Identification of Glycosylation Sites Essential for Surface Expression of the CaVα2δ1 Subunit and Modulation of the Cardiac CaV1.2 Channel Activity

N-glycosylation is essential for ileal ASBT function and protection against proteases

(2015) Saminathan Muthusamy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Nav1.5 channels can reach the plasma membrane through distinct N-glycosylation states

(2015) Aurélie Mercier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Structure of the voltage-gated calcium channel Cav1.1 complex

(2015) J. Wu et al.   SCIENCE

Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFα

(2015) Roozbeh Aschar-Sobbi et al.   Nature Communications

The R-Domain: Identification of an N-terminal Region of the α2δ-1 Subunit Which is Necessary and Sufficient for its Effects on Cav2.2 Calcium Currents

(2015) Lele Song et al.   Current Molecular Pharmacology

Atrial Fibrillation Complicated by Heart Failure Induces Distinct Remodeling of Calcium Cycling Proteins

(2015) Patrick Lugenbiel et al.   PLoS One

The role of protein N-glycosylation in neural transmission

(2014) H. Scott et al.   GLYCOBIOLOGY

Functional Characterization of CaVα2δ Mutations Associated with Sudden Cardiac Death

(2014) Benoîte Bourdin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin-specific protease USP2-45 acts as a molecular switch to promote α2δ-1-induced downregulation of Cav1.2 channels

(2014) Jean-Sebastien Rougier et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Individual IKs channels at the surface of mammalian cells contain two KCNE1 accessory subunits

(2014) L. D. Plant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional exofacially tagged N-type calcium channels elucidate the interaction with auxiliary  2 -1 subunits

(2014) J. S. Cassidy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of post-translational N-glycosylation by HRD1 that controls the fate of ABCG5/8 transporter

(2014) Shingo Suzuki et al.   Scientific Reports

Glycosylation regulates the function and membrane localization of KCC4

(2013) Tzu-Yu Weng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

False start: Cotranslational protein ubiquitination and cytosolic protein quality control

(2013) Sophie A. Comyn et al.   Journal of Proteomics

IKs channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits

(2013) K. J. Ruscic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β1- and β3- voltage-gated sodium channel subunits modulate cell surface expression and glycosylation of Nav1.7 in HEK293 cells

(2013) Cédric J. Laedermann et al.   Frontiers in Cellular Neuroscience

In-Silico Modeling of Glycosylation Modulation Dynamics in hERG Ion Channels and Cardiac Electrical Signals

(2013) Dongping Du et al.   IEEE Journal of Biomedical and Health Informatics

The α2δ subunits of voltage-gated calcium channels

(2012) Annette C. Dolphin   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structure and function of the β subunit of voltage-gated Ca2+ channels

(2012) Zafir Buraei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Trafficking mechanisms underlying neuronal voltage-gated ion channel localization at the axon initial segment

(2012) Helene Vacher et al.   EPILEPSIA

Transcriptional Upregulation of α 2 δ-1 Elevates Arterial Smooth Muscle Cell Voltage-Dependent Ca 2+ Channel Surface Expression and Cerebrovascular Constriction in Genetic Hypertension

(2012) John P. Bannister et al.   HYPERTENSION

Function and 3D Structure of the N-Glycans on Glycoproteins

(2012) Masamichi Nagae et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Quartet of Leucine Residues in the Guanylate Kinase Domain of CaVβ Determines the Plasma Membrane Density of the CaV2.3 Channel

(2012) Behzad Shakeri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-Glycosylation of TRPM8 Ion Channels Modulates Temperature Sensitivity of Cold Thermoreceptor Neurons

(2012) María Pertusa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flagging and docking: dual roles for N-glycans in protein quality control and cellular proteostasis

(2012) Daniel N. Hebert et al.   TRENDS IN BIOCHEMICAL SCIENCES

Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6)

(2011) C. Templin et al.   EUROPEAN HEART JOURNAL

Post-translationalN-Glycosylation of Type I Transmembrane KCNE1 Peptides

(2011) Tuba Bas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Double Mutant Cycle Analysis Identified a Critical Leucine Residue in the IIS4S5 Linker for the Activation of the CaV2.3 Calcium Channel

(2011) Sébastien Wall-Lacelle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting of Voltage-Gated Calcium Channel α2δ-1 Subunit to Lipid Rafts Is Independent from a GPI-Anchoring Motif

(2011) Philip Robinson et al.   PLoS One

Mutations in the cardiac L-type calcium channel associated with inherited J-wave syndromes and sudden cardiac death

(2010) Elena Burashnikov et al.   HEART RHYTHM

Molecular Determinants of the CaVβ-induced Plasma Membrane Targeting of the CaV1.2 Channel

(2010) Benoîte Bourdin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cavβ subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels

(2010) Christophe Altier et al.   NATURE NEUROSCIENCE

The  2  subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function

(2010) A. Davies et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted disruption of the voltage-dependent calcium channel α2/δ-1-subunit

(2009) Geraldine A. Fuller-Bicer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Metabolism, Cell Surface Organization, and Disease

(2009) James W. Dennis et al.   CELL

Calcium channel diversity: multiple roles of calcium channel subunits

(2009) Annette C Dolphin   CURRENT OPINION IN NEUROBIOLOGY

Disruption of N-linked glycosylation enhances ubiquitin-mediated proteasomal degradation of the human ATP-binding cassette transporter ABCG2

(2009) Hiroshi Nakagawa et al.   FEBS Journal

Three-dimensional Structure of CaV3.1

(2009) Conor P. Walsh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-glycans are direct determinants of CFTR folding and stability in secretory and endocytic membrane traffic

(2009) Rina Glozman et al.   JOURNAL OF CELL BIOLOGY

Supramolecular Assemblies and Localized Regulation of Voltage-Gated Ion Channels

(2009) Shuiping Dai et al.   PHYSIOLOGICAL REVIEWS

N-glycan structures: recognition and processing in the ER

(2009) Markus Aebi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Branched N-glycans regulate the biological functions of integrins and cadherins

(2008) Yanyang Zhao et al.   FEBS Journal

N-Glycan-mediated Quality Control in the Endoplasmic Reticulum Is Required for the Expression of Correctly Folded δ-Opioid Receptors at the Cell Surface

(2008) Piia M. H. Markkanen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological disruption of calcium channel trafficking by the  2  ligand gabapentin

(2008) J. Hendrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA