Article
Pharmacology & Pharmacy
Xiaodong Huang, Wei He, Weiheng Wang, Quanchun Fan, Xiaojian Ye, Zenghui Wu, Chia-Ying Lin
Summary: The study examined the pharmacokinetics and toxicology of simvastatin in whole organs and tissues after intradiscal injection in rabbits. It found that high doses of simvastatin may cause damage to intervertebral disc tissue, with no toxic effects observed at lower doses.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Rizwan Arshad, Hendrik Schmidt, Marwan El-Rich, Kodjo Moglo
Summary: Musculoskeletal disorders of the cervical spine have increased in recent years. This study aimed to develop a dynamic model of the cervical spine and estimate the differences in disc loads, translations, intradiscal pressure, and muscle force/activity in a neutral posture. The results could help distinguish between normal and pathological cervical spine conditions.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Medicine, General & Internal
Christos Gogos, Dimitrios K. Filippiadis, Georgios Velonakis, Nikolaos Kelekis, Panayiotis Papagelopoulos, Alexis Kelekis
Summary: The purpose of this study was to compare the efficacy and safety between intradiscal injection of a gelified ethanol product and tubular discectomy in the treatment of intervertebral disk herniation. The results showed that both treatments were equally effective and safe in improving leg pain over a 12-month period.
Article
Pharmacology & Pharmacy
Brian Le Moal, Elise Lepeltier, Dominique Rouleau, Catherine Le Visage, Jean-Pierre Benoit, Catherine Passirani, Jerome Guicheux, Marion Fusellier, Johann Clouet
Summary: This study successfully formulated miR-155-loaded lipid nanocapsules (LNC) and demonstrated their potential and safety in vitro and in a healthy sheep model. This research provides an important foundation for the delivery of miR using nanotechnology in the treatment of disc degeneration disease.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Cell & Tissue Engineering
Anwu Xuan, Dike Ruan, Chaofeng Wang, Qing He, Deli Wang, Lisheng Hou, Chao Zhang, Chao Li, Wei Ji, Tianyong Wen, Cheng Xu, Zhenbiao Zhu
Summary: The treatment of intervertebral disc degeneration is a challenge. This study combines surgery and cell therapy to evaluate the safety and feasibility of autologous discogenic cells transplantation combined with discectomy in treating lumbar disc herniation. The results show that this combined treatment can slow down disc degeneration and reduce surgical complications.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Clinical Neurology
Yoshiki Takeoka, Yutaro Kanda, James D. Kang, Shuichi Mizuno
Summary: Isolated human nucleus pulposus (hNP) cells from degenerated IVD were treated under high osmolality and evaluated for regenerative potential. The study found that mild to moderate degenerated cells can promote extracellular matrix production and maintain cell viability under physiological spinal loading. This study explored the potential of degenerated cells in a physiological environment, which may lead to strategies for IVD regeneration.
Article
Orthopedics
Fu Zhang, Songjuan Wang, Baoliang Li, Wei Tian, Zhiyu Zhou, Shaoyu Liu
Summary: Low back pain is a common clinical issue caused by intervertebral disc degeneration. Current treatments are limited due to their inability to address the underlying degeneration. Intradiscal injection therapies have shown benefits in symptomatic relief and disc repair, but there are limitations to consider.
Article
Rehabilitation
William R. Reed, Michael A. K. Liebschner, Carla R. Lima, Harshvardhan Singh, Christopher P. Hurt, Daniel F. Martins, James M. Cox, Maruti R. Gudavalli
Summary: This study reports the in vivo changes in intradiscal pressure (IDP) using clinically available instrument-assisted spinal manipulation devices and/or spinal mobilization procedures in cats for the first time. The results suggest that a feline model can be used to investigate IDP changes related to spinal manual therapy mechanisms and the dampening effect of viscoelastic properties of spinal tissues on these manipulative forces. Further investigation of IDP changes in this and/or other in vivo animal models is needed to gain better insights into the physiological effects and mechanisms of spinal manual therapy at the intervertebral disc level.
CHIROPRACTIC & MANUAL THERAPIES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marcus Raudner, Markus M. Schreiner, Tom Hilbert, Tobias Kober, Michael Weber, Anna Szelenyi, Reinhard Windhager, Vladimir Juras, Siegfried Trattnig
Summary: The study evaluated GRAPPATINI, an accelerated T-2 mapping sequence that combines undersampling and model-based reconstruction to facilitate clinical implementation of T-2 mapping of the lumbar intervertebral disc. Results showed that T2 values obtained using GRAPPATINI were significantly different for normal discs compared to bulging or herniated discs, as well as discs with and without annular tears. The study concluded that GRAPPATINI can be used as a quantitative imaging biomarker to detect disc pathologies while significantly reducing acquisition time.
EUROPEAN RADIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Chloe Techens, Sara Montanari, Ferenc Bereczki, Peter Endre Eltes, Aron Lazary, Luca Cristofolini
Summary: With the ageing of the population, there is a growing demand for minimally invasive spine surgeries. This study developed an in vitro model of percutaneous cement discoplasty and found that it restored disc height and reduced range of motion without increasing the risk of tissue damage.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Veronica Tilotta, Gianluca Vadala, Luca Ambrosio, Claudia Cicione, Giuseppina Di Giacomo, Fabrizio Russo, Rocco Papalia, Vincenzo Denaro
Summary: This study evaluated the effect of BM-MSCs and ADSCs secretomes on hNPCs, showing positive results in vitro and suggesting potential applications in treating intervertebral disc degeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Cell & Tissue Engineering
K. Kato, K. Akeda, S. Miyazaki, J. Yamada, C. Muehleman, K. Miyamoto, Y. A. Asanuma, K. Asanuma, T. Fujiwara, M. E. Lenz, T. Nakazawa, H. An, K. Masuda
Summary: NF-kappa B decoy injection shows potential as an effective therapeutic strategy for discogenic pain associated with degenerated intervertebral discs, as it suppresses inflammatory responses and restores disc height loss.
EUROPEAN CELLS & MATERIALS
(2021)
Article
Medicine, General & Internal
Meng-Yin Yang, Chin-Hwee Goh, Chin-Ying Wu, You-Pen Chiu, Hui-Ru Ji, I-Han Hsiao, Cheng-Di Chiu
Summary: The study evaluated the general and radiographic features for predicting the therapeutic outcome of Intradiscal biacuplasty (IDB) in treating lumbar degenerative disc disease (DDD). The results showed that IDB is a good alternative choice for treating lumbar DDD. Patients with a painful extrusion lumbar disc may gain some benefits after receiving IDB following a period of failed conservative treatment.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Minhyeok Heo, Jihwan Yun, Hanjong Kim, Sang-Soo Lee, Seonghun Park
Summary: This study aimed to optimize a lumbar interspinous fixation device (LIFD) using a finite element model, allowing for minimally invasive surgery without compromising the normal behavior of the lumbar spine. The optimum number of spring turns and spring wire diameter were determined based on the dynamic range of motion (ROM) perspective. The optimized device was found to enhance stability and reduce the risk of degenerative diseases in adjacent lumbar segments.
Review
Orthopedics
G. Chao-yang, C. Peng, Z. Hai-hong
Summary: This article summarizes the role of the NLRP3 inflammasome in the pathogenesis of IVDD and its application in treatment.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Engineering, Biomedical
Michael Zenzes, Emely L. Bortel, Peter Fratzl, Stefan Mundlos, Michael Schuetz, Hendrik Schmidt, Georg N. Duda, Frank Witte, Paul Zaslansky
ACTA BIOMATERIALIA
(2019)
Article
Biophysics
Maxim Bashkuev, Sandra Reitmaier, Hendrik Schmidt
JOURNAL OF BIOMECHANICS
(2019)
Article
Biophysics
Andrea Calvo-Echenique, Maxim Bashkuev, Sandra Reitmaier, Amaya Perez-del Palomar, Hendrik Schmidt
JOURNAL OF BIOMECHANICS
(2019)
Article
Biophysics
Christopher T. Swain, Fumin Pan, Patrick J. Owen, Hendrik Schmidt, Daniel L. Belavy
JOURNAL OF BIOMECHANICS
(2020)
Article
Biophysics
Thomas Zander, Fumin Pan, Hendrik Schmidt
JOURNAL OF BIOMECHANICS
(2020)
Article
Biophysics
Maxim Bashkuev, Sandra Reitmaier, Hendrik Schmidt
JOURNAL OF BIOMECHANICS
(2020)
Article
Biophysics
Fumin Pan, Ali Firouzabadi, Thomas Zander, Hendrik Schmidt
JOURNAL OF BIOMECHANICS
(2020)
Article
Biophysics
Farshid Ghezelbash, Hendrik Schmidt, Aboulfazl Shirazi-Adl, Marwan El-Rich
JOURNAL OF BIOMECHANICS
(2020)
Article
Biophysics
Philipp Damm, Sandra Reitmaier, Sabine Hahn, Vivian Waldheim, Ali Firouzabadi, Hendrik Schmidt
JOURNAL OF BIOMECHANICS
(2020)
Article
Chemistry, Analytical
Mahmut Enes Kayaalp, Alison N. Agres, Jan Reichmann, Maxim Bashkuev, Georg N. Duda, Roland Becker
Article
Engineering, Biomedical
Fumin Pan, Thomas Zander, Sandra Reitmaier, Maxim Bashkuev, Hendrik Schmidt
CLINICAL BIOMECHANICS
(2019)
Article
Biophysics
Sandra Reitmaier, Hendrik Schmidt
JOURNAL OF BIOMECHANICS
(2020)
Editorial Material
Biophysics
Aboulfazl Shirazi-Adl, Hendrik Schmidt, Idsart Kingma
JOURNAL OF BIOMECHANICS
(2020)
Article
Biophysics
Nathan D. Camarillo, Rafael Jimenez-Silva, Frances T. Sheehan
Summary: This article discusses the statistical dependence between multiple measurements from the same participant and provides recommendations for using these measurements when they are not independent.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
J. Huet, A. -S. Boureau, A. Sarcher, C. Cornu, A. Nordez
Summary: Standard compression in freehand 3D ultrasound induces a bias in volume calculations, but minimal compression and gel pad methods have similar results. With a trained examiner and precautions, the bias can be minimized and become acceptable in clinical applications.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
C. Lariviere, A. H. Eskandari, H. Mecheri, F. Ghezelbash, D. Gagnon, A. Shirazi-Adl
Summary: Recent developments in musculoskeletal modeling have focused on model customization. Personalization of the spine profile may affect estimates of spinal loading and stability. This study investigates the biomechanical consequences of changes in the spinal profile and finds that personalizing the spine profile has medium to large effects on trunk muscle forces and negligible to small effects on spinal loading and stability.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Luke T. Mattar, Arash B. Mahboobin, Adam J. Popchak, William J. Anderst, Volker Musahl, James J. Irrgang, Richard E. Debski
Summary: Exercise therapy fails in about 25.0% of cases for individuals with rotator cuff tears, and one reason for this failure may be the inability to strengthen and balance the muscle forces that keep the humeral head in the correct position. This study developed computational musculoskeletal models to compare the net muscle force before and after exercise therapy between successfully and unsuccessfully treated patients. The study found that unsuccessfully treated patients had less inferiorly oriented net muscle forces, which may increase the risk of impingement.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Natsuki Sado, Takeshi Edagawa, Toshihide Fujimori, Shogo Hashimoto, Yoshikazu Okamoto, Takahito Nakajima
Summary: The existing methods for predicting hip and lumbosacral joint centres in Japanese adults are biased and differ between sexes. We propose new regression equations that consider soft-tissue thickness, sex differences, and a height-directional measure, and validate them using leave-one-out cross-validation.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Peimin Yu, Xuanzhen Cen, Qichang Mei, Alan Wang, Yaodong Gu, Justin Fernandez
Summary: This study aimed to explore the intra-foot biomechanical differences among individuals with chronic ankle instability (CAI), copers, and healthy individuals during dynamic tasks. The study found that copers and CAI individuals had smaller dorsiflexion angles and copers presented a more eversion position compared to healthy participants. Copers also had greater dorsiflexion angles in the metatarsophalangeal joint and more inversion moments in the subtalar joint during certain tasks. These findings can help in designing interventions to restore ankle joint functions in CAI individuals.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Jon Skovgaard Jensen, Anders Holsgaard-Larsen, Anders Stengaard Sorensen, Per Aagaard, Jens Bojsen-Moller
Summary: This study investigates the biomechanical effects of robot-assisted body weight unloading (BWU) on gait patterns in healthy young adults. The results show that dynamic robot-assisted BWU enables reduced kinetic requirements without distorting biomechanically normal gait patterns during overground walking.
JOURNAL OF BIOMECHANICS
(2024)