Article
Chemistry, Physical
Rajaram Rajamohan, Mika Sillanpaa, Angaiah Subramania
Summary: Nanofibrous mats and cyclodextrins are essential components in drug releasing systems, with cyclodextrins playing a key role in enhancing drug release profile by forming inclusion complexes. This study focused on analyzing the drug release profile of benzocaine using electrospun PVdF nanofibrous mats, with and without beta-cyclodextrin, demonstrating enhanced drug release ability with the presence of beta-CD due to increased solubility of benzocaine.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Medicine, Research & Experimental
Asli Celebioglu, Nancy Wang, Mehmet E. Kilic, Engin Durgun, Tamer Uyar
Summary: The study demonstrates the use of cyclodextrins to improve the solubility and bioavailability of prednisolone, creating nanofibrous webs that release the drug faster, potentially offering an alternative to orally disintegrating tablet formulations.
MOLECULAR PHARMACEUTICS
(2021)
Article
Chemistry, Physical
Jaya R. Lakkakula, Rui Werner Macedo Krause, Deepika Divakaran, Sagar Barage, Rohit Srivastava
Summary: The circulation time and solubility of 5-Fluorouracil have been prolonged and increased by complexing it with cyclodextrin and conjugating it onto gold nanoparticles to form 5Fu ICAu. The 5Fu-ICAu system showed higher cell inhibition rate on breast cancer cell lines due to the enhanced EPR effect allowing selective accumulation of nanoparticles at tumor sites.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Pharmacology & Pharmacy
O. Sreekanth Reddy, M. C. S. Subha, T. Jithendra, C. Madhavi, K. Chowdoji Rao
Summary: The aim of this study was to fabricate dual cross linked sodium alginate/montmorillonite microbeads as a potential drug carrier for extended release of curcumin. Characterization of the microbeads was done using FTIR, DSC, TGA, X-RD, and SEM. The swelling and in vitro release studies of the microbeads were influenced by the pH of test media, indicating their potential for intestinal drug delivery.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2021)
Article
Chemistry, Physical
Swapna Poudwal, Ambikanandan Misra, Pravin Shende
Summary: The present research aimed to increase the oral bioavailability of insulin and enhance patient compliance by formulating a PEI-surface-modified inclusion complex of human insulin with 2-hydroxypropyl-B-cyclodextrin and loading it into SNEDDS. The combination of inclusion complex and SNEDDS showed the potential for oral administration of insulin.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Nanoscience & Nanotechnology
Mariam Khachani, Samuel Stealey, Ether Dharmesh, Mohammad S. Kader, Steven W. Buckner, Paul A. Jelliss, Silviya Petrova Zustiak
Summary: Hydrogels have tunability and biocompatibility, but are not good at delivering small molecules due to high burst release and rapid diffusion. Nanosilicate clays can improve this issue by slowing down the release kinetics. In this study, the adsorption of small molecules onto three nanoclays (Laponite, montmorillonite, and halloysite) was characterized, and the addition of nanoclays significantly slowed down the release of small molecules from hydrogels.
ACS APPLIED NANO MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Mohammadjavad Ahmadi, Mehrab Pourmadadi, Sohrab Ali Ghorbanian, Fatemeh Yazdian, Hamid Rashedi
Summary: Recent studies have focused on investigating the harmful side effects of chemotherapeutic agents, with Fe2O3 nanoparticles being explored as potential drug carriers due to their porosity. A nanocomposite of Fe2O3/chitosan/montmorillonite was developed to encapsulate quercetin nanoparticles with less side effects. The designed Fe2O3-CS-MMT@QC showed high drug encapsulation efficiency and controlled release, demonstrating potential for drug delivery to cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Fengrong Gong, Lihui Jiang, Yanni Gao, Juan Xu, Ting Wang
Summary: To enhance the solubility of ethinylestradiol (EE) in water, researchers prepared diethylenetriamine-beta-cyclodextrin/ethinylestradiol (DETA-beta-CD/EE) complex and designed core-shell composite hydrogel capsules with aldocellulose and hydroxyethyl cellulose as the core and sodium alginate as the shell. The prepared hydrogel capsules exhibited controlled and sustained release of soluble DETA-beta-CD/EE, pH-responsiveness to intestinal fluid, and non-toxicity to normal human cells.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Chemistry, Medicinal
Sameer Joshi, Rajnish Sahu, Vida A. Dennis, Shree R. Singh
Summary: The research combines alginate and montmorillonite to produce a soft non-gelatin modified-release capsule, which was critically analyzed for appearance, functionality, and durability. These capsules offer unique advantages in terms of appearance, functionality, and durability.
Article
Chemistry, Applied
Hsuan-Jung Huang, Shih-Yu Huang, Tzu-Hao Wang, Tzu-Yun Lin, Nan-Ching Huang, Orion Shih, U-Ser Jeng, Che-Yi Chu, Wen-Hsuan Chiang
Summary: In this study, PEG-CS/MMT nanosheets were synthesized to address the issue of flocculation of montmorillonite nanoclays under physiological conditions, thus making them suitable for drug delivery applications.
CARBOHYDRATE POLYMERS
(2023)
Article
Pharmacology & Pharmacy
Dayanne Tomaz Casimiro Silva, Igor Eduardo Silva Arruda, Jose Izak Ribeiro de Araujo, Denise de Brito Franca, Bolivar Ponciano Goulart de Lima Damasceno, Fatima de Cassia Evangelista de Oliveira, Claudia Pessoa, Monica Felts de La Roca Soares, Maria Gardennia Fonseca, Jose Lamartine Soares-Sobrinho
Summary: In this study, a controlled-release system of tamoxifen citrate (TMX) loaded in pharmaceutical montmorillonite (VHS) was evaluated for its cytotoxic activity. The results showed successful intercalation of TMX in VHS and cytotoxic activity at certain concentrations without causing damage to normal cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Funda Altunkaynak, Mujgan Okur, Nurdan Saracoglu
Summary: Controlled drug delivery studies are popular in the pharmaceutical field, and polymeric composites prepared with clay have great potential importance in drug release studies.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Alireza Ghannad Sabzevari, Hossein Sabahi, Mohsen Nikbakht, Steven J. P. McInnes
Summary: An oral controlled-release formulation of epigallocatechin-3-gallate (EGCG) was developed by intercalating EGCG into mucoadhesive montmorillonite (Mt) nanolayers. The EGCG-loaded Mt showed sustained release of EGCG in a pH-dependent manner, making it a potential nanocarrier for oral administration of EGCG. The study provided valuable insights into the release mechanism and application of EGCG in oral drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ying Qu, Xiao Sun, Long Ma, Chunyan Li, Zixuan Xu, Wenqing Ma, Yingying Zhou, Zhongxi Zhao, Dedong Ma
Summary: By embedding DSF in HP-β-CD to prepare an inclusion complex with enhanced solubility and anti-GBM activity, intranasal administration of DSF/HP-β-CD/Cu showed promising therapeutic effects in inhibiting tumor growth and migration, promoting apoptosis, and extending median survival time in rats compared to oral and intravenous administrations. Additionally, no obvious histopathological damage to normal tissues was observed, indicating the potential of DSF/HP-β-CD/Cu as an effective intranasal formulation for GBM treatment.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Riccardo Ferrero, Stefano Pantaleone, Massimo Delle Piane, Fabrizio Caldera, Marta Corno, Francesco Trotta, Valentina Brunella
Summary: In this work, a computational study supported by experimental IR spectra on inclusion MT/beta CD complexes is presented. The aim is to provide a robust, accurate, and low-cost methodology to investigate these inclusion complexes using both static and dynamic simulations, in order to study the main actors driving the interactions of melatonin with beta-cyclodextrin and to understand its release mechanism.
Article
Polymer Science
Kuljit Kaur, Rajeev Jindal, Diksha Saini
Article
Polymer Science
Kuljit Kaur, Rajeev Jindal
Summary: Theophylline and beta-cyclodextrin solid inclusion compounds prepared through microwave irradiation method showed better inclusion effects and controlled release for Theophylline. The drug release kinetics exhibited non-Fickian diffusion at pH 7 and 7.4, but non-Fickian super case II diffusion under acidic conditions. The biodegradable hydrogel networks prepared in air conditions were found to be more efficient in composting process compared to soil burial method.
Article
Pharmacology & Pharmacy
Khushbu, Rajeev Jindal
Summary: This study aimed to prepare inclusion complexes of APB and β-CD for sustained drug release using microwave and kneading methods. Characterization of the APB-β-CD complex was done using H-1 NMR and XRD. The introduction of inclusion complexes improved drug loading in the nanocomposite system.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Medicine, Research & Experimental
Khushbu, Rajeev Jindal
Summary: The study utilized nanocomposites as sustained release formulations for Amoxicillin, confirming that the microwave method was most suitable for preparing exact inclusion complexes of AMX and beta-CD. Analysis of drug release kinetics indicated that the Korsmeyer-Peppas and Peppas-Sahlin models were the best fit for drug release under different conditions. The study also found that beta-CD is capable of causing sustained drug release in a pH-dependent manner.
MOLECULAR PHARMACEUTICS
(2021)
Article
Polymer Science
Vasudha Vaid, Rajeev Jindal
Summary: This study developed an eco-friendly, cost-effective, and efficient adsorbent using a cross-linked 3-D network hydrogel based on kappa-carrageenan (KCG) and tamarind kernel powder (TKP). The hydrogel exhibited a high adsorption capacity for the removal of brilliant green (BG) and rose bengal (RB) dyes from wastewater. The adsorption capacity was influenced by parameters such as dye concentration, pH, temperature, and adsorbent amount. The kinetic, isotherm, and thermodynamic studies showed that the hydrogel followed pseudo-second-order kinetics and the Langmuir isotherm model.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Vasudha Vaid, Rajeev Jindal
Summary: The present research focuses on the synthesis and optimization of a natural polysaccharide-based hydrogel using air and epichlorohydrin as a crosslinker. The study investigates the influence of various process variables on the hydrogel's properties and characterizes the resulting hydrogel and inclusion complexes. The research also explores the controlled release of adenosine under different conditions.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Khushbu, Rajeev Jindal
Summary: The objective of the study is to enhance the solubility and stability of edaravone, a free radical scavenger drug. The inclusion complexes and nanocomposites were prepared and characterized, and their drug release behaviors were investigated. The results demonstrated that the nanocomposites showed better performance in controlled drug release.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Khushbu, Rajeev Jindal
Summary: Natural polysaccharides were used as adsorbents for the removal of toxic dyes. Nanocomposites of chitosan, graphene oxide, sodium alginate, and beta-cyclodextrin were synthesized and their adsorption performance was studied. GO/ALG/CH/beta-CD nanocomposite showed higher adsorption capacity and the adsorption process followed the pseudo-second-order kinetics.
IRANIAN POLYMER JOURNAL
(2022)
Article
Polymer Science
Khushbu, Rajeev Jindal
Summary: This study aimed to prepare an inclusion complex of adenosine (ADS) and beta-cyclodextrin (beta-CD) that can be incorporated into a nanocomposite system for topical administration. Different methods were used to fabricate the inclusion complex, and the effects of bentonite on adenosine release were investigated. Optimization of reaction parameters was carried out using response surface methodology (RSM), and the influence of beta-CD on polymer relaxation and drug release was analyzed.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Polymer Science
Khushbu, Rajeev Jindal
Summary: This study aims to optimize the performance of graphene oxide incorporated chitosan and sodium alginate-based nanocomposite and investigate the drug loading and release behavior of Paracetamol. The results showed that graphene oxide has excellent biocompatibility and high drug loading capacity, and the inclusion interaction with β-CD can slow down the drug release rate.
Article
Polymer Science
Kuljit Kaur, Khushbu, Vasudha Vaid, Anupama, Anshul, Ankush, Rajeev Jindal
Summary: Chitosan- and Carboxymethyl cellulose-based hydrogel materials were synthesized and characterized. These materials showed excellent performance in removing toxic dyes from wastewater.
Article
Materials Science, Textiles
Vasudha Vaid, Kuljit Khushbu, Kuljit Kaur, Anshul Bansal, Ankush Panwar, Anupama Devi, Rajeev Jindal
Summary: In this study, a chitosan and guar gum-based hydrogel crosslinked with glyoxal was synthesized to investigate its adsorption efficiency for organic dye removal. The hydrogel exhibited a maximum swelling capacity of 815% through optimization. Characterization analyses confirmed the successful synthesis of the hydrogel. The adsorption effectiveness of the CH-gl-GG hydrogel for cationic dyes was evaluated and found to have excellent fit to the Langmuir model, demonstrating its potential as an effective and environmentally friendly adsorbent for dye removal from contaminated water.
FIBERS AND POLYMERS
(2023)
