Article
Oncology
Feng Xu, Huan Xu, Zixiong Li, Yuanyuan Huang, Xiaoling Huang, Yangyi Li, Xiaohe Zheng, Yongsong Chen, Ling Lin
Summary: A specific glycolysis-associated risk model was established to predict thyroid cancer patients' survival, showing that the high-risk group had decreased immune score, elevated tumor purity, and worse survival prognosis. The derived glycolysis-related signature serves as an independent prognostic biomarker for thyroid cancer patients and could potentially be utilized for drug-sensitivity prediction.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Han Nie, Cancan Luo, Kaili Liao, Jiasheng Xu, Xiaozhong Wang
Summary: The study identified key glycolysis-related genes in pancreatic ductal carcinoma (PDAC) and constructed a gene model for predicting patient prognosis based on clinical information, which showed high accuracy and correlation with survival time.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Xiaomin Cai, Zheng Chen, Caiquan Huang, Jie Shen, Wenxian Zeng, Shuang Feng, Yu Liu, Shiting Li, Ming Chen
Summary: This study aimed to construct a prognostic signature based on glycolysis-related genes (GRGs) for IDH1-associated glioblastoma multiforme (GBM) and investigate its relationship with immunity. Through genomic data analysis and statistical methods, GRGs that were associated with prognosis were identified and a prognostic signature was constructed. Further validation showed that the prognostic signature independently predicted the prognosis of GBM patients and was significantly correlated with clinical characteristics, tumor immunogenicity, and immune infiltration.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Kaixuan Guo, Cong Lai, Juanyi Shi, Zhuang Tang, Cheng Liu, Kuiqing Li, Kewei Xu
Summary: A risk prediction model based on five glycolysis-related genes was developed using data from TCGA and GEO databases, which accurately predicted the prognosis of PCa patients. In vitro experiments showed that knocking down HMMR, KIF20A, PGM2L1, and ANKZF1 separately reduced glucose consumption, lactic production, and inhibited cell migration and invasion, while knocking down GPR87 had the opposite effect.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Zhongqi Cui, Guifeng Sun, Ramesh Bhandari, Jiayi Lu, Mengmei Zhang, Rajeev Bhandari, Fenyong Sun, Zhongchen Liu, Shasha Zhao
Summary: This study identified 226 dysregulated expression of glycolysis-related genes (DE-GRGs) in colon cancer patients and constructed a prognostic model that accurately predicted overall survival rates. High-risk patients showed higher tumor mutation load and tumor stem cell index, with lower sensitivity to chemotherapy drugs. This multi-omics study provides insights into GRGs' role in colon cancer prognosis and treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ju-Yan Zheng, Jun-Yan Liu, Tao Zhu, Chong Liu, Ying Gao, Wen-Ting Dai, Wei Zhuo, Xiao-Yuan Mao, Bai-Mei He, Zhao-Qian Liu
Summary: The study successfully constructed and verified a novel glycolysis-related risk signature for HCC prognosis prediction, which is meaningful for classifying HCC patients and offers potential targets for the treatment of hepatocellular carcinoma.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Fangxing Xu, Jinglong Yan, Zhibin Peng, Jingsong Liu, Zecheng Li
Summary: In this study, a gene signature related to glycolysis and cholesterol synthesis was constructed to predict the prognosis and guide therapy for osteosarcoma patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Wei He, Xiang He, Enhui Li
Summary: In this study, a reliable prognostic model based on aerobic glycolysis-related genes was established for predicting clinical outcomes and therapeutic responses in prostate cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Yu Zeng, Weike Ma, Lijuan Li, Gaojian Zhuang, Guoqing Luo, Hong Zhou, Weijing Hao, Yu Liu, Fengli Guo, Mengran Tian, Xianhui Ruan, Ming Gao, Xiangqian Zheng
Summary: This study found that estrogen is associated with the development of papillary thyroid cancer (PTC), but the targets and mechanisms of estrogen action in PTC are still unclear. By analyzing genomic databases, differentially expressed estrogen-related genes (ERGs) were identified in PTC, and NMU was found to be one of the genes that most contributed to PTC prognosis. Further research revealed that NMU is highly expressed in PTC and its knockdown significantly inhibits PTC cell proliferation and the phosphorylation levels of the KRAS signaling pathway. These findings suggest that ERGs, particularly NMU, may serve as novel prognostic indicators in PTC.
Article
Biochemistry & Molecular Biology
Nandie Wu, Fangcen Liu, Ying Huang, Xinyu Su, Yaping Zhang, Lixia Yu, Baorui Liu
Summary: The high-risk group of gastric cancer patients showed higher clinical stage or grade and worse prognosis compared to the low-risk group. The low-risk group had higher levels of immunity and immune cell infiltration. Necroptosis was triggered by the TNF pathway in myeloid cells and the glycolysis pathway was altered. In vitro experiments demonstrated that necroptosis-related genes modulated cell function, including proliferation and migration, and the low-risk subgroup showed higher sensitivity to potential drugs. These findings contribute to a better understanding and improvement of treatment potential and prognosis in gastric cancer patients.
Article
Immunology
Yi Liu, Jiandong Wang, Mengxi Jiang
Summary: The relationship between copper homeostasis and breast cancer development is complex. Copper elimination and overload both have therapeutic potential in cancer treatment. This study analyzed the impact of copper-related genes on breast cancer prognosis, immune infiltration, drug sensitivity, and metabolic profile. Immunohistochemistry staining showed high expression of copper-related genes in breast cancer samples, and copper distribution was observed in breast cancer tissue.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Xinyang Zhong, Xuefeng He, Yaxian Wang, Zijuan Hu, Huixia Huang, Senlin Zhao, Hong Zhang, Ping Wei, Dawei Li
Summary: This study identified glycolysis-related long non-coding RNAs (GRLs) and developed a prognostic signature for colorectal cancer. The signature classified the cancer into two molecular subtypes with different prognosis outcomes and excellent diagnostic accuracy. Validation in another cohort confirmed the prognostic value of this signature and revealed significant differences in molecular pathways, immune infiltration, and mutation landscape between the two groups. Different drug sensitivity results suggest a potential strategy for precise treatment.
Review
Biochemistry & Molecular Biology
Adam Maciejewski, Katarzyna Lacka
Summary: Vitamin D plays a crucial role in immunity and differentiation/proliferation processes, and it is potentially associated with thyroid cancer. This study systematically reviewed publications on the association between vitamin D-related gene variants and thyroid cancer. Results were inconclusive, and further validation is required.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Yue Wang, Jing Yang, Shitu Chen, Weibin Wang, Lisong Teng
Summary: The study identified differentially expressed ferroptosis-related genes between normal thyroid tissue and thyroid cancer tissues, developed a prognostic model and nomogram based on these genes to predict the survival rate of thyroid cancer patients, providing new insights into prognosis prediction.
Article
Oncology
N. Evans Harding, Richard Simo, L. Li, P. Maniam, R. Adamson, A. Hay, B. Conn, M. Lyall, I. J. Nixon
Summary: This study aimed to examine the relationship between multifocality and the risk of recurrence in papillary thyroid carcinoma (PTC). The results showed that multifocality itself does not contribute to worse outcomes in PTC, but the presence of 4 or more foci is associated with worse outcomes and may serve as a threshold for treatment intensification.