Journal
NANOMATERIALS
Volume 12, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/nano12081310
Keywords
tannic acid; magnetic nanoparticles; antioxidant activity; cellular uptake
Categories
Funding
- Czech Science Foundation [20-02177J]
- Ministry of Science and Technology of the Republic of China [MOST 109-2923-B-182-001-MY3]
- Chang Gung Memorial Hospital [BMRP432]
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In this study, tannic acid-modified silica magnetic nanoparticles were developed for antioxidant and cellular internalization purposes. The results showed that the tannic acid-modified particles exhibited high antioxidant activity and were well-internalized by LN-229 cells when a double layer of tannic acid-coating was applied. Additionally, the presence of a magnet greatly increased the cellular uptake of all tannic acid-coated magnetic nanoparticles. The coating had a significant impact on nanoparticle-cell interactions and particle internalization. These tannic acid-coated magnetic nanoparticles have great potential as intracellular carriers with preserved antioxidant activity.
Coating of nanoparticles with gallates renders them antioxidant and enhances cellular internalization. In this study, (amino)silica magnetic particles modified with tannic acid (TA) and optionally with chitosan (CS) were developed, and their physicochemical properties and antioxidant activity were evaluated. The results demonstrated that the TA-modified aminosilica-coated particles, as well as the silica-coated particles with a double TA layer, exhibited high antioxidant activity, whereas the silica-coated particles with no or only a single TA layer were well-internalized by LN-229 cells. In addition, a magnet placed under the culture plates greatly increased the cellular uptake of all TA-coated magnetic nanoparticles. The coating thus had a considerable impact on nanoparticle-cell interactions and particle internalization. The TA-coated magnetic nanoparticles have great potential as intracellular carriers with preserved antioxidant activity.
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