MG53 preserves mitochondrial integrity of cardiomyocytes during ischemia reperfusion-induced oxidative stress

Emerging Role of Mitophagy in the Heart: Therapeutic Potentials to Modulate Mitophagy in Cardiac Diseases

(2021) Yi Luan et al.   Oxidative Medicine and Cellular Longevity

MG53 E3 Ligase–Dead Mutant Protects Diabetic Hearts From Acute Ischemic/Reperfusion Injury and Ameliorates Diet-Induced Cardiometabolic Damage

(2021) Han Feng et al.   DIABETES

MG53 does not manifest the development of diabetes in db/db mice

(2020) Qiang Wang et al.   DIABETES

Mitochondria in acute myocardial infarction and cardioprotection

(2020) Chrishan J.A. Ramachandra et al.   EBioMedicine

Dysregulated mitochondrial Ca2+ and ROS signaling in skeletal muscle of ALS mouse model

(2019) Jingsong Zhou et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Mortality From Ischemic Heart Disease

(2019) Alexandra N. Nowbar et al.  

Role of Cardiolipin in Mitochondrial Function and Dynamics in Health and Disease: Molecular and Pharmacological Aspects

(2019) Giuseppe Paradies et al.   Cells

Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function

(2019) Zehua Bian et al.   Nature Communications

ALS-associated mutation SOD1 G93A leads to abnormal mitochondrial dynamics in osteocytes

(2018) Huan Wang et al.   BONE

Irisin Protects Heart Against Ischemia-Reperfusion Injury Through a SOD2-Dependent Mitochondria Mechanism

(2018) Zhen Wang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

ROS-related mitochondrial dysfunction in skeletal muscle of an ALS mouse model during the disease progression

(2018) Yajuan Xiao et al.   PHARMACOLOGICAL RESEARCH

A fluorescence-based imaging method to measure in vitro and in vivo mitophagy using mt-Keima

(2017) Nuo Sun et al.   Nature Protocols

Lack of MG53 in human heart precludes utility as a biomarker of myocardial injury or endogenous cardioprotective factor

(2016) Frances A. Lemckert et al.   CARDIOVASCULAR RESEARCH

Exposure of phosphatidylserine on the cell surface

(2016) S Nagata et al.   CELL DEATH AND DIFFERENTIATION

MG53 permeates through blood-brain barrier to protect ischemic brain injury

(2016) Yonggang Yao et al.   Oncotarget

Cardioprotection of recombinant human MG53 protein in a porcine model of ischemia and reperfusion injury

(2015) Jianxun Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitoflash altered by metabolic stress in insulin-resistant skeletal muscle

(2015) Yi Ding et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Amelioration of ischemia-reperfusion-induced muscle injury by the recombinant human MG53 protein

(2015) Hua Zhu et al.   MUSCLE & NERVE

Effect of Metabolic Syndrome on Mitsugumin 53 Expression and Function

(2015) Hanley Ma et al.   PLoS One

Targeted disruption of PDE3B, but not PDE3A, protects murine heart from ischemia/reperfusion injury

(2015) Youn Wook Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MG53-mediated cell membrane repair protects against acute kidney injury

(2015) Pu Duann et al.   Science Translational Medicine

Redox mechanisms of cardiomyocyte mitochondrial protection

(2015) Raquel R. Bartz et al.   Frontiers in Physiology

Treatment of acute lung injury by targeting MG53-mediated cell membrane repair

(2014) Yanlin Jia et al.   Nature Communications

MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling

(2013) Jae-Sung Yi et al.   Nature Communications

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Recombinant MG53 Protein Modulates Therapeutic Cell Membrane Repair in Treatment of Muscular Dystrophy

(2012) N. Weisleder et al.   Science Translational Medicine

Redox-dependent oligomerization through a leucine zipper motif is essential for MG53-mediated cell membrane repair

(2011) Moonsun Hwang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

MG53 participates in ischaemic postconditioning through the RISK signalling pathway

(2011) Yan Zhang et al.   CARDIOVASCULAR RESEARCH

Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals

(2011) Huaqiang Fang et al.   CELL RESEARCH

MG53 Constitutes a Primary Determinant of Cardiac Ischemic Preconditioning

(2010) Chun-Mei Cao et al.   CIRCULATION

Cardioprotection of Ischemia/Reperfusion Injury by Cholesterol-Dependent MG53-Mediated Membrane Repair

(2010) Xianhua Wang et al.   CIRCULATION RESEARCH

Role of cardiolipin peroxidation and Ca2+ in mitochondrial dysfunction and disease

(2009) Giuseppe Paradies et al.   CELL CALCIUM

Intracellular signaling pathways control mitochondrial events associated with the development of ischemia/ reperfusion-associated damage

(2009) Robert Sucher et al.   TRANSPLANT INTERNATIONAL

Superoxide Flashes in Single Mitochondria

(2008) Wang Wang et al.   CELL

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

MG53 nucleates assembly of cell membrane repair machinery

(2008) Chuanxi Cai et al.   NATURE CELL BIOLOGY