Crystal structure of the ternary complex of Leishmania major pteridine reductase 1 with the cofactor NADP+/NADPH and the substrate folic acid
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Title
Crystal structure of the ternary complex of Leishmania major pteridine reductase 1 with the cofactor NADP+/NADPH and the substrate folic acid
Authors
Keywords
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Journal
Acta Crystallographica Section F-Structural Biology Communications
Volume 78, Issue 4, Pages 170-176
Publisher
International Union of Crystallography (IUCr)
Online
2022-03-30
DOI
10.1107/s2053230x22002795
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Note: Only part of the references are listed.- Enhancement of benzothiazoles as Pteridine Reductase-1 (PTR1) inhibitors for the treatment of Trypanosomatidic infections.
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- Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega
- (2011) F. Sievers et al. Molecular Systems Biology
- High-resolution structures ofTrypanosoma bruceipteridine reductase ligand complexes inform on the placement of new molecular entities in the active site of a potential drug target
- (2010) Alice Dawson et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
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- MolProbity: all-atom structure validation for macromolecular crystallography
- (2009) Vincent B. Chen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Structure-Based Design of Pteridine Reductase Inhibitors Targeting African Sleeping Sickness and the Leishmaniases
- (2009) Lindsay B. Tulloch et al. JOURNAL OF MEDICINAL CHEMISTRY
- Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7
- (2008) Gerrit Langer et al. Nature Protocols
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