Article
Biochemistry & Molecular Biology
Keng-Yu Chiang, Ya-Wen Li, Yen-Hsing Li, Shin-Jie Huang, Chih-Lu Wu, Hong-Yi Gong, Jen-Leih Wu
Summary: The study suggests that progranulin A (GrnA) plays a positive regulatory role in liver regeneration process by promoting hepatocyte proliferation, possibly through enhancing HGF/c-met signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Miao Wang, Chuan Lin, Xiaodong Jia, Di Fang, Qinhua Gao, Chunmei Han
Summary: The complete regeneration of deer antlers relies on stem cells proliferation and differentiation. Mesenchymal stem cells of antlers play a crucial role in this process. HGF, synthesized and secreted by mesenchymal cells, binds to c-Met receptor to stimulate cell proliferation and migration, promoting tissue morphogenesis and angiogenesis. However, the role and mechanism of HGF/c-Met signaling pathway on antler MSCs are still unclear.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Mahdia Benkhoucha, Ngoc Lan Tran, Gautier Breville, Isis Senoner, Paul F. Bradfield, Thalia Papayannopoulou, Doron Merkler, Thomas Korn, Patrice H. Lalive
Summary: CD4(+)c-Met(+) T cells are increased in multiple sclerosis models and exhibit a pro-inflammatory phenotype with enhanced adhesion and migration.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Medical Laboratory Technology
Xin Yang, Hai-Yang Liao, Hai-Hong Zhang
Summary: The MET gene plays a significant role in the initiation and development of various human cancers, affecting cell proliferation, migration, and invasion. MET serves as a biomarker for diagnosis and prognosis, and is also a potential therapeutic target. Inhibiting MET expression and function may have clinical benefits in cancer treatment.
CLINICA CHIMICA ACTA
(2022)
Article
Oncology
Patricia Dias Carvalho, Flavia Martins, Susana Mendonca, Andreia Ribeiro, Ana Luisa Machado, Joana Carvalho, Maria Jose Oliveira, Sergia Velho
Summary: This study reveals the role of mutant KRAS in modulating cell fate through autonomous and nonautonomous signaling mechanisms in colorectal cancer cells. Mutant KRAS autonomously controls processes such as proliferation and cell-cell aggregation, while cancer cell invasion depends on the cooperation between fibroblast-derived HGF and mutant KRAS regulation of C-MET expression.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Oncology
Fatemeh Moosavi, Elisa Giovannetti, Godefridus J. Peters, Omidreza Firuzi
Summary: MET receptor is a promising therapeutic target in various human cancers, with HGF/MET combination therapies showing potential in overcoming drug resistance, targeting tumor microenvironment, and modulating drug metabolism. Further research is needed to fully understand the molecular mechanisms underlying successful pharmacological combinations.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Oncology
Xi Dong, Yun Luo, Shan Lu, Han Ma, Wenchao Zhang, Yue Zhu, Guibo Sun, Xiaobo Sun
Summary: This study demonstrates that ursodesoxycholic acid (UDCA) can alleviate liver fibrosis by promoting liver regeneration through activation of the ID1-WNT2/hepatocyte growth factor (HGF) pathway. Additionally, it was found that Id1 plays a crucial role in the protective effects of UDCA against liver fibrosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Rishav Sharma, Rishabha Malviya
Summary: Pancreatic cancer is highly lethal and difficult to treat, with hypoxia promoting its development and spread. The interaction between cancer cells, stromal cells, and pancreatic stellate cells mediated by the HGF/c-MET pathway plays a crucial role in disease progression. Hypoxia and HGF/c-MET expression are important factors in pancreatic cancer treatment.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Oncology
Jacquelyn T. T. Saunders, Sunil Kumar, Angelica Benavides-Serrato, Brent Holmes, Kennedy E. E. Benavides, Muhammad T. T. Bashir, Robert N. N. Nishimura, Joseph Gera
Summary: A circular RNA encoded HGF protein variant, C-HGF, was discovered to activate c-MET and promote glioblastoma growth and invasion. Inhibition of C-HGF may provide a promising approach for glioblastoma treatment.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Oncology
Chiara Modica, Marco Cortese, Francesca Bersani, Andrea Maria Lombardi, Francesca Napoli, Luisella Righi, Riccardo Taulli, Cristina Basilico, Elisa Vigna
Summary: The MET receptor and its ligand Hepatocyte Growth Factor (HGF) play important roles in cell proliferation, survival, motility, and invasion. The HGF/MET axis regulates both cell-autonomous and non-cell-autonomous functions in cancer cell dissemination. Knocking out the MET gene in cancer cells allowed for the evaluation of the role of the HGF/MET axis in cell-autonomous functions independently of its effect on tumor microenvironment cells. The results suggest a crucial contribution of the HGF/MET axis in driving the metastatic process.
Article
Oncology
Yi Xiang, Bishan Liang, Yu Jiang, Fei Sun, Yang Zhao, Qijing Wu, Xingbin Hu, Yajing Liu, Qiong Huang, Wangjun Liao, Zhiqi Yao, Shaowei Li, Min Shi
Summary: This study identified MACC1 and SPINT1 as key transcription factors with downstream regulatory proteins for predicting patient prognosis in various cancers. The combination of MACC1 and SPINT1 was found to be effective in predicting survival in different cancer types, making it a valuable signature for prognosis prediction.
Article
Oncology
Chiara Modica, Martina Olivero, Francesca Zuppini, Melissa Milan, Cristina Basilico, Elisa Vigna
Summary: This study explores the molecular mechanisms of the MET/HGF signaling pathway in the interaction between pancreatic cancer cells and the tumor microenvironment. Through large-scale gene expression analysis, tenascin C was identified as a key gene involved in sustaining the malignant phenotype. Further research demonstrates the modulation of tenascin C by MET activation, suggesting a role in tumor-stroma interplay during pancreatic tumor progression.
Article
Biology
Debjani Pal, Kuntal De, Carly M. Shanks, Kai Feng, Timothy B. Yates, Jennifer Morrell-Falvey, Russell B. Davidson, Jerry M. Parks, Wellington Muchero
Summary: It was found that the core cysteine residues in the PAN domain of HGF play a crucial role in regulating the c-MET pathway. Mutations in these residues lead to abnormalities in signal transduction and impaired transcriptional activity of cancer-related genes. Targeting the PAN domain of HGF can selectively regulate the c-MET pathway, which is significant for cancer treatment.
COMMUNICATIONS BIOLOGY
(2022)
Review
Cell Biology
Yifan Du, Huimin Sun, Zhiyuan Shi, Xiuyuan Sui, Bin Liu, Zeyuan Zheng, Yankuo Liu, Zuodong Xuan, Min Zhong, Meiling Fu, Yang Bai, Qian Zhang, Chen Shao
Summary: The mutation of MET and the Hedgehog (Hh) pathway both have significant roles in cancer development and tumor stem cell maintenance. Conventional drugs only show moderate efficacy in specific types of cancer, and solely targeting tumor stem cells may overlook the potential for other tumor cells to regain stemness and acquire drug resistance.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Multidisciplinary Sciences
Nayeon Lee, Sunyoung Kim, Junghun Lee
Summary: This study found that nerve regeneration capacity decreases and functional recovery is impaired in the aging PNS. The HGF/c-Met pathway may play a role in the age-related impairment of regenerative capacity.
Article
Endocrinology & Metabolism
Yan-Dong Wang, Wei-Dong Chen, Cunbao Li, Cong Guo, Yanyan Li, Hui Qi, Hailing Shen, Jing Kong, Xuecheng Long, Frank Yuan, Xichun Wang, Wendong Huang
MOLECULAR ENDOCRINOLOGY
(2015)
Article
Oncology
Cong Guo, Jia Su, Zhijun Li, Rui Xiao, Jianxun Wen, Yanyan Li, Meng Zhang, Xueting Zhang, Donna Yu, Wendong Huang, Wei-Dong Chen, Yan-Dong Wang
Review
Physiology
Cong Guo, Wei-Dong Chen, Yan-Dong Wang
FRONTIERS IN PHYSIOLOGY
(2016)
Article
Oncology
Jia Su, Qiqi Zhang, Hui Qi, Linlin Wu, Yuanqiang Li, Donna Yu, Wendong Huang, Wei-Dong Chen, Yan-Dong Wang
Review
Microbiology
Qingqing Feng, Wei-Dong Chen, Yan-Dong Wang
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Shizhen Zhao, Xinping Li, Le Wang, Wenjing Peng, Wenling Ye, Weiguo Li, Yan-Dong Wang, Wei-Dong Chen
Summary: The novel 1-benzyl-1H-imidazole-5-carboxamide derivatives 19d and 19e exhibited potent agonistic activities against hTGR5 and significant glucose-lowering effects in vivo, suggesting them as promising candidates for the treatment of diabetes and obesity.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Qingqing Feng, Hongli Zhang, Denglin Yao, Xiantong Zhang, Wei-Dong Chen, Yan-Dong Wang
Summary: Activation of FXR inhibits proliferation and migration of esophageal squamous cell carcinoma, induces apoptosis and cell cycle arrest, and suppresses inflammatory genes while promoting pro-apoptotic genes. Activation of FXR also decreases phosphorylation levels of ERK1/2 induced by TNF-alpha, leading to suppression of ESCC tumorigenesis both in vitro and in vivo. These findings suggest that targeting FXR may be a promising therapeutic approach for ESCC.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Pathology
Xiaobo Nie, Haisheng Wang, Xiaoyun Wei, Lanqing Li, Ting Xue, Lili Fan, Han Ma, Yubing Xia, Yan-Dong Wang, Wei-Dong Chen
Summary: LRP5 is overexpressed in gastric cancer tissues and its expression is positively associated with advanced clinical stages and poor prognosis. Overexpression of LRP5 enhances proliferation, invasiveness, and drug resistance of gastric cancer cells through activating the canonical Wnt/β-catenin pathway and upregulating glycolysis. LRP5 and glycolysis-related genes also show a positive correlation in gastric cancer tissues.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Cell Biology
Xiaobo Nie, Huiyang Liu, Wenling Ye, Xiaoyun Wei, Lili Fan, Han Ma, Lanqing Li, Wanting Xue, Wenting Qi, Yan-Dong Wang, Wei-Dong Chen
Summary: The activation of low-density lipoprotein receptor-related protein 5 (LRP5) promotes cancer stem cell-like phenotypes in colorectal cancer (CRC) cells through activating the canonical Wnt/beta-catenin and IL-6/STAT3 signaling pathways. The upregulation of LRP5 expression is closely associated with clinical stages of CRC patients. Silencing LRP5 gene can suppress the cancer stem cell-like phenotypes of CRC.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Zixuan Wang, Wei-Dong Chen, Yan-Dong Wang
Summary: Nuclear receptors play crucial roles in the crosstalk between the gut microbiome and the host, regulating metabolic processes, immune activity, and impacting various physiological and pathological conditions. These nuclear receptors may serve as effective targets for treating different diseases.
MOLECULAR MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Shizhen Zhao, Le Wang, Jie Wang, Chenwei Wang, Shaowei Zheng, Yajie Fu, Yunfu Li, Wei-Dong Chen, Ruifang Hou, Dongbin Yang, Yan-Dong Wang
Summary: TGR5 is an important target for the treatment of non-alcoholic steatohepatitis, type 2 diabetes mellitus, and obesity. Novel compounds have been discovered with excellent agonist activity.
Editorial Material
Medicine, General & Internal
Abbas Yadegar, Ali Nabavi-Rad, Javier Ochoa-Reparaz, Toshifumi Ohkusa, Yan-Dong Wang
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Xiao-Bo Nie, Bao-Sheng Shi, Lin Zhang, Wei-Li Niu, Ting Xue, Lan-Qing Li, Xiao-Yun Wei, Yan-Dong Wang, Wei-Dong Chen, Rui-Fang Hou
Summary: This study characterizes the epidemiological features and dynamic changes in blood biochemical indices for SARS-CoV-2-infected patients in Hebi, a representative city in North China. The study identifies potential diagnostic markers and dynamic biochemical indices that can aid in the prevention, diagnosis, and treatment of COVID-19 infection.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Review
Cell Biology
Chao Zhang, Zixuan Wang, Qingqing Feng, Wei-Dong Chen, Yan-Dong Wang
HISTOLOGY AND HISTOPATHOLOGY
(2020)