Duplex interrogation by a direct DNA repair protein in search of base damage

Timing facilitated site transfer of an enzyme on DNA

(2012) Joseph D Schonhoft et al.   Nature Chemical Biology

Down-regulation of ALKBH2 increases cisplatin sensitivity in H1299 lung cancer cells

(2011) Shuang-shuang Wu et al.   ACTA PHARMACOLOGICA SINICA

Cosolute Paramagnetic Relaxation Enhancements Detect Transient Conformations of Human Uracil DNA Glycosylase (hUNG)

(2011) Yan Sun et al.   BIOCHEMISTRY

Substitution of Active Site Tyrosines with Tryptophan Alters the Free Energy for Nucleotide Flipping by Human Alkyladenine DNA Glycosylase

(2011) Jenna M. Hendershot et al.   BIOCHEMISTRY

DNA Unwinding by ASCC3 Helicase Is Coupled to ALKBH3-Dependent DNA Alkylation Repair and Cancer Cell Proliferation

(2011) Sebastian Dango et al.   MOLECULAR CELL

Hopping Enables a DNA Repair Glycosylase To Search Both Strands and Bypass a Bound Protein

(2010) Mark Hedglin et al.   ACS Chemical Biology

Detection of Damaged DNA Bases by DNA Glycosylase Enzymes

(2010) Joshua I. Friedman et al.   BIOCHEMISTRY

Structure ofEscherichia coliAlkA in Complex with Undamaged DNA

(2010) Brian R. Bowman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic insight into the recognition of single-stranded and double-stranded DNA substrates by ABH2 and ABH3

(2010) Baoen Chen et al.   Molecular BioSystems

An unprecedented nucleic acid capture mechanism for excision of DNA damage

(2010) Emily H. Rubinson et al.   NATURE

Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase

(2010) Chengqi Yi et al.   NATURE

Divergent β-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3

(2010) Vivi Talstad Monsen et al.   NUCLEIC ACIDS RESEARCH

Structure determination of DNA methylation lesions N 1 -meA and N 3 -meC in duplex DNA using a cross-linked protein–DNA system

(2010) Lianghua Lu et al.   NUCLEIC ACIDS RESEARCH

A Non-Heme Iron-Mediated Chemical Demethylation in DNA and RNA

(2009) Chengqi Yi et al.   ACCOUNTS OF CHEMICAL RESEARCH

Kinetic Mechanism for the Flipping and Excision of 1,N6-Ethenoadenine by Human Alkyladenine DNA Glycosylase

(2009) Abigail E. Wolfe et al.   BIOCHEMISTRY

Using the Bias from Flow to Elucidate Single DNA Repair Protein Sliding and Interactions with DNA

(2009) Yihan Lin et al.   BIOPHYSICAL JOURNAL

Damage Detection and Base Flipping in Direct DNA Alkylation Repair

(2009) Cai-Guang Yang et al.   CHEMBIOCHEM

Identification of a novel, widespread, and functionally important PCNA-binding motif

(2009) Karin M. Gilljam et al.   JOURNAL OF CELL BIOLOGY

Pediatric brain tumors: mutations of two dioxygenases (hABH2 and hABH3) that directly repair alkylation damage

(2009) Valentina Cetica et al.   JOURNAL OF NEURO-ONCOLOGY

A DFT Study of Nucleobase Dealkylation by the DNA Repair Enzyme AlkB

(2009) Haining Liu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme

(2009) Yan Qi et al.   NATURE

Flipping of alkylated DNA damage bridges base and nucleotide excision repair

(2009) Julie L. Tubbs et al.   NATURE

Nonspecifically bound proteins spin while diffusing along DNA

(2009) Paul C Blainey et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Enzymological and structural studies of the mechanism of promiscuous substrate recognition by the oxidative DNA repair enzyme AlkB

(2009) B. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

AlkB Homologue 2-Mediated Repair of Ethenoadenine Lesions in Mammalian DNA

(2008) J. Ringvoll et al.   CANCER RESEARCH

Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA

(2008) Cai-Guang Yang et al.   NATURE

Structure of the E. coli DNA Glycosylase AlkA Bound to the Ends of Duplex DNA: A System for the Structure Determination of Lesion-Containing DNA

(2008) Brian R. Bowman et al.   STRUCTURE

Mammalian DNA Methyltransferases: A Structural Perspective

(2008) Xiaodong Cheng et al.   STRUCTURE