Article
Hematology
Kyle T. Wright, Jason L. Weirather, Sizun Jiang, Katrina Z. Kao, Yari Sigal, Anita Giobbie-Hurder, Margaret A. Shipp, Scott J. Rodig
Summary: By studying 51 newly diagnosed DLBCL cases, it was found that the organization of tumor and immune cells can be modeled by 6 composite cell neighborhood types (CNTs) and divided into immune-deficient, DC-enriched, and Mac-enriched TIMEs. Through the analysis of this organization structure, the cellular composition and spatial distribution characteristics of DLBCL can be understood.
Review
Oncology
Eric M. Bressler, Sarah Adams, Rong Liu, Yolonda L. Colson, Wilson W. Wong, Mark W. Grinstaff
Summary: The intersection of synthetic biology and biomaterials holds great promise for improving safety and efficacy in novel therapeutics. Recent research has shown that the use of Boolean logic in these fields can lead to the development of new and effective living therapeutics, such as stimuli-responsive drug delivery devices and logic-gated CAR T cells. Collaborations between synthetic biology and biomaterials have resulted in advancements in drug delivery and cell therapy, with potential benefits including enhanced safety and efficacy.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Pedro Lavrador, Vitor M. Gaspar, Joao F. Mano
Summary: Engineered living materials are a new generation of human-made biotherapeutics with attractive features, providing encodable bioactivities, extended lifetimes, and environmental adaptability. Novel cell bioengineering tools are driving the assembly of multiscale living materials by utilizing living cells as cooperative building blocks. These materials have the potential to improve precision and personalized medicine strategies in the future.
Article
Geriatrics & Gerontology
Jean Daly-Lynn, Assumpta Ryan, Brendan McCormack, Suzanne Martin
Summary: This study examines the experiences of people with dementia living in technology enriched care models and explores caregiver attitudes towards technology use. The findings suggest that technology innovation can provide support for people living with dementia and their caregivers.
Article
Chemistry, Analytical
Isamar Pastrana-Otero, Sayani Majumdar, Aidan E. Gilchrist, Brendan A. C. Harley, Mary L. Kraft
Summary: This study demonstrates that a combination of Raman microspectroscopy and partial least squares discriminant analysis (PLS-DA) can be used to location-specifically identify individual living cells from the six most immature hematopoietic cell populations. By utilizing spectral features associated with cell biochemistries, the differentiation stages of cells can be accurately identified.
ANALYTICAL CHEMISTRY
(2022)
Review
Developmental Biology
Wanglong Xiao, Mengdi Yu, Yan Yuan, Xingzhu Liu, Ying Chen
Summary: This article discusses mammalian sperm thermotaxis, including the underlying behavioral mechanisms and molecular basis, and explores the potential application of sperm thermotaxis in assisted reproductive technologies.
MOLECULAR HUMAN REPRODUCTION
(2022)
Article
Chemistry, Physical
Lu Wang, Zhenxuan Fei, Youchao Qi, Chi Zhang, Libo Zhao, Zhuangde Jiang, Ryutaro Maeda
Summary: This article reviews the energy harvesting technologies from human motions, including electromagnetic, piezoelectric, and triboelectric techniques. It discusses the advantages and disadvantages of various human energy harvesters and explores the possible applications in active sensing and wearable electronic devices. Additionally, it proposes the concept of a human energy and information exchange center based on energy harvesting.
ACS APPLIED ENERGY MATERIALS
(2022)
Review
Developmental Biology
Grace Hancock, Sissy E. Wamaitha, Lior Peretz, Amander T. Clark
Summary: The peri-implantation window of mammalian development is crucial for primordial germ cell (PGC) specification. While preimplantation dynamics are relatively conserved between species, the implantation window marks a stage of developmental divergence, requiring the combined use of human and nonhuman primate embryos to determine the origin of PGCs.
Article
Green & Sustainable Science & Technology
X. Cheng, P. K. Singh, A. Mishra, A. Tiwari, W. Ren
Summary: This article reviews the potential of wurtzite structures, especially intrinsic piezoelectric semiconductors, for energy harvesting at different scales and morphologies (3D, 2D, and 1D). The characteristics, synthesis methods, and application scope of wurtzite structures are discussed systematically, along with the opportunities and challenges in piezoelectric nanoenergy harvesting systems based on wurtzite structures. The study emphasizes the significance of wurtzite structures as candidates for renewable energy generation.
MATERIALS TODAY SUSTAINABILITY
(2023)
Article
Chemistry, Analytical
Geetanjali Basavaraj Hubli, Shantanu Banerjee, Anurag S. Rathore
Summary: In this study, a robust FT-NIR based quantification method has been developed for the measurement of all 20 amino acids, glucose, lactate, and trastuzumab in CHO cell culture. The method achieved good calibration statistics and demonstrated the ability to accurately predict the concentrations of these components. The proposed tool has the potential to play a critical role in biopharmaceutical manufacturing and process control.
Article
Cell Biology
Daniel Palmer, Fabio Fabris, Aoife Doherty, Alex A. Freitas, Joao Pedro de Magalhaes
Summary: The study conducted a meta-analysis on transcriptomic data from mice, rats, and humans, identifying a transcriptomic signature of ageing across species and tissues. The analysis revealed overexpression of immune and stress response genes and underexpression of metabolic and developmental genes in different tissues, along with little overlap between genes differentially expressed with age in different tissues. Additionally, it was found that ageing gene expression signatures in the brain and muscle tend to include genes central in protein-protein interaction networks, and genes underexpressed with age in the brain may have broad phenotypic consequences.
Article
Biochemical Research Methods
Suyang Wu, Stephanie A. Ketcham, Claudia C. C. Corredor, Douglas Both, James K. K. Drennen, Carl A. A. Anderson
Summary: This study transferred an at-line model to monitor lab-scale bioreactors in real-time, eliminating the need for frequent sampling and enabling precise controls. A new model was constructed, improving prediction accuracy and reducing prediction bias. The RMSE of the final model was 6.56% with an R-2 of 92.4%.
BIOTECHNOLOGY JOURNAL
(2023)
Article
Environmental Sciences
Hongyan Guo, Jian Ji, Jiadi Sun, Yinzhi Zhang, Xiulan Sun
Summary: A biosensor based on living mammary cells was developed for monitoring the combined toxicity of cadmium and deoxynivalenol in water, showing enhanced toxicity compared to individual toxins. The biosensor offers advantages such as easy screening of multiple toxins, potential for broad-spectrum joint toxicity evaluation, pollution-free and stable fluorescence response, and minimal impact on viability.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Multidisciplinary
Xiaomin Qian, Isabella Nymann Westensee, Catarina Cavalheiro Fernandes, Brigitte Stadler
Summary: This study demonstrates the use of artificial enzymes to facilitate signal transfer between artificial cells and mammalian cells, opening up new opportunities for integrating the synthetic and living worlds with a bottom-up strategy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Stephen P. Burr, Florian Klimm, Angelos Glynos, Malwina Prater, Pamella Sendon, Pavel Nash, Christopher A. Powell, Marie-Lune Simard, Nina A. Bonekamp, Julia Charl, Hector Diaz, Lyuba V. Bozhilova, Yu Nie, Haixin Zhang, Michele Frison, Maria Falkenberg, Nick Jones, Michal Minczuk, James B. Stewart, Patrick F. Chinnery
Summary: Mitochondrial activity varies between organs, and lineage-specific expression profiles of essential mitochondrial genes emerge early in mouse development. Disrupting intra-mitochondrial protein synthesis with mtDNA mutations induces cell lineage-specific compensatory responses, including novel molecular pathways not previously associated with organellar maintenance. These compensatory pathways, regulated by transcription factors promoting organelle resilience, contribute to tissue specificity in mitochondrial diseases and may be potential targets for organ-directed treatments.
Article
Chemistry, Applied
Hichem Moulahoum, Faezeh Ghorbanizamani, Serhan Sakarya, Suna Timur
Summary: Chitosan-based materials are widely used in various industries due to their environmental friendliness and antimicrobial properties. The addition of titanium dioxide and other nanoparticles has been shown to improve the performance of chitosan. In this study, chitosan-TiO2 nanocomposites with various metal ions were synthesized to create novel chitosan-based films with enhanced capacities. The films exhibited increased antioxidant activities, dye degradation capabilities, and antimicrobial activities. The most significant finding was that the films were able to perform their activities without the need for light activation, making them promising for various applications.
PROGRESS IN ORGANIC COATINGS
(2022)
Review
Chemistry, Analytical
Tutku Beduk, Duygu Beduk, Mohd Rahil Hasan, Emine Guler Celik, Jurgen Kosel, Jagriti Narang, Khaled Nabil Salama, Suna Timur
Summary: Smartphones with multiplexed sensors have the potential to provide personalized and early diagnostic methods for healthcare. The portability and accessibility of smartphones make them suitable for on-site detection analysis and fast, accurate disease diagnosis.
Review
Nanoscience & Nanotechnology
Abdellatif Ait Lahcen, Sandeep G. Surya, Tutku Beduk, Mani Teja Vijjapu, Abderrahman Lamaoui, Ceren Durmus, Suna Timur, Osama Shekhah, Veerappan Mani, Aziz Amine, Mohamed Eddaoudi, Khaled Nabil Salama
Summary: This review provides a detailed account of the application of the synergistic combination of molecularly imprinted polymers (MIPs) and porous materials in sensor platform development. The synthesis processes and intrinsic properties of MOF/COF-MIPs are outlined, and the impact of morphological changes arising from the synergistic combination compared to individual entities is discussed. The strategies and transduction modes used for building sensors are also overviewed and discussed. The research further highlights the application of MOF/COF-MIP-based (bio)sensors in environmental monitoring, food safety, and pharmaceutical analysis.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Biophysics
Veerappan Mani, Ceren Durmus, Walaa Khushaim, Daisy Camargo Ferreira, Suna Timur, Fabiana Arduini, Khaled Nabil Salama
Summary: Cardiovascular diseases are a leading cause of death worldwide, and timely diagnosis relies on accurate determination of cardiac biomarkers. Multiplexed biosensors targeting multiple markers have emerged as a promising alternative to single-marker analysis. This study critically reviewed various multiplexed biosensing approaches, categorized them by signal readouts, and discussed their advantages, limitations, and future prospects.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Gulsah Bor, Umut Bulut, Ezgi Man, Simge Balaban Hanoglu, Serap Evran, Suna Timur
Summary: An aptamer-based electrochemical biosensor was developed for the analysis of methamphetamine. The sensor exhibited good selectivity and a low limit of detection, making it suitable for the detection of methamphetamine in synthetic urine samples.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Faezeh Ghorbanizamani, Hichem Moulahoum, Emine Guler Celik, Suna Timur
Summary: A novel ionogel modification approach for SPE surface to detect methamphetamine in human saliva was proposed. The optimized sensor showed good detection performance in PBS. The biosensor exhibited high specificity and sensitivity.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Review
Chemistry, Inorganic & Nuclear
Simge Balaban Hanoglu, Duygu Harmanci, Nursima Ucar, Serap Evran, Suna Timur
Summary: In recent years, magnetic nanoparticles (MNPs) have been widely used in various fields, including cancer detection, due to their beneficial properties. Detecting microRNAs (miRNAs) in biological samples is challenging, but MNPs provide an effective solution with their large surface areas and magnetic moments. This article discusses the synthesis and characterization methods of MNPs and their application in miRNA detection using biosensing systems, considering the challenges and prospects in terms of development stages, sensitivity, and selectivity.
Article
Chemistry, Analytical
Huseyin Furkan Kiyikci, Okan Avci, Yudum Tepeli Buyuksunetci, Suna Timur, Ulku Anik
Summary: A facile amperometric biosensor was developed using a Co/2Fe metal-organic framework (MOF) with oxidase mimicking properties for the detection of sialic acid (SA). The biosensor was constructed by immobilizing Co/2Fe MOF and N-acetylneuraminic Acid Aldolase (NANA-Aldolase) enzyme on a gold screen-printed electrode. The sensor showed a linear range of 0.02 mM-1.00 mM for SA concentration and a limit of detection of 0.026 mM. The developed biosensor was successfully applied for the detection of SA in GD3 ganglioside and HeLa cancer cell lines, providing a more practical and accurate system.
Review
Chemistry, Multidisciplinary
Faezeh Ghorbanizamani, Hichem Moulahoum, Emine Guler Celik, Suna Timur
Summary: The growing demand for personalized treatments and constant vital signs observation has led to the development of implantable biosensors that can temporarily or permanently be introduced into the human body. However, ensuring reliable functionality in the complex environment of the human body remains a critical challenge.
APPLIED SCIENCES-BASEL
(2023)
Review
Chemistry, Analytical
Bilge Asci Erkocyigit, Ozge Ozufuklar, Aysenur Yardim, Emine Guler Celik, Suna Timur
Summary: Microfluidics plays a crucial role in lab-on-a-chip systems, allowing for manipulation of fluid behavior and control on a small platform. Paper-based microfluidic analytical devices (muPADs) have numerous advantages, especially in cancer biomarker detection, and have the potential to improve diagnosis and treatment outcomes.
Review
Chemistry, Analytical
Faezeh Ghorbanizamani, Hichem Moulahoum, Emine Guler Celik, Figen Zihnioglu, Tutku Beduk, Tuncay Goksel, Kutsal Turhan, Suna Timur
Summary: Minimally invasive approaches in cancer diagnosis, such as liquid biopsies using blood samples, provide valuable information about the tumor and its state. However, isolating and detecting markers in complex matrices is challenging. Advances in polymer synthesis have led to enhanced platforms for liquid biopsies analysis, improving biosensor performance through increased sensitivity, improved binding, and avoidance of non-specific interactions. Additionally, polymer-based materials aid in signal amplification for low-concentration targets. This technology plays an essential role in oncology and clinical biomedicine, as shown by its critical application in liquid biopsies diagnosis.
Review
Nanoscience & Nanotechnology
Mohd. Rahil Hasan, Pradakshina Sharma, Shariq Suleman, Shouvik Mukherjee, Emine Guler Celik, Suna Timur, Roberto Pilloton, Jagriti Narang
Summary: Integrating electronic applications with paper can expand the uses of paper substrates, but putting electronics on paper is not easy. However, methods like building electronic devices on a rough, absorbent surface of the paper have made significant progress in paper electronics.
ACS APPLIED BIO MATERIALS
(2023)
Review
Nanoscience & Nanotechnology
Mohd Rahil Hasan, Pradakshina Sharma, Shariq Suleman, Shouvik Mukherjee, Emine Guler Celik, Suna Timur, Roberto Pilloton, Jagriti Narang
Summary: Integrating electronic applications with paper substrates can expand the potential uses of paper. While paper has advantages such as being disposable, inexpensive, and environmentally friendly, its rough and porous surface poses a challenge for putting electronics on paper. However, there are methods to make electronic devices compatible with the absorbent surface of paper.
ACS APPLIED BIO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Abdellatif Ait Lahcen, Sandeep G. Surya, Tutku Beduk, Mani Teja Vijjapu, Abderrahman Lamaoui, Ceren Durmus, Suna Timur, Osama Shekhah, Veerappan Mani, Aziz Amine, Mohamed Eddaoudi, Khaled Nabil Salama
Summary: This review provides a detailed overview of the value of using porous materials as the core for synthesizing MIPs, covering the application of MOFs and COFs in developing sensor platforms. It discusses the synthesis process, the impact of morphological changes, and strategies for building sensors. The research advancements and applications of various types of MOF/COF-MIP-based sensors in environmental monitoring, food safety, and pharmaceutical analysis are described. The challenges and prospects of this research field are also discussed in detail.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Kevser Kusat, Serdar Sanli, Suna Timur, Sinan Akgol
Summary: Folic acid plays a crucial role in metabolism, and deficiencies in folic acid metabolism can lead to various disorders. This study developed a nanosensor for the determination of folic acid in commercially human blood serum, demonstrating a novel, simple, selective, and rapid approach.
TURKISH JOURNAL OF CHEMISTRY
(2022)
