The Expanding Arsenal of Cytotoxic T Cells

Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes

(2022) Hsin-Fang Chang et al.   Nature Communications

Signal strength controls the rate of polarization within CTLs during killing

(2021) Gordon L. Frazer et al.   JOURNAL OF CELL BIOLOGY

An Updated Model for the Epigenetic Regulation of Effector and Memory CD8+ T Cell Differentiation

(2021) Tianhao Xu et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial translation is required for sustained killing by cytotoxic T cells

(2021) Miriam Lisci et al.   SCIENCE

Supramolecular attack particles are autonomous killing entities released from cytotoxic T cells

(2020) Š. Bálint et al.   SCIENCE

Synaptic secretion from human natural killer cells is diverse and includes supramolecular attack particles

(2020) Ashley R. Ambrose et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The exosomes derived from CAR-T cell efficiently target mesothelin and reduce triple-negative breast cancer growth

(2020) Pengxiang Yang et al.   CELLULAR IMMUNOLOGY

NK cells switch from granzyme B to death receptor–mediated cytotoxicity during serial killing

(2019) Isabel Prager et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T cells

(2019) David G Saliba et al.   eLife

CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity

(2019) Wenyan Fu et al.   Nature Communications

Granulysin: The attractive side of a natural born killer

(2019) E. Sparrow et al.   IMMUNOLOGY LETTERS

Mechanistic peculiarities of activation-induced mobilization of cytotoxic effector proteins in human T cells

(2018) Marcus Lettau et al.   INTERNATIONAL IMMUNOLOGY

Perforin—A key (shaped) weapon in the immunological arsenal

(2017) Bradley A. Spicer et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

CD4 CTL, a Cytotoxic Subset of CD4+ T Cells, Their Differentiation and Function

(2017) Arata Takeuchi et al.   Frontiers in Immunology

IL-12 stimulates CTLs to secrete exosomes capable of activating bystander CD8+ T cells

(2017) Lei Li et al.   Scientific Reports

VAMP8-dependent fusion of recycling endosomes with the plasma membrane facilitates T lymphocyte cytotoxicity

(2015) Misty R. Marshall et al.   JOURNAL OF CELL BIOLOGY

Cutting Edge: Regulation of Exosome Secretion by the Integral MAL Protein in T Cells

(2015) Leandro N. Ventimiglia et al.   JOURNAL OF IMMUNOLOGY

Lysosome-Related Effector Vesicles in T Lymphocytes and NK Cells

(2015) M. Lettau et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Cell Death Signaling

(2015) Douglas R. Green et al.   Cold Spring Harbor Perspectives in Biology

The interface between transcriptional and epigenetic control of effector and memory CD8+T-cell differentiation

(2014) Simon M. Gray et al.   IMMUNOLOGICAL REVIEWS

Real-Time Detection of CTL Function Reveals Distinct Patterns of Caspase Activation Mediated by Fas versus Granzyme B

(2014) Jinzhu Li et al.   JOURNAL OF IMMUNOLOGY

LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity

(2013) K. Krzewski et al.   BLOOD

Lysosome-related organelles: unusual compartments become mainstream

(2013) Michael S Marks et al.   CURRENT OPINION IN CELL BIOLOGY

Syntaxin11 serves as a t-SNARE for the fusion of lytic granules in human cytotoxic T lymphocytes

(2013) Mahantappa Halimani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

An initial and rapid step of lytic granule secretion precedes microtubule organizing center polarization at the cytotoxic T lymphocyte/target cell synapse

(2013) F. Bertrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptobrevin2 is the v-SNARE required for cytotoxic T-lymphocyte lytic granule fusion

(2013) Ulf Matti et al.   Nature Communications

Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death

(2012) Jamie A. Lopez et al.   TRENDS IN IMMUNOLOGY

Diacylglycerol kinase α regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes

(2011) R Alonso et al.   CELL DEATH AND DIFFERENTIATION

Protection from Endogenous Perforin: Glycans and the C Terminus Regulate Exocytic Trafficking in Cytotoxic Lymphocytes

(2011) Amelia J. Brennan et al.   IMMUNITY

Two modes of lytic granule fusion during degranulation by natural killer cells

(2011) Dongfang Liu et al.   IMMUNOLOGY AND CELL BIOLOGY

Effector Granules in Human T Lymphocytes: Proteomic Evidence for Two Distinct Species of Cytotoxic Effector Vesicles

(2011) Hendrik Schmidt et al.   JOURNAL OF PROTEOME RESEARCH

Familial Hemophagocytic Lymphohistiocytosis Type 5 (FHL-5) Is Caused by Mutations in Munc18-2 and Impaired Binding to Syntaxin 11

(2009) Udo zur Stadt et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Stored Fas Ligand, a Mediator of Rapid CTL-Mediated Killing, Has a Lower Threshold for Response Than Degranulation or Newly Synthesized Fas Ligand

(2009) J.-S. He et al.   JOURNAL OF IMMUNOLOGY

Death by a Thousand Cuts: Granzyme Pathways of Programmed Cell Death

(2008) Dipanjan Chowdhury et al.   Annual Review of Immunology

A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion

(2008) G. Menasche et al.   BLOOD

ESCRT complexes and the biogenesis of multivesicular bodies

(2008) James H Hurley   CURRENT OPINION IN CELL BIOLOGY

Visualizing CTL/melanoma cell interactions: multiple hits must be delivered for tumour cell annihilation

(2008) Íris Caramalho et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Slp1 and Slp2-a Localize to the Plasma Membrane of CTL and Contribute to Secretion from the Immunological Synapse

(2008) Oliver Holt et al.   TRAFFIC