The GST-BHMT assay reveals a distinct mechanism underlying proteasome inhibition-induced macroautophagy in mammalian cells

Macroautophagy-dependent, intralysosomal cleavage of a betaine homocysteine methyltransferase fusion protein requires stable multimerization

(2014) Carol A. Mercer et al.   Autophagy

Proteasome Dysfunction Activates Autophagy and the Keap1-Nrf2 Pathway

(2014) Shun Kageyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The kinase triad, AMPK, mTORC1 and ULK1, maintains energy and nutrient homoeostasis

(2013) Elaine A. Dunlop et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

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(2012) Daniel J. Klionsky et al.   Autophagy

Proteasome inhibition-induced p38 MAPK/ERK signaling regulates autophagy and apoptosis through the dual phosphorylation of glycogen synthase kinase 3β

(2012) Cheol-Hee Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Why is autophagy important in human diseases?

(2012) Kaipeng Jing et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Transient Aggregation of Ubiquitinated Proteins Is a Cytosolic Unfolded Protein Response to Inflammation and Endoplasmic Reticulum Stress

(2012) Xian-De Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates

(2012) J. Korac et al.   JOURNAL OF CELL SCIENCE

Failure of Amino Acid Homeostasis Causes Cell Death following Proteasome Inhibition

(2012) Amila Suraweera et al.   MOLECULAR CELL

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Proteasome inhibitor MG132-induced apoptosis via ER stress-mediated apoptotic pathway and its potentiation by protein tyrosine kinase p56lck in human Jurkat T cells

(2011) Hae Sun Park et al.   BIOCHEMICAL PHARMACOLOGY

p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding

(2011) Eisuke Itakura et al.   JOURNAL OF CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

The location of endogenous wild-type p53 protein in 293T and HEK293 cells expressing low-risk HPV-6E6 fusion protein with GFP

(2010) L. Sun et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Evidence for the interplay between JNK and p53-DRAM signaling pathways in the regulation of autophagy

(2010) Séverine Lorin et al.   Autophagy

mTORC1 signaling requires proteasomal function and the involvement of CUL4-DDB1 ubiquitin E3 ligase

(2010) Papia Ghosh et al.   CELL CYCLE

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(2010) Melinda A. Lynch-Day et al.   FEBS LETTERS

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

P Granule Assembly and Function in Caenorhabditis elegans Germ Cells

(2010) D. Updike et al.   JOURNAL OF ANDROLOGY

Nix Is Critical to Two Distinct Phases of Mitophagy, Reactive Oxygen Species-mediated Autophagy Induction and Parkin-Ubiquitin-p62-mediated Mitochondrial Priming

(2010) Wen-Xing Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective autophagy: ubiquitin-mediated recognition and beyond

(2010) Claudine Kraft et al.   NATURE CELL BIOLOGY

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(2010) Sharon A. Tooze et al.   NATURE CELL BIOLOGY

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

NBR1 co-operates with p62 in selective autophagy of ubiquitinated targets

(2009) Vladimir Kirkin et al.   Autophagy

SEPA-1 Mediates the Specific Recognition and Degradation of P Granule Components by Autophagy in C. elegans

(2009) Yuxia Zhang et al.   CELL

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Bortezomib

(2009) Monique P. Curran et al.   DRUGS

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

(2009) Viktor I. Korolchuk et al.   FEBS LETTERS

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling

(2009) Faraz K. Mardakheh et al.   JOURNAL OF CELL BIOLOGY

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism

(2009) Jozsef Gal et al.   JOURNAL OF NEUROCHEMISTRY

A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL