Anti‐Oxidative and Anti‐Inflammatory Micelles: Break the Dry Eye Vicious Cycle

Optimizing an Antioxidant TEMPO Copolymer for Reactive Oxygen Species Scavenging and Anti-Inflammatory Effects in Vivo

(2021) Carlisle R. DeJulius et al.   BIOCONJUGATE CHEMISTRY

Antimicrobial nanomedicine for ocular bacterial and fungal infection

(2021) Wenjie Fan et al.   Drug Delivery and Translational Research

A bioinspired synthetic soft hydrogel for the treatment of dry eye

(2021) Yu Yu et al.   Bioengineering & Translational Medicine

Effectiveness of an ocular adhesive polyhedral oligomeric silsesquioxane hybrid thermo-responsive FK506 hydrogel in a murine model of dry eye

(2021) Yi Han et al.   Bioactive Materials

Systemic antiviral immunization by virus-mimicking nanoparticles-decorated erythrocytes

(2021) Lu Wang et al.   Nano Today

An oral pH-activated “nano-bomb” carrier combined with berberine by regulating gene silencing and gut microbiota for site-specific treatment of ulcerative colitis

(2021) Mei Yang et al.   Biomaterials Science

A Novel Selective 11β-HSD1 Inhibitor, (E)-4-(2-(6-(2,6-Dichloro-4-(Trifluoromethyl)Phenyl)-4-Methyl-1,1-Dioxido-1,2,6-Thiadiazinan-2-yl)Acetamido)Adamantan-1-Carboxamide (KR-67607), Prevents BAC-Induced Dry Eye Syndrome

(2020) Yoon-Ju Na et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Co-delivery of p38α MAPK and p65 siRNA by novel liposomal glomerulus-targeting nano carriers for effective immunoglobulin a nephropathy treatment

(2020) Yuanfang Wang et al.   JOURNAL OF CONTROLLED RELEASE

Nanoscale poly(acrylic acid)-based hydrogels prepared via a green single-step approach for application as low-viscosity biomimetic fluid tears

(2020) Ahmed E. Swilem et al.   Materials Science & Engineering C-Materials for Biological Applications

RNAi Screening Identifies that TEX10 Promotes the Proliferation of Colorectal Cancer Cells by Increasing NF‐ κ B Activation

(2020) Ziyang Wang et al.   Advanced Science

Lipidomic analysis of epithelial corneal cells following hyperosmolarity and benzalkonium chloride exposure: New insights in dry eye disease

(2020) Romain Magny et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Inflammatory basis for dry eye disease flares

(2020) Victor L. Perez et al.   EXPERIMENTAL EYE RESEARCH

Long-acting mucoadhesive thermogels for improving topical treatments of dry eye disease

(2020) Li-Jyuan Luo et al.   Materials Science & Engineering C-Materials for Biological Applications

A Clinical Phase II Study to Assess Efficacy, Safety, and Tolerability of CyclASol for Treatment of Dry Eye Disease

(2019) David L. Wirta et al.   OPHTHALMOLOGY

Losmapimod Protected Epileptic Rats From Hippocampal Neuron Damage Through Inhibition of the MAPK Pathway

(2019) Min Li et al.   Frontiers in Pharmacology

Phenylboronic acid-tethered chondroitin sulfate-based mucoadhesive nanostructured lipid carriers for the treatment of dry eye syndrome

(2019) Guoxin Tan et al.   Acta Biomaterialia

A Proresolving Peptide Nanotherapy for Site‐Specific Treatment of Inflammatory Bowel Disease by Regulating Proinflammatory Microenvironment and Gut Microbiota

(2019) Chenwen Li et al.   Advanced Science

A cerium oxide loaded glycol chitosan nano-system for the treatment of dry eye disease

(2019) Fan Yu et al.   JOURNAL OF CONTROLLED RELEASE

Self-assembled, biocompatible and biodegradable TEMPO-conjugated nanoparticles enable folate-targeted tumor magnetic resonance imaging

(2019) Ozioma Udochukwu Akakuru et al.   Applied Materials Today

Ocular delivery of proteins and peptides: Challenges and novel formulation approaches

(2018) Abhirup Mandal et al.   ADVANCED DRUG DELIVERY REVIEWS

Reactive oxygen species scavenging with a biodegradable, thermally responsive hydrogel compatible with soft tissue injection

(2018) Yang Zhu et al.   BIOMATERIALS

Nitroxide radical-containing nanoparticles attenuate tumorigenic potential of triple negative breast cancer

(2018) Babita Shashni et al.   BIOMATERIALS

Amino-Functionalized Mesoporous Silica Particles for Ocular Delivery of Brimonidine

(2018) Se-Na Kim et al.   MOLECULAR PHARMACEUTICS

Dry Eye

(2018) Janine A. Clayton   NEW ENGLAND JOURNAL OF MEDICINE

p-Coumaric Acid Protects Human Lens Epithelial Cells against Oxidative Stress-Induced Apoptosis by MAPK Signaling

(2018) Jiao Peng et al.   Oxidative Medicine and Cellular Longevity

The Eye, Oxidative Damage and Polyunsaturated Fatty Acids

(2018) Sergio Saccà et al.   Nutrients

Targeted Therapy of Atherosclerosis by a Broad-Spectrum Reactive Oxygen Species Scavenging Nanoparticle with Intrinsic Anti-inflammatory Activity

(2018) Yuquan Wang et al.   ACS Nano

Calcitriol inhibits ROS-NLRP3-IL-1β signaling axis via activation of Nrf2-antioxidant signaling in hyperosmotic stress stimulated human corneal epithelial cells

(2018) Yiqin Dai et al.   Redox Biology

A Comparison of the Effects of Benzalkonium Chloride on Ocular Surfaces between C57BL/6 and BALB/c Mice

(2017) Qian Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inflammation in Dry Eye Disease

(2017) Michelle K. Rhee et al.   OPHTHALMOLOGY

The Pathophysiology of Dry Eye Disease

(2017) Stephen C. Pflugfelder et al.   OPHTHALMOLOGY

Modern approaches to the ocular delivery of cyclosporine A

(2016) Priyanka Agarwal et al.   DRUG DISCOVERY TODAY

Theranostic reduction-sensitive gemcitabine prodrug micelles for near-infrared imaging and pancreatic cancer therapy

(2016) Haijie Han et al.   Nanoscale

Rapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A

(2016) Chong Xu et al.   NEUROPHARMACOLOGY

The Matrix Metalloproteinase 9 Point-of-Care Test in Dry Eye

(2016) Nicole L. Lanza et al.   Ocular Surface

Goblet cells of the conjunctiva: A review of recent findings

(2016) Ilene K. Gipson   PROGRESS IN RETINAL AND EYE RESEARCH

PACAP suppresses dry eye signs by stimulating tear secretion

(2016) Tomoya Nakamachi et al.   Nature Communications

Macrophage Phenotype in the Ocular Surface of Experimental Murine Dry Eye Disease

(2015) In-Cheon You et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial

(2014) L Kristin Newby et al.   LANCET

Spdef Null Mice Lack Conjunctival Goblet Cells and Provide a Model of Dry Eye

(2013) Christina K. Marko et al.   AMERICAN JOURNAL OF PATHOLOGY

Efficacy and safety of the p38 MAPK inhibitor losmapimod for patients with chronic obstructive pulmonary disease: a randomised, double-blind, placebo-controlled trial

(2013) Henrik Watz et al.   Lancet Respiratory Medicine

Nuclear Factor-κB: Central Regulator in Ocular Surface Inflammation and Diseases

(2012) Wanwen Lan et al.   Ocular Surface

Reduction of oxidative stress by p-hydroxybenzyl alcohol-containing biodegradable polyoxalate nanoparticulate antioxidant

(2011) Soojin Kim et al.   BIOMATERIALS

Synthesis and property of poly(sodium 4-styrenesulfonate) grafted chitosan by nitroxide-mediated polymerization with chitosan-TEMPO macroinitiator

(2010) Jianlin Jiang et al.   CARBOHYDRATE POLYMERS

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

(2010) Anna E. Dikalova et al.   CIRCULATION RESEARCH

Preservatives in eyedrops: The good, the bad and the ugly

(2010) Christophe Baudouin et al.   PROGRESS IN RETINAL AND EYE RESEARCH

p38MAPK: stress responses from molecular mechanisms to therapeutics

(2009) Lydia R. Coulthard et al.   TRENDS IN MOLECULAR MEDICINE