Biophysical Evidence for Intrinsic Disorder in the C-terminal Tails of the Epidermal Growth Factor Receptor (EGFR) and HER3 Receptor Tyrosine Kinases

A practical guide to small angle X-ray scattering (SAXS) of flexible and intrinsically disordered proteins

(2015) Alexey G. Kikhney et al.   FEBS LETTERS

Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor

(2015) Erika Kovacs et al.   MOLECULAR AND CELLULAR BIOLOGY

Introducing Protein Intrinsic Disorder

(2014) Johnny Habchi et al.   CHEMICAL REVIEWS

Mapping Residual Structure in Intrinsically Disordered Proteins at Residue Resolution Using Millisecond Hydrogen/Deuterium Exchange and Residue Averaging

(2014) Theodore R. Keppel et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Presence and utility of intrinsically disordered regions in kinases

(2014) Jaymin J. Kathiriya et al.   Molecular BioSystems

The EGFR Family: Not So Prototypical Receptor Tyrosine Kinases

(2014) M. A. Lemmon et al.   Cold Spring Harbor Perspectives in Biology

Coarse-Grained Molecular Simulation of Epidermal Growth Factor Receptor Protein Tyrosine Kinase Multi-Site Self-Phosphorylation

(2014) John G. Koland   PLoS Computational Biology

Analysis of Disordered Proteins Using a Simple Apparatus for Millisecond Quench-Flow H/D Exchange

(2013) Theodore R. Keppel et al.   ANALYTICAL CHEMISTRY

The most important thing is the tail: Multitudinous functionalities of intrinsically disordered protein termini

(2013) Vladimir N. Uversky   FEBS LETTERS

Carboxyl Group Footprinting Mass Spectrometry and Molecular Dynamics Identify Key Interactions in the HER2-HER3 Receptor Tyrosine Kinase Interface

(2013) Timothy S. Collier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Designability of Protein Switches by Chemical Rescue of Structure: Mechanisms of Inactivation and Reactivation

(2013) Yan Xia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Time Window Expansion for HDX Analysis of an Intrinsically Disordered Protein

(2013) Devrishi Goswami et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

EGFR: Tale of the C-terminal tail

(2013) Ketan S. Gajiwala   PROTEIN SCIENCE

Measuring Dynamics in Weakly Structured Regions of Proteins Using Microfluidics-Enabled Subsecond H/D Exchange Mass Spectrometry

(2012) Tamanna Rob et al.   ANALYTICAL CHEMISTRY

Rate constants and mechanisms of intrinsically disordered proteins binding to structured targets

(2012) Huan-Xiang Zhou et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Mapping Unstructured Regions and Synergistic Folding in Intrinsically Disordered Proteins with Amide H/D Exchange Mass Spectrometry

(2011) Theodore R. Keppel et al.   BIOCHEMISTRY

Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein

(2011) Kathleen Aertgeerts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intrinsic disorder in cell signaling and gene transcription

(2011) Agnes Tantos et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Structural analysis of intrinsically disordered proteins by small-angle X-ray scattering

(2011) Pau Bernadó et al.   Molecular BioSystems

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Understanding protein non-folding

(2010) Vladimir N. Uversky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Hydrogen exchange mass spectrometry for studying protein structure and dynamics

(2010) Lars Konermann et al.   CHEMICAL SOCIETY REVIEWS

EGFRvIV: a previously uncharacterized oncogenic mutant reveals a kinase autoinhibitory mechanism

(2010) G Pines et al.   ONCOGENE

Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidation

(2010) Zhongqi Zhang et al.   PROTEIN SCIENCE

Her4 and Her2/neu Tyrosine Kinase Domains Dimerize and Activate in a Reconstitutedin VitroSystem

(2009) John Monsey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetic Advantage of Intrinsically Disordered Proteins in Coupled Folding–Binding Process: A Critical Assessment of the “Fly-Casting” Mechanism

(2009) Yongqi Huang et al.   JOURNAL OF MOLECULAR BIOLOGY

Prediction of the Rotational Tumbling Time for Proteins with Disordered Segments

(2009) Sung-Hun Bae et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS)

(2009) Greg L Hura et al.   NATURE METHODS

Toward a quantitative theory of intrinsically disordered proteins and their function

(2009) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3

(2009) N. Jura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrinsically Disordered Proteins in Human Diseases: Introducing the D2 Concept

(2008) Vladimir N. Uversky et al.   Annual Review of Biophysics

The unfoldomics decade: an update on intrinsically disordered proteins

(2008) A Keith Dunker et al.   BMC GENOMICS

Function and structure of inherently disordered proteins

(2008) A Keith Dunker et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Protein secondary structure analyses from circular dichroism spectroscopy: Methods and reference databases

(2007) Lee Whitmore et al.   BIOPOLYMERS