Article
Cell Biology
Zhiyuan Guan, Shengfu Liu, Liying Luo, Zhong Wu, Shan Lu, Zhiqiang Guan, Kun Tao
Summary: This study investigates the prognosis of sarcoma patients and the genetic marker associated with iron residues. By analyzing gene expression and risk assessment models, the overall survival of patients is predicted. The study also explores the characteristics of the tumor microenvironment related to risk assessment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Hao Zhang, Shuangli Zhu, Haiting Zhou, Rui Li, Xiaohui Xia, Huihua Xiong
Summary: This study found that the expression of Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is upregulated in triple-negative breast cancer (TNBC) and is associated with poor prognosis. MTHFD2 is involved in various tumor-related processes and is closely related to immune cell infiltration. In vitro experiments showed that silencing MTHFD2 inhibits the proliferation, apoptosis, migration, and invasion of TNBC cells, and promotes ferroptosis. Therefore, MTHFD2 could serve as an important molecular biomarker for predicting prognosis and a potential therapeutic target in TNBC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Jianming Wei, Ye Zeng, Xibo Gao, Tong Liu
Summary: In this study, a prognostic ferroptosis-related lncRNA signature was constructed for gastric cancer, with the low-risk group showing significantly better prognosis than the high-risk group. The risk score was identified as an independent prognostic factor. This risk model provides a novel method for predicting prognosis in gastric cancer patients.
Article
Oncology
Jiaxing Guo, Meiyuan Huang, Shuang Deng, Haiyan Wang, Zuli Wang, Bokang Yan
Summary: In this study, we reveal the previously unrecognized role of RPLP2 in HCC and provide a new regulatory mechanism of ferroptosis, indicating that RPLP2 may be a novel therapeutic target for HCC. Elevated level of RPLP2 is strongly associated with advanced clinicopathologic features and predicts poor prognosis of HCC patients. Inhibition of RPLP2 could lead to the acceleration of ferroptosis to suppress tumor progression of HCC. Drug sensitivity analysis predicts many drugs that potentially target RPLP2.
CANCER CELL INTERNATIONAL
(2023)
Article
Oncology
Jihua Yang, XiaoHong Wei, Fang Hu, Wei Dong, Liao Sun
Summary: We present a novel prognostic molecular model for pancreatic adenocarcinoma (PAAD) based on ferroptosis-related genes, which serves as a potentially effective tool for prognostic differentiation in pancreatic cancer patients.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Yamin Rao, Jinchao Zhu, Haiyan Zheng, Wei Dong, Qingyuan Lin
Summary: By bioinformatics analysis, this study identified the expression profile of ferroptosis-related LncRNA genes in melanoma and constructed a prognosis model to assess patients' prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Genetics & Heredity
Ying Song, Shufang Tian, Ping Zhang, Nan Zhang, Yan Shen, Jianchuan Deng
Summary: This study established a novel ferroptosis-related prognostic model for AML, predicting patient survival probability and stratifying risk. It demonstrated significantly prolonged overall survival and lower mortality in the low-risk group, with good predictive accuracy for patient survival.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Yang Teng, Bo Wang, Desi Shang, Ning Yang
Summary: This study developed a combined index of immune and ferroptosis for predicting the prognosis of NSCLC, which showed promising potential in prognosis and therapeutic pathway exploration.
FRONTIERS IN GENETICS
(2021)
Article
Medicine, General & Internal
Mingqin Ge, Jie Niu, Ping Hu, Aihua Tong, Yan Dai, Fangjiang Xu, Fuyuan Li
Summary: A prognostic ferroptosis-related signature involving eight genes was established for predicting the prognosis of thyroid cancer. Patients in the high-risk group had a significantly poorer prognosis compared to those in the low-risk group. The model showed good predictive performance with AUCs of 0.887, 0.890, and 0.840 for 1-, 2-, and 3-year survival, respectively. The signature, in combination with age, successfully predicted survival probabilities for 1-, 3-, and 5-year time points.
FRONTIERS IN MEDICINE
(2021)
Article
Endocrinology & Metabolism
Xiaoying Ren, Huijun Du, Weilun Cheng, Yujing Wang, Yuanxin Xu, Shuang Yan, Yunan Gao
Summary: This study identified eight key genes related to ferroptosis in patients with thyroid cancer. The prognostic risk model based on these genes showed good predictive value for the prognosis of thyroid cancer patients. The study also revealed differences in immune cell infiltration between high and low risk groups, indicating the potential role of immune response in thyroid cancer prognosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Surgery
Konjeti R. Sekhar, Sriram Cyr, Naira Baregamian
Summary: This study examines the differential effects of GPX4 inhibitors on thyroid cancer cells and 3D spheroid models, and finds that the inhibitors can induce ferroptosis, increase DNA damage, and have different responses in different cell models. Our study is the first to determine the differential effects of GPX4 inhibitors on thyroid cancer cells with diverse mutational signatures.
WORLD JOURNAL OF SURGERY
(2023)
Article
Oncology
Jinyuan Shi, Pu Wu, Lei Sheng, Wei Sun, Hao Zhang
Summary: This study identified a novel ferroptosis-related gene signature with 10 genes in PTC, which showed predictive value for patients' prognosis. High-risk and low-risk groups based on the signature had different survival rates, and the risk score was identified as an independent prognostic indicator. Functional roles of the differentially expressed genes were explored through GO enrichment and KEGG pathway analyses. Immune-related analysis showed significant differences in immune cell types and functions between high-risk and low-risk groups, and qRT-PCR confirmed expression differences of the genes in tumor tissue and normal thyroid tissue.
CANCER CELL INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Huijun Du, Yumei Tang, Xiaoying Ren, Fan Zhang, Wei Yang, Le Cheng, Yunan Gao
Summary: A prognostic model based on the expression of ferroptosis-related genes was constructed, showing good predictive performance. The mechanism of ferroptosis in cervical cancer was identified, and potential therapeutic targets were revealed.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xin Fan, Fei Xie, Lingling Zhang, Chang Tong, Zhiyuan Zhang
Summary: This study investigates the relationship between ferroptosis, immunity, and the prognosis of thyroid carcinoma (THCA) through the establishment of a prognostic model. The results suggest that ferroptosis and immunity are closely related to the prognosis of THCA. Additionally, copy number variations and regulatory networks involving CDKN2A may also impact the progression and prognosis of THCA.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Yixian He, Yunyang Wu, Mengqi Song, Yanlong Yang, Yizhi Yu, Sheng Xu
Summary: This study constructed a prognostic model for patients with HCC based on five ferroptosis genes, using the FerrDb database and the TCGA database. The model was proven to have independent prognostic value and can also serve as a biomarker for immunotherapy response. Experimental results showed differential expression of these genes between tumor and normal tissues.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yue Wang, Jing-lin Wang, Hu-cheng Ma, Zhen-ting Tang, Hao-ran Ding, Xiao-lei Shi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Physiology
Hao-ran Ding, Jing-lin Wang, Zhen-ting Tang, Yue Wang, Guang Zhou, Yang Liu, Hao-zhen Ren, Xiao-lei Shi
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Endocrinology & Metabolism
Yunjin Yao, Peiwei Xu, Tianxing Ying, Yue Wang, Xumeng Wang, Liqi Shu, Zhe Mo, Zhijian Chen, Xiaofeng Wang, Weibin Wang, Lisong Teng, Xiaoming Lou
Summary: This study conducted an integrative analysis of DNA methylation and RNA array data to identify thyroid cancer-specific DNA methylation markers, providing potential molecular markers for early diagnosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)