Article
Biochemistry & Molecular Biology
Wenqiang Tao, Fen Liu, Jianguo Zhang, Shangmiao Fu, Hui Zhan, Kejian Qian
Summary: This study investigated the miRNA-mRNA regulatory networks involved in ferroptosis following renal ischemia-reperfusion injury. The results showed that inhibition of miR-3587 promotes upregulation of HO-1, thereby protecting renal tissues from IR-induced ferroptosis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Editorial Material
Hematology
Nipon Chattipakorn
Summary: Excess free heme and reduced hemopexin in sickle cell disease can lead to the overload of ferrous ion in cardiac cells, promoting cardiomyocyte ferroptosis and potentially impairing cardiac contractility.
Article
Plant Sciences
Jian Ye, Tian-Jiao Lyu, Ling-Yan Li, Ying Liu, Hong Zhang, Xu Wang, Xin Xi, Zong-Jun Liu, Jun-Qing Gao
Summary: This study investigates the protective mechanism of Ginsenoside Re and the role of ferroptosis in myocardial ischemia/reperfusion injury. The findings suggest that Ginsenoside Re attenuates ferroptosis induced by myocardial ischemia/reperfusion through the miR-144-3p/SLC7A11 pathway, thereby reducing cardiac damage.
Article
Pharmacology & Pharmacy
Fang Zheng, Jian-Can Bi, Yu-Yan Wei, Yeshu Wang, Qunfang Zhang, Chun-Ling Liang, Jianwei Wu, Zhenhua Dai
Summary: The study demonstrated that PPI promotes gastric cancer cell ferroptosis by regulating miR-124-3p, which leads to tumor suppression.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ying Zhang, Meiying Luo, Xiaohong Cui, Douglas O'Connell, Yongfei Yang
Summary: This study reveals the important role of NEAT1 in regulating ferroptosis in tumors, and enhances the effect of ferroptosis by modulating miR-362-3p and MIOX. Therefore, ferroptosis induction may be a promising therapeutic strategy for HCC patients with high NEAT1 expression.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Neurosciences
Zerui Zhuang, Mingfa Liu, Zhuozhi Dai, Jianming Luo, Bingna Zhang, Hanhui Yu, Jiajian Xue, Haixiong Xu
Summary: This research explores the therapeutic effects of miR-124-3p obtained from bone marrow stromal cell-derived exosomes (BMSCs-Exos) in attenuating glutamate-mediated excitotoxicity in traumatic brain injury (TBI). The findings show that BMSCs-ExosmiR-124-3p can upregulate GLT-1 in TBI rat models by inhibiting the p38 MAPK signaling pathway, reducing glutamate-mediated excitotoxicity and attenuating neurological damage post-TBI.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Zhen Liang, Zhaoshi Zheng, Qi Guo, Meng Tian, Jing Yang, Xiu Liu, Xiaojuan Zhu, Songyan Liu
Summary: This study investigates the role of hypoxia-inducible factor (HIF)-1 alpha/heme oxygenase (HO)-1 in hippocampal neuron ferroptosis during epilepsy. The results suggest that there are metabolic differences between epilepsy patients and healthy individuals, with increased oxidative stress, heightened bilirubin, and augmented iron metabolism in epileptic blood. The active HIF-1 pathway in epileptic pathogenesis and perturbations in HIF-1 alpha signaling are reinforced by the analysis. The study implicates that HIF-1 alpha/HO-1 potentially regulates hippocampal neuronal ferroptosis, iron metabolism, and oxidative stress, thereby promoting the propagation of epilepsy.
Article
Cell Biology
Chong Huang, Lu Zhao, Yun Xiao, Zihao Tang, Li Jing, Kai Guo, Lei Tian, Chunlin Zong
Summary: This study aimed to investigate the role of macrophages and macrophage-derived exosomes in restoring irradiated bone marrow mesenchymal stem cells (BMMSCs) function. M2 macrophage-derived exosomes (M2D-exos) were found to inhibit the fibrogenic differentiation and promote the osteogenic differentiation of irradiated BMMSCs. The miRNA miR-142-3p in M2D-exos targeted transforming growth factor beta 1 (TGF-beta 1) to restore the differentiation balance of irradiated BMMSCs. These findings provide a promising and cell-free method to treat irradiation-induced bone damage.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Yong Wang, Huicong Niu, Luyu Li, Jing Han, Zhuohang Liu, Min Chu, Xianyi Sha, Jing Zhao
Summary: This study aimed to design and prepare anti-ferroptosis exosomes (ADSC-Exo) from adipose-derived mesenchymal stem cells for treating ischemic brain injury. It was found that IN administration of ADSC-Exo effectively improved the neurobehavior function and ferroptosis-related outcomes in mice after ischemia/reperfusion injury. The results also demonstrated that ADSC-Exo inhibited ferroptosis by targeting CHAC1 in neurons.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Cell & Tissue Engineering
Xiaoxuan Zhao, Mingxi Xu, Xuemeng Hu, Xiaolei Ding, Xian Zhang, Liye Xu, Li Li, Xiuhua Sun, Jincheng Song
Summary: This study investigates the role of exosomes derived from human bone marrow mesenchymal stem cells (hBMSCs) carrying microRNA-124-3p in the development of diffuse large B cell lymphoma (DLBCL). It is found that miR-124-3p negatively regulates the expression of NFATc1, inhibiting DLBCL cell proliferation and promoting apoptosis. Through downregulation of NFATc1, hBMSC-miR-124-3p represses the development of DLBCL.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Zejia Sun, Zihao Gao, Jiyue Wu, Xiang Zheng, Shizhao Jing, Wei Wang
Summary: This study confirmed the protective role of BMSC-derived EVs and exosome-delivered miR-223-3p in RIRI. Exogenous miR-223-3p enhanced mitophagy by directly targeting NLRP3 to attenuate inflammasome activation.
STEM CELLS INTERNATIONAL
(2022)
Article
Anatomy & Morphology
Dongyu Lei, Biao Li, Zuribia Isa, Xiaoqiang Ma, Baojian Zhang
Summary: This study aimed to investigate the role and potential mechanisms of hypoxia-conditioned cardiac microvascular endothelial cells (CMECs)-derived Exo (H-exo) in hypoxia/reoxygenation (H/R)-induced cardiomyocytes damages. The results demonstrated that miR-210-3p derived from H-exo promoted the proliferation of myocardial cells in H/R-treated cells by suppressing TFR-mediated ferroptosis.
Article
Cell Biology
Jian Wang, Fei Teng, Shuhan Liu, Xiaoqiang Pan, Bo Yang, Wei Wu
Summary: In this study, the effects of ICH-exos on HMC3 cells and the ceRNA network involving lncRNA SND1-IT1 were investigated. The results showed that ICH-exos delivered lncRNA SND1-IT1 to HMC3 cells, leading to decreased cell viability and increased apoptosis. The ceRNA network involving lncRNA SND1-IT1/miR-124-3p/MTF1 was found to play a role in regulating cell growth.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Medicine, Research & Experimental
Zhijun Meng, Hongping Liang, Jianli Zhao, Jia Gao, Caihong Liu, Xinliang Ma, Jing Liu, Bin Liang, Xiangying Jiao, Jimin Cao, Yajing Wang
Summary: Through unbiased bioinformatics analysis, we identified the crucial roles of ferroptosis and HMOX1 gene in diabetic atherosclerotic vascular disease. Experimental evidence showed that the ferroptosis inhibitor Ferrostatin-1 effectively attenuated diabetic atherosclerosis, indicating the causative role of ferroptosis in the development of diabetic atherosclerosis.
Article
Cardiac & Cardiovascular Systems
Weixin Sun, Ruijie Shi, Jun Guo, Haiyan Wang, Le Shen, Haibo Shi, Peng Yu, Xiaohu Chen
Summary: The study found that miR-135b-3p promotes ferroptosis in cardiomyocyte ischemia/reperfusion injury by inhibiting the GPX4 gene. This provides a new therapeutic target for improving I/R injury.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)