Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk

CFTR,SPINK1,CTRCandPRSS1variants in chronic pancreatitis: is the role of mutatedCFTRoverestimated?

(2012) Jonas Rosendahl et al.   GUT

Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants

(2012) Sumit Paliwal et al.   GUT

Increased Activation of Hereditary Pancreatitis-associated Human Cationic Trypsinogen Mutants in Presence of Chymotrypsin C

(2012) András Szabó et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetics of Pancreatitis: A Guide for Clinicians

(2011) Heiko Witt   DIGESTIVE DISEASES

Asparagine-linked glycosylation of human chymotrypsin C is required for folding and secretion but not for enzyme activity

(2011) Melinda Bence et al.   FEBS Journal

High Affinity Small Protein Inhibitors of Human Chymotrypsin C (CTRC) Selected by Phage Display Reveal Unusual Preference for P4′ Acidic Residues

(2011) András Szabó et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chymotrypsin C mutations in chronic pancreatitis

(2011) Jiayi Zhou et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Genetic Aspects of Pancreatitis

(2010) David C. Whitcomb   Annual Review of Medicine

Multifactorial Genesis of Pancreatitis in Primary Hyperparathyroidism: Evidence for “Protective” (PRSS2) and “Destructive” (CTRC) Genetic Factors

(2010) P. Felderbauer et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Chronic Pancreatitis: Genetics and Pathogenesis

(2009) Jian-Min Chen et al.   Annual Review of Genomics and Human Genetics

Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants

(2009) Monique H.M. Derikx et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cells

(2009) R. Szmola et al.   GUT

Hereditary pancreatitis caused by mutation-induced misfolding of human cationic trypsinogen: A novel disease mechanism

(2009) Éva Kereszturi et al.   HUMAN MUTATION

Association of Novel Chymotrypsin C Gene Variations and Haplotypes in Patients with Chronic Pancreatitis in Chinese in Taiwan

(2009) Ming-Chu Chang et al.   PANCREATOLOGY

Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis

(2008) Emmanuelle Masson et al.   HUMAN GENETICS