Up-regulation of N-cadherin by Collagen I-activated Discoidin Domain Receptor 1 in Pancreatic Cancer Requires the Adaptor Molecule Shc1

Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma

(2016) Chiara Ambrogio et al.   NATURE MEDICINE

Novel Role of Src in Priming Pyk2 Phosphorylation

(2016) Ming Zhao et al.   PLoS One

The GST-BHMT assay reveals a distinct mechanism underlying proteasome inhibition-induced macroautophagy in mammalian cells

(2015) Yan-Ning Rui et al.   Autophagy

Anticancer Effects of Mesothelin-Targeted Immunotoxin Therapy Are Regulated by Tyrosine Kinase DDR1

(2015) Fatima Ali-Rahmani et al.   CANCER RESEARCH

Small Molecule Discoidin Domain Receptor Kinase Inhibitors and Potential Medical Applications

(2015) Yupeng Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation

(2015) Valeria Iansante et al.   Nature Communications

Abstract 182: SPARC as a regulator of collagen signaling in pancreatic cancer

(2015) Kristina Y. Aguilera et al.   CANCER RESEARCH

Pancreatic Adenocarcinoma

(2015) David P. Ryan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Systematic Analysis of Phosphotyrosine Antibodies Recognizing Single Phosphorylated EPIYA-Motifs in CagA of Western-Type Helicobacter pylori Strains

(2014) Judith Lind et al.   PLoS One

Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor

(2013) Hyung-Gu Kim et al.   ACS Chemical Biology

Collagen Signaling Enhances Tumor Progression after Anti-VEGF Therapy in a Murine Model of Pancreatic Ductal Adenocarcinoma

(2013) K. Y. Aguilera et al.   CANCER RESEARCH

Aberrant Expression of Mucin Core Proteins and O-Linked Glycans Associated with Progression of Pancreatic Cancer

(2013) N. Remmers et al.   CLINICAL CANCER RESEARCH

Distinct Phosphotyrosine-dependent Functions of the ShcA Adaptor Protein Are Required for Transforming Growth Factor β (TGFβ)-induced Breast Cancer Cell Migration, Invasion, and Metastasis

(2013) Jason J. Northey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery and Optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as Novel Selective and Orally Bioavailable Discoidin Domain Receptor 1 (DDR1) Inhibitors

(2013) Mingshan Gao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Teaching an old dogma new tricks: twenty years of Shc adaptor signalling

(2012) Melanie K. B. Wills et al.   BIOCHEMICAL JOURNAL

Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors

(2012) Samit K. Bhattacharya et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discoidin domain receptor tyrosine kinases: new players in cancer progression

(2012) Rajeshwari R. Valiathan et al.   CANCER AND METASTASIS REVIEWS

Pyk2 cytonuclear localization: mechanisms and regulation by serine dephosphorylation

(2012) Camille Faure et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibition of Collagen Receptor Discoidin Domain Receptor-1 (DDR1) Reduces Cell Survival, Homing, and Colonization in Lung Cancer Bone Metastasis

(2012) K. Valencia et al.   CLINICAL CANCER RESEARCH

The Pancreas Cancer Microenvironment

(2012) C. Feig et al.   CLINICAL CANCER RESEARCH

SH3 domain ligand binding: What's the consensus and where's the specificity?

(2012) Kalle Saksela et al.   FEBS LETTERS

Phosphotyrosine mediated protein interactions of the discoidin domain receptor 1

(2011) Simone Lemeer et al.   Journal of Proteomics

EMT, the cytoskeleton, and cancer cell invasion

(2009) Mahmut Yilmaz et al.   CANCER AND METASTASIS REVIEWS

Proteomic, functional and motif-based analysis of C-terminal Src kinase-interacting proteins

(2009) Guang Yang et al.   PROTEOMICS

Protein-tyrosine kinase CAKβ/PYK2 is activated by binding Ca2+/calmodulin to FERM F2 α2 helix and thus forming its dimer

(2008) Takayuki Kohno et al.   BIOCHEMICAL JOURNAL

Collagen I–mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1

(2008) Yasushi Shintani et al.   JOURNAL OF CELL BIOLOGY

Cadherin switching

(2008) M. J. Wheelock et al.   JOURNAL OF CELL SCIENCE

The regulatory or phosphorylation domain of p120 catenin controls E-cadherin dynamics at the plasma membrane

(2007) Yuri Fukumoto et al.   EXPERIMENTAL CELL RESEARCH