Elucidation of the anticancer potential and tubulin isotype-specific interactions of β-sitosterol

Structural investigations into the binding mode of a novel noscapine analogue, 9-(4-vinylphenyl) noscapine, with tubulin by biochemical analyses and molecular dynamic simulations

(2016) Tejashree Mahaddalkar et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Potential Pharmacological Resources: Natural Bioactive Compounds from Marine-Derived Fungi

(2016) Liming Jin et al.   Marine Drugs

Exploring the Origin of Differential Binding Affinities of Human Tubulin Isotypes αβII, αβIII and αβIV for DAMA-Colchicine Using Homology Modelling, Molecular Docking and Molecular Dynamics Simulations

(2016) Bajarang Vasant Kumbhar et al.   PLoS One

High levels of class III β-tubulin expression are associated with aggressive tumor features in breast cancer

(2016) PATRICK LEBOK et al.   Oncology Letters

Effects of Eribulin on Microtubule Binding and Dynamic Instability Are Strengthened in the Absence of the βIII Tubulin Isotype

(2015) Leslie Wilson et al.   BIOCHEMISTRY

Mechanism of action of ixabepilone and its interactions with the βIII-tubulin isotype

(2015) Manu Lopus et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Biochemical characterization and molecular dynamic simulation of β-sitosterol as a tubulin-binding anticancer agent

(2015) Tejashree Mahaddalkar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Properties of Organic Liquids when Simulated with Long-Range Lennard-Jones Interactions

(2015) Nina M. Fischer et al.   Journal of Chemical Theory and Computation

Taking aim at a dynamic target: Noscapinoids as microtubule-targeted cancer therapeutics

(2015) Manu Lopus et al.   Pharmacological Reports

Microtubule-targeting agents are clinically successful due to both mitotic and interphase impairment of microtubule function

(2014) Jessica J. Field et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The tubulin code: Molecular components, readout mechanisms, and functions

(2014) Carsten Janke   JOURNAL OF CELL BIOLOGY

Molecular insight of isotypes specific β-tubulin interaction of tubulin heterodimer with noscapinoids

(2014) Seneha Santoshi et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

β-sitosterol induces G1 arrest and causes depolarization of mitochondrial membrane potential in breast carcinoma MDA-MB-231 cells

(2013) Shanthi Sri Vundru et al.   BMC Complementary and Alternative Medicine

Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects

(2013) Sergey Fedorov et al.   Marine Drugs

Mechanism of mitotic arrest induced by dolastatin 15 involves loss of tension across kinetochore pairs

(2013) Manu Lopus   MOLECULAR AND CELLULAR BIOCHEMISTRY

Cooperative Stabilization of Microtubule Dynamics by EB1 and CLIP-170 Involves Displacement of Stably Bound Pi at Microtubule Ends

(2012) Manu Lopus et al.   BIOCHEMISTRY

Magnesium Ion–Water Coordination and Exchange in Biomolecular Simulations

(2012) Olof Allnér et al.   Journal of Chemical Theory and Computation

 II-Tubulin and  III-Tubulin Mediate Sensitivity to Peloruside A and Laulimalide, but not Paclitaxel or Vinblastine, in Human Ovarian Carcinoma Cells

(2011) A. Kanakkanthara et al.   MOLECULAR CANCER THERAPEUTICS

A Molecular and Structural Mechanism for G Protein-mediated Microtubule Destabilization

(2010) Rahul H. Davé et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Cell Migration and Cell Division Correlates with Distinct Effects of Microtubule Inhibiting Drugs

(2010) Hailing Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microtubule-binding agents: a dynamic field of cancer therapeutics

(2010) Charles Dumontet et al.   NATURE REVIEWS DRUG DISCOVERY

Anticancer effects of phytosterols

(2009) T A Woyengo et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Tubulin-Targeted Drug Action: Functional Significance of Class II and Class IVb  -Tubulin in Vinca Alkaloid Sensitivity

(2008) P. P. Gan et al.   CANCER RESEARCH