Dynamic Metabolic Response to (p)ppGpp Accumulation in Pseudomonas putida

Rational design of a new antibiotic class for drug-resistant infections

(2021) Thomas F. Durand-Reville et al.   NATURE

How the initiating ribosome copes with ppGpp to translate mRNAs

(2020) Daria S. Vinogradova et al.   PLOS BIOLOGY

Pseudomonas putida KT2440 is naturally endowed to withstand industrial-scale stress conditions

(2020) Andreas Ankenbauer et al.   Microbial Biotechnology

Metabolism of non-growing bacteria

(2020) Martin Lempp et al.   BIOLOGICAL CHEMISTRY

ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation

(2020) Boyuan Wang et al.   MOLECULAR CELL

The nucleotide pGpp acts as a third alarmone in Bacillus, with functions distinct from those of (p) ppGpp

(2020) Jin Yang et al.   Nature Communications

Crucial Role of ppGpp in the Resilience of Escherichia coli to Growth Disruption

(2020) Clément Patacq et al.   mSphere

Chemical and metabolic controls on dihydroxyacetone metabolism lead to a suboptimal growth of E. coli.

(2019) Camille Peiro et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

(p)ppGpp Regulates a Bacterial Nucleosidase by an Allosteric Two-Domain Switch

(2019) Yong Everett Zhang et al.   MOLECULAR CELL

GC-MS-based 13C metabolic flux analysis resolves the parallel and cyclic glucose metabolism of Pseudomonas putida KT2440 and Pseudomonas aeruginosa PAO1

(2019) Michael Kohlstedt et al.   METABOLIC ENGINEERING

An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp

(2019) Shehryar Ahmad et al.   NATURE

Breakdown of Vibrio cholerae biofilm architecture induced by antibiotics disrupts community barrier function

(2019) Francisco Díaz-Pascual et al.   Nature Microbiology

Reverse diauxie phenotype in Pseudomonas aeruginosa biofilm revealed by exometabolomics and label-free proteomics

(2019) Yeni P. Yung et al.   npj Biofilms and Microbiomes

Riboswitches for the alarmone ppGpp expand the collection of RNA-based signaling systems

(2018) Madeline E. Sherlock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel (p)ppGpp Binding and Metabolizing Proteins of Escherichia coli

(2018) Yong Zhang et al.   mBio

Escherichia coli translation strategies differ across carbon, nitrogen and phosphorus limitation conditions

(2018) Sophia Hsin-Jung Li et al.   Nature Microbiology

Absolute Quantification of ppGpp and pppGpp by Double-Spike Isotope Dilution Ion Chromatography–High-Resolution Mass Spectrometry

(2018) Clément Patacq et al.   ANALYTICAL CHEMISTRY

Superoxide dismutase activity confers (p)ppGpp-mediated antibiotic tolerance to stationary-phase Pseudomonas aeruginosa

(2018) Dorival Martins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Affinity-based capture and identification of protein effectors of the growth regulator ppGpp

(2018) Boyuan Wang et al.   Nature Chemical Biology

The stringent response promotes biofilm dispersal in Pseudomonas putida

(2017) Carlos Díaz-Salazar et al.   Scientific Reports

Synthetic Peptides to Target Stringent Response-Controlled Virulence in a Pseudomonas aeruginosa Murine Cutaneous Infection Model

(2017) Daniel Pletzer et al.   Frontiers in Microbiology

Role of ppGpp in Pseudomonas aeruginosa acute pulmonary infection and virulence regulation

(2016) Xiaohui Xu et al.   MICROBIOLOGICAL RESEARCH

ppGpp Binding to a Site at the RNAP-DksA Interface Accounts for Its Dramatic Effects on Transcription Initiation during the Stringent Response

(2016) Wilma Ross et al.   MOLECULAR CELL

ppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-positive bacteria

(2016) Rebecca M. Corrigan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial Abscess Formation Is Controlled by the Stringent Stress Response and Can Be Targeted Therapeutically

(2016) Sarah C. Mansour et al.   EBioMedicine

Contribution of Stress Responses to Antibiotic Tolerance in Pseudomonas aeruginosa Biofilms

(2015) Philip S. Stewart et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pseudomonas putidaKT2440 Strain Metabolizes Glucose through a Cycle Formed by Enzymes of the Entner-Doudoroff, Embden-Meyerhof-Parnas, and Pentose Phosphate Pathways

(2015) Pablo I. Nikel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Obg and Membrane Depolarization Are Part of a Microbial Bet-Hedging Strategy that Leads to Antibiotic Tolerance

(2015) Natalie Verstraeten et al.   MOLECULAR CELL

Recent functional insights into the role of (p)ppGpp in bacterial physiology

(2015) Vasili Hauryliuk et al.   NATURE REVIEWS MICROBIOLOGY

Antibiotic efficacy is linked to bacterial cellular respiration

(2015) Michael A. Lobritz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sampling of intracellular metabolites for stationary and non-stationary 13C metabolic flux analysis in Escherichia coli

(2014) Pierre Millard et al.   ANALYTICAL BIOCHEMISTRY

Structural and Functional Insights into the Mode of Action of a Universally Conserved Obg GTPase

(2014) Boya Feng et al.   PLOS BIOLOGY

The Stringent Response Controls Catalases in Pseudomonas aeruginosa and Is Required for Hydrogen Peroxide and Antibiotic Tolerance

(2013) M. Khakimova et al.   JOURNAL OF BACTERIOLOGY

Conserved Pyridoxal Protein That Regulates Ile and Val Metabolism

(2013) T. Ito et al.   JOURNAL OF BACTERIOLOGY

Basal Levels of (p)ppGpp in Enterococcus faecalis: the Magic beyond the Stringent Response

(2013) A. O. Gaca et al.   mBio

Crystal structure analysis of the translation factor RF3 (release factor 3)

(2012) Kiyohito Kihira et al.   FEBS LETTERS

Direct Regulation of GTP Homeostasis by (p)ppGpp: A Critical Component of Viability and Stress Resistance

(2012) Allison Kriel et al.   MOLECULAR CELL

The Stringent Response Is Essential for Pseudomonas aeruginosa Virulence in the Rat Lung Agar Bead and Drosophila melanogaster Feeding Models of Infection

(2011) Stefanie L. Vogt et al.   INFECTION AND IMMUNITY

Active Starvation Responses Mediate Antibiotic Tolerance in Biofilms and Nutrient-Limited Bacteria

(2011) D. Nguyen et al.   SCIENCE

6S RNA regulation of relA alters ppGpp levels in early stationary phase

(2010) A. T. Cavanagh et al.   MICROBIOLOGY-SGM