SSBP1 drives high fructose-induced glomerular podocyte ferroptosis via activating DNA-PK/p53 pathway

Genotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response

(2021) Ting-Yu Chen et al.   CELL DEATH AND DIFFERENTIATION

Atractylodis rhizoma water extract attenuates fructose-induced glomerular injury in rats through anti-oxidation to inhibit TRPC6/p-CaMK4 signaling

(2021) Li Chen et al.   PHYTOMEDICINE

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pterostilbene protects cochlea from ototoxicity in streptozotocin-induced diabetic rats by inhibiting apoptosis

(2020) Sibel Özdaş et al.   PLoS One

Induction of Autophagy by Pterostilbene Contributes to the Prevention of Renal Fibrosis via Attenuating NLRP3 Inflammasome Activation and Epithelial-Mesenchymal Transition

(2020) Ying-Jan Wang et al.   Frontiers in Cell and Developmental Biology

xCT: A Critical Molecule That Links Cancer Metabolism to Redox Signaling

(2020) Jinyun Liu et al.   MOLECULAR THERAPY

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

(2020) Pranavi Koppula et al.   Protein & Cell

The BRD7-P53-SLC25A28 axis regulates ferroptosis in hepatic stellate cells

(2020) Zili Zhang et al.   Redox Biology

Pterostilbene prevents hepatocyte EMT in fructose-induced liver fibrosis through suppressing miR-34a/Sirt1/p53 and TGF-β1/Smads signaling

(2019) Lin Song et al.   BRITISH JOURNAL OF PHARMACOLOGY

Epigenetic regulation of ferroptosis by H2B monoubiquitination and p53

(2019) Yufei Wang et al.   EMBO REPORTS

Porcine epidemic diarrhea virus infections induce apoptosis in Vero cells via a reactive oxygen species (ROS)/p53, but not p38 MAPK and SAPK/JNK signalling pathways

(2019) Xingang Xu et al.   VETERINARY MICROBIOLOGY

Pterostilbene Activates the Nrf2-Dependent Antioxidant Response to Ameliorate Arsenic-Induced Intracellular Damage and Apoptosis in Human Keratinocytes

(2019) Junfeng Zhou et al.   Frontiers in Pharmacology

SSBP1 mutations in dominant optic atrophy with variable retinal degeneration

(2019) Neringa Jurkute et al.   ANNALS OF NEUROLOGY

Pterostilbene reverses palmitic acid mediated insulin resistance in HepG2 cells by reducing oxidative stress and triglyceride accumulation

(2019) Sajad Ahmad Malik et al.   FREE RADICAL RESEARCH

ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes

(2019) G. Michelle Ducasa et al.   JOURNAL OF CLINICAL INVESTIGATION

From podocyte biology to novel cures for glomerular disease

(2019) Elena Torban et al.   KIDNEY INTERNATIONAL

Magnesium isoglycyrrhizinate ameliorates fructose-induced podocyte apoptosis through downregulation of miR-193a to increase WT1

(2019) Tu-Shuai Li et al.   BIOCHEMICAL PHARMACOLOGY

Mitochondrial single-stranded DNA binding protein novel de novo SSBP1 mutation in a child with single large-scale mtDNA deletion (SLSMD) clinically manifesting as Pearson, Kearns-Sayre, and Leigh syndromes

(2019) Margaret A. Gustafson et al.   PLoS One

Dominant mutations in mtDNA maintenance gene SSBP1 cause optic atrophy and foveopathy

(2019) Camille Piro-Mégy et al.   JOURNAL OF CLINICAL INVESTIGATION

SSBP1 mutations cause mtDNA depletion underlying a complex optic atrophy disorder

(2019) Valentina Del Dotto et al.   JOURNAL OF CLINICAL INVESTIGATION

AT1R-Mediated Apoptosis of Bone Marrow Mesenchymal Stem Cells Is Associated with mtROS Production and mtDNA Reduction

(2019) Fenxi Zhang et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial DNA replication in mammalian cells: overview of the pathway

(2018) Maria Falkenberg   Essays in Biochemistry

Mutant and wild-type p53 form complexes with p73 upon phosphorylation by the kinase JNK

(2018) Eric R. Wolf et al.   Science Signaling

Mutant and wild-type p53 form complexes with p73 upon phosphorylation by the kinase JNK

(2018) Eric R. Wolf et al.   Science Signaling

LONP1 Is Required for Maturation of a Subset of Mitochondrial Proteins, and Its Loss Elicits an Integrated Stress Response

(2018) Olga Zurita Rendón et al.   MOLECULAR AND CELLULAR BIOLOGY

Pterostilbene, a bioactive component of blueberries, alleviates renal fibrosis in a severe mouse model of hyperuricemic nephropathy

(2018) Jing Pan et al.   BIOMEDICINE & PHARMACOTHERAPY

Pterostilbene alleviates fructose-induced renal fibrosis by suppressing TGF-β1/TGF-β type I receptor/Smads signaling in proximal tubular epithelial cells

(2018) Ting-Ting Gu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Single-Stranded DNA-Binding Protein 1 Abrogates Cardiac Fibroblast Proliferation and Collagen Expression Induced by Angiotensin II

(2018) Hai-Ping Tian et al.   International Heart Journal

mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53

(2018) Seung Hee Jung et al.   ONCOGENE

Effects of melatonin on fatty liver disease: The role of NR4A1/DNA-PKcs/p53 pathway, mitochondrial fission, and mitophagy

(2017) Hao Zhou et al.   JOURNAL OF PINEAL RESEARCH

Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding

(2017) Peng Liao et al.   MOLECULAR CELL

Upregulation of the ALDOA/DNA-PK/p53 pathway by dietary restriction suppresses tumor growth

(2017) D Ma et al.   ONCOGENE

BID links ferroptosis to mitochondrial cell death pathways

(2017) Sandra Neitemeier et al.   Redox Biology

CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fructose sensitizes Jurkat cells oxidative stress-induced apoptosis via caspase-dependent and caspase-independent mechanisms

(2016) Viviana Diaz-Aguirre et al.   CELL BIOLOGY INTERNATIONAL

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Human mitochondrial DNA replication machinery and disease

(2016) Matthew J Young et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Dietary (–)-epicatechin mitigates oxidative stress, NO metabolism alterations, and inflammation in renal cortex from fructose-fed rats

(2016) Paula D. Prince et al.   FREE RADICAL BIOLOGY AND MEDICINE

Podocyte injury and its consequences

(2016) Michio Nagata   KIDNEY INTERNATIONAL

Pterostilbene inhibits hepatocellular carcinoma through p53/SOD2/ROS-mediated mitochondrial apoptosis

(2016) Liying Guo et al.   ONCOLOGY REPORTS

Pterostilbene and allopurinol reduce fructose-induced podocyte oxidative stress and inflammation via microRNA-377

(2015) Wei Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

DNA-PKCS binding to p53 on the p21WAF1/CIP1 promoter blocks transcription resulting in cell death

(2015) Richard Hill et al.   Oncotarget

Murine Double Minute-2 Prevents p53-Overactivation-Related Cell Death (Podoptosis) of Podocytes

(2014) D. Thomasova et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Decreased mitochondrial DNA copy number in the hippocampus and peripheral blood during opiate addiction is mediated by autophagy and can be salvaged by melatonin

(2013) Yue-Mei Feng et al.   Autophagy

Dietary sodium restriction prevents kidney damage in high fructose-fed rats

(2013) Carole Oudot et al.   KIDNEY INTERNATIONAL

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Renoprotective and antioxidant effects ofSaururus chinensisBaill in rats fed a high-fructose diet

(2011) Ha-Neul Choi et al.   Nutrition Research and Practice