Therapeutic Targeting Hypoxia-Inducible Factor (HIF-1) in Cancer: Cutting Gordian Knot of Cancer Cell Metabolism

Molecular mechanism(s) of regulation(s) of c-MET/HGF signaling in head and neck cancer

(2022) Sibi Raj et al.   Molecular Cancer

Hallmarks of Cancer: New Dimensions

(2022) Douglas Hanahan   Cancer Discovery

Tumor Hypoxia Regulates Immune Escape/Invasion: Influence on Angiogenesis and Potential Impact of Hypoxic Biomarkers on Cancer Therapies

(2021) Raefa Abou Khouzam et al.   Frontiers in Immunology

Hypoxia-Induced Epithelial-Mesenchymal Transition in Cancers: HIF-1α and Beyond

(2020) Shing Yau Tam et al.   Frontiers in Oncology

Tumor Hypoxia: Impact on Radiation Therapy and Molecular Pathways

(2020) Brita Singers Sørensen et al.   Frontiers in Oncology

Targeting the HGF/MET Axis in Cancer Therapy: Challenges in Resistance and Opportunities for Improvement

(2020) Xing Huang et al.   Frontiers in Cell and Developmental Biology

Revisiting the Warburg effect: historical dogma versus current understanding

(2020) Peter Vaupel et al.   JOURNAL OF PHYSIOLOGY-LONDON

Anticancer Activity of Natural Flavonoids: Inhibition of HIF-1α Signaling Pathway

(2019) Xiangping Deng et al.   CURRENT ORGANIC CHEMISTRY

Baicalein and baicalin inhibit colon cancer using two distinct fashions of apoptosis and senescence

(2018) Jie Dou et al.   Oncotarget

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

(2016) Caroline Wigerup et al.   PHARMACOLOGY & THERAPEUTICS

Novel HSP90 inhibitors effectively target functions of thyroid cancer stem cell preventing migration and invasion

(2016) Peter T. White et al.   SURGERY

Axitinib plasma pharmacokinetics and ethnic differences

(2015) Ying Chen et al.   INVESTIGATIONAL NEW DRUGS

Hypoxia Induces Epithelial-Mesenchymal Transition in Follicular Thyroid Cancer: Involvement of Regulation of Twist by Hypoxia Inducible Factor-1α

(2015) Yeon Ju Yang et al.   YONSEI MEDICAL JOURNAL

Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization

(2015) L Wei et al.   Cell Death & Disease

Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition

(2015) Ioanna Ledaki et al.   Oncotarget

The Paradox of E-Cadherin: Role in response to hypoxia in the tumor microenvironment and regulation of energy metabolism

(2015) Khoi Chu et al.   Oncotarget

Hypoxia-Inducible Factor-1 Promotes Pancreatic Ductal Adenocarcinoma Invasion and Metastasis by Activating Transcription of the Actin-Bundling Protein Fascin

(2014) X. Zhao et al.   CANCER RESEARCH

Hypoxia-mediated CD24 expression is correlated with gastric cancer aggressiveness by promoting cell migration and invasion

(2014) Nobuaki Fujikuni et al.   CANCER SCIENCE

The interplay between hypoxia, endothelial and melanoma cells regulates vascularization and cell motility through endothelin-1 and vascular endothelial growth factor

(2014) Francesca Spinella et al.   CARCINOGENESIS

Heat shock protein 90 inhibitors in non-small-cell lung cancer

(2014) Rathi N. Pillai et al.   CURRENT OPINION IN ONCOLOGY

Hypoxia induces resistance to ALK inhibitors in the H3122 non-small cell lung cancer cell line with an ALK rearrangement via epithelial-mesenchymal transition

(2014) AKIHIRO KOGITA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hypoxia-induced autophagy contributes to radioresistance via c-Jun-mediated Beclin1 expression in lung cancer cells

(2014) Yan-mei Zou et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Krüppel-like factor 8 involved in hypoxia promotes the invasion and metastasis of gastric cancer via epithelial to mesenchymal transition

(2014) NA LIU et al.   ONCOLOGY REPORTS

Baicalein reverses hypoxia-induced 5-FU resistance in gastric cancer AGS cells through suppression of glycolysis and the PTEN/Akt/HIF-1α signaling pathway

(2014) FENGLIN CHEN et al.   ONCOLOGY REPORTS

Upregulation of autophagy by hypoxia-inducible factor-1α promotes EMT and metastatic ability of CD133+ pancreatic cancer stem-like cells during intermittent hypoxia

(2014) HAITAO ZHU et al.   ONCOLOGY REPORTS

CypA, a Gene Downstream of HIF-1α, Promotes the Development of PDAC

(2014) Huan Zhang et al.   PLoS One

Expression of monocyte chemotactic protein-1/CCL2 in gastric cancer and its relationship with tumor hypoxia

(2014) Lei-Lei Tao   WORLD JOURNAL OF GASTROENTEROLOGY

Hypoxia-Inducible lncRNA-AK058003 Promotes Gastric Cancer Metastasis by Targeting γ-Synuclein

(2014) Yafang Wang et al.   NEOPLASIA

A Mechanism of Hypoxia-Mediated Escape from Adaptive Immunity in Cancer Cells

(2013) I. B. Barsoum et al.   CANCER RESEARCH

Targeting Epithelial-to-Mesenchymal Transition with Met Inhibitors Reverts Chemoresistance in Small Cell Lung Cancer

(2013) I. Canadas et al.   CLINICAL CANCER RESEARCH

Targeting the HGF/c-MET Pathway in Hepatocellular Carcinoma

(2013) L. Goyal et al.   CLINICAL CANCER RESEARCH

Hypoxia-Targeting Carbonic Anhydrase IX Inhibitors by a New Series of Nitroimidazole-Sulfonamides/Sulfamides/Sulfamates

(2013) Marouan Rami et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer

(2013) Lisha Xiang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Resveratrol Suppresses Cancer Cell Glucose Uptake by Targeting Reactive Oxygen Species-Mediated Hypoxia-Inducible Factor-1  Activation

(2013) K.-H. Jung et al.   JOURNAL OF NUCLEAR MEDICINE

Hypoxia Stimulates the EMT of Gastric Cancer Cells through Autocrine TGFβ Signaling

(2013) Junko Matsuoka et al.   PLoS One

Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features

(2012) A. K. Azab et al.   BLOOD

Tryptophan Catabolism in Cancer: Beyond IDO and Tryptophan Depletion

(2012) M. Platten et al.   CANCER RESEARCH

Hedgehog inhibitor decreases chemosensitivity to 5-fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancer

(2012) Hideya Onishi et al.   CANCER SCIENCE

Tumor cycling hypoxia induces chemoresistance in glioblastoma multiforme by upregulating the expression and function of ABCB1

(2012) Chii-Wen Chou et al.   NEURO-ONCOLOGY

Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche

(2012) F E Lock et al.   ONCOGENE

Hypoxia induces CXCR4 expression and biological activity in gastric cancer cells through activation of hypoxia-inducible factor-1α

(2012) YOON SUK OH et al.   ONCOLOGY REPORTS

Hypoxia Regulates CD44 and Its Variant Isoforms through HIF-1α in Triple Negative Breast Cancer

(2012) Balaji Krishnamachary et al.   PLoS One

Snail1 Mediates Hypoxia-Induced Melanoma Progression

(2011) Shujing Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Molecular Pathways: Hypoxia Response in Immune Cells Fighting or Promoting Cancer

(2011) Asis Palazón et al.   CLINICAL CANCER RESEARCH

Glycosyl Coumarin Carbonic Anhydrase IX and XII Inhibitors Strongly Attenuate the Growth of Primary Breast Tumors

(2011) Nadia Touisni et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Macrophage Expression of Hypoxia-Inducible Factor-1  Suppresses T-Cell Function and Promotes Tumor Progression

(2010) A. L. Doedens et al.   CANCER RESEARCH

Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation

(2010) Hongxia Z. Imtiyaz et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

(2010) Cesar A. Corzo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer

(2010) Eunice L. Kwak et al.   NEW ENGLAND JOURNAL OF MEDICINE

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

(2010) A Singh et al.   ONCOGENE

Polyamine catabolism and disease

(2009) Robert A. Casero et al.   BIOCHEMICAL JOURNAL

The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy

(2009) E Y Tan et al.   BRITISH JOURNAL OF CANCER

HIF-1α and Calcium Signaling as Targets for Treatment of Prostate Cancer by Cardiac Glycosides

(2009) J. Lin et al.   CURRENT CANCER DRUG TARGETS

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF-1α Modulates Energy Metabolism in Cancer Cells by Inducing Over-Expression of Specific Glycolytic Isoforms

(2009) Alvaro Marin-Hernandez et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Hypoxia-inducible factor 1 alpha expression increases during colorectal carcinogenesis and tumor progression

(2008) Nektaria Simiantonaki et al.   BMC CANCER

Tumor-derived tumor necrosis factor-alpha promotes progression and epithelial-mesenchymal transition in renal cell carcinoma cells

(2008) Mei-Jen Chuang et al.   CANCER SCIENCE

Methylalpinumisoflavone Inhibits Hypoxia-inducible Factor-1 (HIF-1) Activation by Simultaneously Targeting Multiple Pathways

(2008) Yang Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiac Glycosides as Novel Cancer Therapeutic Agents

(2008) R. A. Newman et al.   MOLECULAR INTERVENTIONS

Direct regulation of TWIST by HIF-1α promotes metastasis

(2008) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY

Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth

(2008) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria in cancer: Not just innocent bystanders

(2008) Christian Frezza et al.   SEMINARS IN CANCER BIOLOGY

Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapy

(2008) Saroj P. Mathupala et al.   SEMINARS IN CANCER BIOLOGY

Mitochondria as targets for cancer chemotherapy

(2008) Vladimir Gogvadze et al.   SEMINARS IN CANCER BIOLOGY