Alternative Splicing and Isoforms: From Mechanisms to Diseases

The role of alternative splicing in cancer: From oncogenesis to drug resistance

(2020) Rocco Sciarrillo et al.   DRUG RESISTANCE UPDATES

TDP-43 and NOVA-1 RNA-binding proteins as competitive splicing regulators of the schizophrenia-associated TNIK gene

(2019) Valentina Gumina et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models

(2019) Betty Y. Tam et al.   CANCER LETTERS

Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

(2019) Shatha AbuHammad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative splicing in aging and longevity

(2019) Malini Bhadra et al.   HUMAN GENETICS

Alternative Splicing as a Target for Cancer Treatment

(2018) Nancy Martinez-Montiel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alternative mRNA Splicing in the Pathogenesis of Obesity

(2018) Chi-Ming Wong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alternative splicing isoforms in health and disease

(2018) Hyoung Kyu Kim et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Targeting the spliceosome for cutaneous squamous cell carcinoma therapy: a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity

(2018) Lydia A. Hepburn et al.   Oncotarget

Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing

(2018) Sarah V. Gerhart et al.   Scientific Reports

Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics

(2018) Laura M. Urbanski et al.   Wiley Interdisciplinary Reviews-RNA

Selective induction of alternatively spliced FynT isoform by TNF facilitates persistent inflammatory responses in astrocytes

(2017) Chingli Lee et al.   Scientific Reports

The Role of Insulin Receptor Isoforms in Diabetes and Its Metabolic and Vascular Complications

(2017) O. Escribano et al.   Journal of Diabetes Research

Faulty splicing and cytoskeleton abnormalities in Huntington's disease

(2016) Marta Fernández-Nogales et al.   BRAIN PATHOLOGY

microRNAs target SRSF7 splicing factor to modulate the expression of osteopontin splice variants in renal cancer cells

(2016) Joanna Boguslawska et al.   GENE

Alternative splicing of S6K1 promotes non-small cell lung cancer survival

(2016) Hong Mei et al.   TUMOR BIOLOGY

Akt-dependent activation of Erk by cyclin D1b contributes to cell invasiveness and tumorigenicity

(2016) Chul Jang Kim et al.   Oncology Letters

GeneBase 1.1: a tool to summarize data from NCBI gene datasets and its application to an update of human gene statistics

(2016) Allison Piovesan et al.   Database-The Journal of Biological Databases and Curation

Alternative splicing as a biomarker and potential target for drug discovery

(2015) Kai-qin Le et al.   ACTA PHARMACOLOGICA SINICA

SnapShot: Spliceosome Dynamics I

(2015) Markus C. Wahl et al.   CELL

Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B

(2015) M. K. Kashyap et al.   HAEMATOLOGICA

Antisense oligonucleotide–mediated MDM4 exon 6 skipping impairs tumor growth

(2015) Michael Dewaele et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B

(2015) M. K. Kashyap et al.   HAEMATOLOGICA

Cyclin D1b splice variant promotes αvβ3-mediated adhesion and invasive migration of breast cancer cells

(2014) Feng-Hua Wu et al.   CANCER LETTERS

Splicing factor SRSF6 promotes hyperplasia of sensitized skin

(2014) Mads A Jensen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sudemycin E influences alternative splicing and changes chromatin modifications

(2014) Paolo Convertini et al.   NUCLEIC ACIDS RESEARCH

SnapShot-Seq: A Method for Extracting Genome-Wide, In Vivo mRNA Dynamics from a Single Total RNA Sample

(2014) Jesse M. Gray et al.   PLoS One

Regulation of splicing by SR proteins and SR protein-specific kinases

(2013) Zhihong Zhou et al.   CHROMOSOMA

Alternative splicing and retinal degeneration

(2013) M M Liu et al.   CLINICAL GENETICS

Adipose tissue INSR splicing in humans associates with fasting insulin level and is regulated by weight loss

(2013) Dorota Kaminska et al.   DIABETOLOGIA

Alternative splicing of AMPA receptor subunits in the 6-OHDA-lesioned rat model of Parkinson's disease and L-DOPA-induced dyskinesia

(2013) Christopher Kobylecki et al.   EXPERIMENTAL NEUROLOGY

Alternative transcription and alternative splicing in cancer

(2012) Sharmistha Pal et al.   PHARMACOLOGY & THERAPEUTICS

S6K1 Alternative Splicing Modulates Its Oncogenic Activity and Regulates mTORC1

(2012) Vered Ben-Hur et al.   Cell Reports

Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A

(2011) A. Corrionero et al.   GENES & DEVELOPMENT

SRRM2, a Potential Blood Biomarker Revealing High Alternative Splicing in Parkinson's Disease

(2010) Lina A. Shehadeh et al.   PLoS One

Disturbed Expression of Splicing Factors in Renal Cancer Affects Alternative Splicing of Apoptosis Regulators, Oncogenes, and Tumor Suppressors

(2010) Agnieszka Piekielko-Witkowska et al.   PLoS One

Cyclin D1b variant promotes cell invasiveness independent of binding to CDK4 in human bladder cancer cells

(2009) Chul Jang Kim et al.   MOLECULAR CARCINOGENESIS

Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

(2009) Mo Chen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cyclin D1b protein expression in breast cancer is independent of cyclin D1a and associated with poor disease outcome

(2009) E K A Millar et al.   ONCOGENE

SRp20 and CUG-BP1 Modulate Insulin Receptor Exon 11 Alternative Splicing

(2008) S. Sen et al.   MOLECULAR AND CELLULAR BIOLOGY