Shin et al.   CELL

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

(2011) Sonja Kriks et al.   NATURE

Caspase 8 inhibits programmed necrosis by processing CYLD

(2011) Marie Anne O’Donnell et al.   NATURE CELL BIOLOGY

 -Synuclein fate is determined by USP9X-regulated monoubiquitination

(2011) R. Rott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Machado–Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability

(2010) Thomas M. Durcan et al.   HUMAN MOLECULAR GENETICS

CYLD: a tumor suppressor deubiquitinase regulating NF-κB activation and diverse biological processes

(2009) S-C Sun   CELL DEATH AND DIFFERENTIATION

SUnSET, a nonradioactive method to monitor protein synthesis

(2009) Enrico K Schmidt et al.   NATURE METHODS

Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway

(2008) Junichi Hitomi et al.   CELL