A Carboxyl Ester Lipase (CEL) Mutant Causes Chronic Pancreatitis by Forming Intracellular Aggregates That Activate Apoptosis

No Association Between CEL–HYB Hybrid Allele and Chronic Pancreatitis in Asian Populations

(2016) Wen-Bin Zou et al.   GASTROENTEROLOGY

A novel mutation in PNLIP causes pancreatic triglyceride lipase deficiency through protein misfolding

(2015) András Szabó et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Exposure to Radiocontrast Agents Induces Pancreatic Inflammation by Activation of Nuclear Factor-κB, Calcium Signaling, and Calcineurin

(2015) Shunqian Jin et al.   GASTROENTEROLOGY

Induced pluripotent stem cells model personalized variations in liver disease resulting from α1-antitrypsin deficiency

(2015) Edgar N. Tafaleng et al.   HEPATOLOGY

A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis

(2015) Karianne Fjeld et al.   NATURE GENETICS

Unfolded protein response is activated in Lewy body dementias

(2015) Jean-Ha Baek et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Endocytosis of Secreted Carboxyl Ester Lipase in a Syndrome of Diabetes and Pancreatic Exocrine Dysfunction

(2014) Janniche Torsvik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic Reticulum Stress Is Chronically Activated in Chronic Pancreatitis

(2014) Raghuwansh P. Sah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

When ER stress reaches a dead end

(2013) Hery Urra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Variants in CPA1 are strongly associated with early onset chronic pancreatitis

(2013) Heiko Witt et al.   NATURE GENETICS

The role of protein synthesis and digestive enzymes in acinar cell injury

(2013) Craig D. Logsdon et al.   Nature Reviews Gastroenterology & Hepatology

The number of tandem repeats in the carboxyl-ester lipase (CEL) gene as a risk factor in alcoholic and idiopathic chronic pancreatitis

(2013) Anja Ragvin et al.   PANCREATOLOGY

Absence of Diabetes and Pancreatic Exocrine Dysfunction in a Transgenic Model of Carboxyl-Ester Lipase-MODY (Maturity-Onset Diabetes of the Young)

(2013) Helge Ræder et al.   PLoS One

Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk

(2012) Sebastian Beer et al.   GUT

Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, acinar cell damage, and systemic inflammation in acute pancreatitis

(2011) Ersin Seyhun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Digesting New Information About the Role of Trypsin in Pancreatitis

(2011) Baoan Ji et al.   GASTROENTEROLOGY

Pancreatic Lipase-related Protein-2 (PLRP2) Can Contribute to Dietary Fat Digestion in Human Newborns

(2011) Xunjun Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diabetes and Pancreatic Exocrine Dysfunction Due to Mutations in the Carboxyl Ester Lipase Gene-Maturity Onset Diabetes of the Young (CEL-MODY)

(2011) Bente B. Johansson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Environmental and Genetic Stressors and the Unfolded Protein Response in Exocrine Pancreatic Function – A Hypothesis

(2011) Stephen J. Pandol et al.   Frontiers in Physiology

Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cells

(2009) R. Szmola et al.   GUT

Mutations in the VNTR of the carboxyl-ester lipase gene (CEL) are a rare cause of monogenic diabetes

(2009) Janniche Torsvik et al.   HUMAN GENETICS

Hereditary pancreatitis caused by mutation-induced misfolding of human cationic trypsinogen: A novel disease mechanism

(2009) Éva Kereszturi et al.   HUMAN MUTATION

Neurological Features and Enzyme Therapy in Patients With Endocrine and Exocrine Pancreas Dysfunction Due to CEL Mutations

(2008) M. Vesterhus et al.   DIABETES CARE

Endoplasmic reticulum stress and the pancreatic acinar cell

(2008) Constanze H Kubisch et al.   Expert Review of Gastroenterology & Hepatology