Allosteric Regulation of IGF2BP1 as a Novel Strategy for the Activation of Tumor Immune Microenvironment

The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation

(2021) Timothy D. Martin et al.   SCIENCE

Real-world data analyses unveiled the immune-related adverse effects of immune checkpoint inhibitors across cancer types

(2021) Feicheng Wang et al.   npj Precision Oncology

Hematologic complications of immune checkpoint inhibitors

(2021) Michael H Kroll et al.   BLOOD

MYC, MYCL, and MYCN as therapeutic targets in lung cancer

(2020) Daniel Massó-Vallés et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability

(2020) Tamsin J Samuels et al.   eLife

Accelerating the Development of Personalized Cancer Immunotherapy by Integrating Molecular Patients’ Profiles with Dynamic Mathematical Models

(2020) Zvia Agur et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Natural killer cells in cancer biology and therapy

(2020) Song-Yang Wu et al.   Molecular Cancer

The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer

(2020) Simon Müller et al.   NUCLEIC ACIDS RESEARCH

Translation control of the immune checkpoint in cancer and its therapeutic targeting

(2019) Yichen Xu et al.   NATURE MEDICINE

IMP1 KH1 and KH2 domains create a structural platform with unique RNA recognition and re-modelling properties

(2019) Robert Dagil et al.   NUCLEIC ACIDS RESEARCH

Harnessing innate immunity in cancer therapy

(2019) Olivier Demaria et al.   NATURE

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in cancer

(2018) Xinwei Huang et al.   Journal of Hematology & Oncology

Targeting MYC in multiple myeloma

(2018) K. K. Jovanović et al.   LEUKEMIA

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

(2018) Huilin Huang et al.   NATURE CELL BIOLOGY

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

IGF2BP1 promotes SRF-dependent transcription in cancer in a m6A- and miRNA-dependent manner

(2018) Simon Müller et al.   NUCLEIC ACIDS RESEARCH

PD-L1 is commonly expressed and transcriptionally regulated by STAT3 and MYC in ALK-negative anaplastic large-cell lymphoma

(2017) V Atsaves et al.   LEUKEMIA

A Novel IMP1 Inhibitor, BTYNB, Targets c-Myc and Inhibits Melanoma and Ovarian Cancer Cell Proliferation

(2017) Lily Mahapatra et al.   Translational Oncology

Mechanism of β-actin mRNA Recognition by ZBP1

(2017) Giuseppe Nicastro et al.   Cell Reports

Insulin-Like Growth Factor 2 - The Oncogene and its Accomplices

(2016) Sonja Kessler et al.   CURRENT PHARMACEUTICAL DESIGN

Advances in identification and validation of protein targets of natural products without chemical modification

(2016) J. Chang et al.   NATURAL PRODUCT REPORTS

MYC regulates the antitumor immune response through CD47 and PD-L1

(2016) S. C. Casey et al.   SCIENCE

Covalent inhibitors in drug discovery: from accidental discoveries to avoided liabilities and designed therapies

(2015) Renato A. Bauer   DRUG DISCOVERY TODAY

Two Isoforms of the RNA Binding Protein, Coding Region Determinant-binding Protein (CRD-BP/IGF2BP1), Are Expressed in Breast Epithelium and Support Clonogenic Growth of Breast Tumor Cells

(2015) Saja A. Fakhraldeen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions

(2015) Nian Liu et al.   NATURE

N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells

(2014) Yang Wang et al.   NATURE CELL BIOLOGY

Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains

(2013) Kristin Wächter et al.   BIOLOGICAL CHEMISTRY

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?

(2012) Jessica L. Bell et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

KH domains with impaired nucleic acid binding as a tool for functional analysis

(2012) David Hollingworth et al.   NUCLEIC ACIDS RESEARCH

IMP-1 Displays Cross-Talk with K-Ras and Modulates Colon Cancer Cell Survival through the Novel Proapoptotic Protein CYFIP2

(2011) P. S. Mongroo et al.   CANCER RESEARCH

Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery

(2010) T. Kenakin et al.   PHARMACOLOGICAL REVIEWS