The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors

Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model

(2015) Madhusudhan Tarigopula et al.   CARDIOVASCULAR RESEARCH

Design, Characterization, and First-In-Human Study of the Vascular Actions of a Novel Biased Apelin Receptor Agonist

(2015) A. L. Brame et al.   HYPERTENSION

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

(2015) Yanyong Kang et al.   NATURE

Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and 19F-NMR

(2015) Fan Yang et al.   Nature Communications

Structural evidence for the role of polar core residue Arg175 in arrestin activation

(2015) Joachim Granzin et al.   Scientific Reports

Visualization of arrestin recruitment by a G-protein-coupled receptor

(2014) Arun K. Shukla et al.   NATURE

Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers

(2014) David G. Soergel et al.   PAIN

What is biased efficacy? Defining the relationship between intrinsic efficacy and free energy coupling

(2014) H. Ongun Onaran et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Crystal structure of a common GPCR-binding interface for G protein and arrestin

(2014) Michal Szczepek et al.   Nature Communications

Role of β-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking

(2013) Dong Soo Kang et al.   CURRENT OPINION IN CELL BIOLOGY

Noncanonical Control of Vasopressin Receptor Type 2 Signaling by Retromer and Arrestin

(2013) Timothy N. Feinstein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arrestin-3 Binds c-Jun N-terminal Kinase 1 (JNK1) and JNK2 and Facilitates the Activation of These Ubiquitous JNK Isoforms in Cells via Scaffolding

(2013) Seunghyi Kook et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Constitutive Internalization of the Leucine-rich G Protein-coupled Receptor-5 (LGR5) to the Trans-Golgi Network

(2013) Joshua C. Snyder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of pre-activated arrestin p44

(2013) Yong Ju Kim et al.   NATURE

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

(2013) Arun K. Shukla et al.   NATURE

Conformational biosensors reveal GPCR signalling from endosomes

(2013) Roshanak Irannejad et al.   NATURE

Noncanonical GPCR signaling arising from a PTH receptor–arrestin–Gβγ complex

(2013) Vanessa L. Wehbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRV120027, a Novel β-Arrestin Biased Ligand at the Angiotensin II Type I Receptor, Unloads the Heart and Maintains Renal Function When Added to Furosemide in Experimental Heart Failure

(2012) Guido Boerrigter et al.   Circulation-Heart Failure

Manipulation of Very Few Receptor Discriminator Residues Greatly Enhances Receptor Specificity of Non-visual Arrestins

(2012) Luis E. Gimenez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Silent Scaffolds

(2012) Maya Breitman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Cellular and Subcellular Distributions of G Protein-Coupled Receptor Kinase and Arrestin Isoforms in the Striatum

(2012) Evgeny Bychkov et al.   PLoS One

Conformation of receptor-bound visual arrestin

(2012) M. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An expanded family of arrestins regulate metabolism

(2012) Parth Patwari et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A Simple Method for Quantifying Functional Selectivity and Agonist Bias

(2011) Terry Kenakin et al.   ACS Chemical Neuroscience

Crystal Structure of Arrestin-3 Reveals the Basis of the Difference in Receptor Binding Between Two Non-visual Subtypes

(2011) Xuanzhi Zhan et al.   JOURNAL OF MOLECULAR BIOLOGY

Quantifying Ligand Bias at Seven-Transmembrane Receptors

(2011) S. Rajagopal et al.   MOLECULAR PHARMACOLOGY

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Distinct Phosphorylation Sites on the  2-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of  -Arrestin

(2011) K. N. Nobles et al.   Science Signaling

Site-specific Phosphorylation of CXCR4 Is Dynamically Regulated by Multiple Kinases and Results in Differential Modulation of CXCR4 Signaling

(2010) John M. Busillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential G-protein-coupled Receptor Phosphorylation Provides Evidence for a Signaling Bar Code

(2010) Adrian J. Butcher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Ubiquitin-like Modifier Modification of Arrestin-3 Regulates Receptor Trafficking

(2010) Debra Wyatt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arrestin-2 Interacts with the Endosomal Sorting Complex Required for Transport Machinery to Modulate Endosomal Sorting of CXCR4

(2010) Rohit Malik et al.   MOLECULAR BIOLOGY OF THE CELL

Teaching old receptors new tricks: biasing seven-transmembrane receptors

(2010) Sudarshan Rajagopal et al.   NATURE REVIEWS DRUG DISCOVERY

Helix Formation in Arrestin Accompanies Recognition of Photoactivated Rhodopsin

(2009) Sophie E. Feuerstein et al.   BIOCHEMISTRY

The deubiquitinases USP33 and USP20 coordinate β2 adrenergic receptor recycling and resensitization

(2009) Magali Berthouze et al.   EMBO JOURNAL

Structure of an Arrestin2-Clathrin Complex Reveals a Novel Clathrin Binding Domain That Modulates Receptor Trafficking

(2009) Dong Soo Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2

(2009) S. K. Shenoy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands

(2009) D. A. Zidar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

S-Nitrosylation of β-Arrestin Regulates β-Adrenergic Receptor Trafficking

(2008) Kentaro Ozawa et al.   MOLECULAR CELL

M3 Muscarinic Acetylcholine Receptor-Mediated Signaling Is Regulated by Distinct Mechanisms

(2008) J. Luo et al.   MOLECULAR PHARMACOLOGY

Estimation of Relative Microscopic Affinity Constants of Agonists for the Active State of the Receptor in Functional Studies on M2 and M3 Muscarinic Receptors

(2008) J. A. Tran et al.   MOLECULAR PHARMACOLOGY

 -Arrestin-Mediated Localization of Smoothened to the Primary Cilium

(2008) J. J. Kovacs et al.   SCIENCE

Location, location, location…site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling

(2008) Andrew B. Tobin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES