Journal
JOURNAL OF BIOMECHANICS
Volume 49, Issue 8, Pages 1347-1354Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2015.10.014
Keywords
Cell mechanics; Cytoskeleton; Mechanobiology; Tissue engineering
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Funding
- National Science Foundation [CBET-0854129, IDBR-1455671]
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Cells in various tissues are subjected to mechanical stress and strain that have profound effects on cell architecture and function. The specific response of the cell to applied strain depends on multiple factors, including cell contractility, spatial and temporal strain pattern, and substrate dimensionality and rigidity. Recent work has demonstrated that the cell response to applied strain depends on a complex combination of these factors, but the way these factors interact to elicit a specific response is not intuitive. We submit that an understanding of the integrated response of a cell to these factors will provide new insight into mechanobiology and contribute to the effective design of deformable engineered scaffolds meant to provide appropriate mechanical cues to the resident cells. (C) 2015 Elsevier Ltd. All rights reserved.
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