The Molecular Chaperone GRP78 Contributes to Toll-like Receptor 3-mediated Innate Immune Response to Hepatitis C Virus in Hepatocytes

A Role for APPL1 in TLR3/4-Dependent TBK1 and IKKε Activation in Macrophages

(2015) Tieu-Lan Chau et al.   JOURNAL OF IMMUNOLOGY

Immune Responses to HCV and Other Hepatitis Viruses

(2014) Su-Hyung Park et al.   IMMUNITY

An Interferon Response Gene Signature Is Associated with the Therapeutic Response of Hepatitis C Patients

(2014) Lawrence M. Pfeffer et al.   PLoS One

HSPD1 Interacts with IRF3 to Facilitate Interferon-Beta Induction

(2014) Lan Lin et al.   PLoS One

A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus

(2013) Ludmila Prokunina-Olsson et al.   NATURE GENETICS

Regulation of hepatic innate immunity by hepatitis C virus

(2013) Stacy M Horner et al.   NATURE MEDICINE

Hepatic Cell–Type Specific Gene Expression Better Predicts HCV Treatment Outcome Than IL28B Genotype

(2012) Ian McGilvray et al.   GASTROENTEROLOGY

TRIM56 Is an Essential Component of the TLR3 Antiviral Signaling Pathway

(2012) Yang Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Innate immune responses in hepatitis C virus infection

(2012) Kui Li et al.   Seminars in Immunopathology

ER stress-induced inflammation: does it aid or impede disease progression?

(2012) Abhishek D. Garg et al.   TRENDS IN MOLECULAR MEDICINE

Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting

(2011) Min Ni et al.   BIOCHEMICAL JOURNAL

Activation of chemokine and inflammatory cytokine response in hepatitis C virus-infected hepatocytes depends on toll-like receptor 3 sensing of hepatitis C virus double-stranded RNA intermediates

(2011) Kui Li et al.   HEPATOLOGY

Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity

(2010) Evelyn Dixit et al.   CELL

TBK1-associated Protein in Endolysosomes (TAPE) Is an Innate Immune Regulator Modulating the TLR3 and TLR4 Signaling Pathways

(2010) Chun-Hung Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Viral Induction of the Zinc Finger Antiviral Protein Is IRF3-dependent but NF-κB-independent

(2010) Nan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro

(2010) Po-Yuan Ke et al.   JOURNAL OF CLINICAL INVESTIGATION

No evidence of the unfolded protein response in patients with chronic hepatitis C virus infection

(2010) Stuart McPherson et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Hepatitis C virus NS2 protein triggers endoplasmic reticulum stress and suppresses its own viral replication

(2010) Annette von dem Bussche et al.   JOURNAL OF HEPATOLOGY

Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone

(2010) Bei Liu et al.   Nature Communications

Cell-Type Specific Gene Expression Signature in Liver Underlies Response to Interferon Therapy in Chronic Hepatitis C Infection

(2009) Limin Chen et al.   GASTROENTEROLOGY

Toll-Like Receptor 3 Mediates Establishment of an Antiviral State against Hepatitis C Virus in Hepatoma Cells

(2009) N. Wang et al.   JOURNAL OF VIROLOGY

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

(2009) Dongliang Ge et al.   NATURE

Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

(2009) David L. Thomas et al.   NATURE

IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy

(2009) Vijayaprakash Suppiah et al.   NATURE GENETICS

Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C

(2009) Yasuhito Tanaka et al.   NATURE GENETICS

HCV Induces Oxidative and ER Stress, and Sensitizes Infected Cells to Apoptosis in SCID/Alb-uPA Mice

(2009) Michael A. Joyce et al.   PLoS Pathogens

Vesicular Stomatitis Virus Enters Cells through Vesicles Incompletely Coated with Clathrin That Depend upon Actin for Internalization

(2009) David K. Cureton et al.   PLoS Pathogens

A molecular chaperone glucose-regulated protein 94 blocks apoptosis induced by virus infection

(2008) Song Hee Lee et al.   HEPATOLOGY

Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response

(2008) Donna Sir et al.   HEPATOLOGY

Hepatitis C Virus Infection Induces Apoptosis through a Bax-Triggered, Mitochondrion-Mediated, Caspase 3-Dependent Pathway

(2008) L. Deng et al.   JOURNAL OF VIROLOGY

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

(2008) You-Me Kim et al.   NATURE

Development of plaque assays for hepatitis C virus-JFH1 strain and isolation of mutants with enhanced cytopathogenicity and replication capacity

(2007) Yuko Sekine-Osajima et al.   VIROLOGY