High expression of uracil DNA glycosylase determines C to T substitution in human pluripotent stem cells

Universal toxin-based selection for precise genome engineering in human cells

(2021) Songyuan Li et al.   Nature Communications

Base editing-mediated splicing correction therapy for spinal muscular atrophy

(2020) Xiang Lin et al.   CELL RESEARCH

Glycosylase base editors enable C-to-A and C-to-G base changes

(2020) Dongdong Zhao et al.   NATURE BIOTECHNOLOGY

Cas12a Base Editors Induce Efficient and Specific Editing with Low DNA Damage Response

(2020) Xiao Wang et al.   Cell Reports

Features of DNA Repair in the Early Stages of Mammalian Embryonic Development

(2020) Evgenia V. Khokhlova et al.   Genes

Safe scarless cassette-free selection of genome-edited human pluripotent stem cells using temporary drug resistance

(2020) Keun-Tae Kim et al.   BIOMATERIALS

DNA repair fidelity in stem cell maintenance, health, and disease

(2019) Chinnadurai Mani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Highly Efficient and Marker-free Genome Editing of Human Pluripotent Stem Cells by CRISPR-Cas9 RNP and AAV6 Donor-Mediated Homologous Recombination

(2019) Renata M. Martin et al.   Cell Stem Cell

Base editor correction of COL7A1 in recessive dystrophic epidermolysis bullosa patient-derived fibroblasts and iPSCs

(2019) Mark J. Osborn et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction

(2018) Luke W Koblan et al.   NATURE BIOTECHNOLOGY

p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells

(2018) Robert J. Ihry et al.   NATURE MEDICINE

Efficient base editing in methylated regions with a human APOBEC3A-Cas9 fusion

(2018) Xiao Wang et al.   NATURE BIOTECHNOLOGY

Highly efficient genome editing via CRISPR–Cas9 in human pluripotent stem cells is achieved by transient BCL-XL overexpression

(2018) Xiao-Lan Li et al.   NUCLEIC ACIDS RESEARCH

Base editing: precision chemistry on the genome and transcriptome of living cells

(2018) Holly A. Rees et al.   NATURE REVIEWS GENETICS

Intact wound repair activity of human mesenchymal stem cells after YM155 mediated selective ablation of undifferentiated human embryonic stem cells

(2017) Keun-Tae Kim et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

(2017) Nicole M. Gaudelli et al.   NATURE

Induced Pluripotent Stem Cells Meet Genome Editing

(2016) Dirk Hockemeyer et al.   Cell Stem Cell

DNA repair mechanisms in embryonic stem cells

(2016) Xuemei Fu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

(2016) Alexis C. Komor et al.   NATURE

From Genomics to Gene Therapy: Induced Pluripotent Stem Cells Meet Genome Editing

(2015) Akitsu Hotta et al.   Annual Review of Genetics

A Porous Membrane-Mediated Isolation of Mesenchymal Stem Cells from Human Embryonic Stem Cells

(2015) Ki-Sung Hong et al.   TISSUE ENGINEERING PART C-METHODS

Genome maintenance in pluripotent stem cells

(2014) Uri Weissbein et al.   JOURNAL OF CELL BIOLOGY

High Mitochondrial Priming Sensitizes hESCs to DNA-Damage-Induced Apoptosis

(2013) Julia C. Liu et al.   Cell Stem Cell

Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases

(2013) S. W. Cho et al.   GENOME RESEARCH

Inhibition of pluripotent stem cell-derived teratoma formation by small molecules

(2013) M.-O. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Base Excision Repair

(2013) H. E. Krokan et al.   Cold Spring Harbor Perspectives in Biology

AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation

(2012) Christopher S Nabel et al.   Nature Chemical Biology

Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA

(2012) Solange Moréra et al.   NUCLEIC ACIDS RESEARCH

Thymine DNA Glycosylase Is Essential for Active DNA Demethylation by Linked Deamination-Base Excision Repair

(2011) Salvatore Cortellino et al.   CELL

Mismatch and base excision repair proficiency in murine embryonic stem cells

(2011) Elisia D. Tichy et al.   DNA REPAIR

Regulation of the Wip1 phosphatase and its effects on the stress response Julie Lowe, Hyukjin Cha, Mi-Ok Lee, Sharlyn J. Mazur, Ettore Appella, Albert J. Fornace Jr.

(2011) Julie Lowe   Frontiers in Bioscience-Landmark

Diseases in a dish: modeling human genetic disorders using induced pluripotent cells

(2011) Gustavo Tiscornia et al.   NATURE MEDICINE

Wip1 Directly Dephosphorylates  -H2AX and Attenuates the DNA Damage Response

(2010) H. Cha et al.   CANCER RESEARCH

Mouse Embryonic Stem Cells, but Not Somatic Cells, Predominantly Use Homologous Recombination to Repair Double-Strand DNA Breaks

(2010) Elisia D. Tichy et al.   STEM CELLS AND DEVELOPMENT