Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, fromMycobacterium tuberculosis

Structure and Mechanism of the Caseinolytic Protease ClpP1/2 Heterocomplex fromListeria monocytogenes

(2015) Maria Dahmen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cleavage Specificity ofMycobacterium tuberculosisClpP1P2 Protease and Identification of Novel Peptide Substrates and Boronate Inhibitors with Anti-bacterial Activity

(2015) Tatos Akopian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1

(2015) Julia Leodolter et al.   PLoS One

The Cyclic Peptide Ecumicin Targeting ClpC1 Is Active against Mycobacterium tuberculosis In Vivo

(2014) Wei Gao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2

(2014) Ekaterina Gavrish et al.   CHEMISTRY & BIOLOGY

Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery

(2014) K. R. Schmitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Helix Unfolding/Refolding Characterizes the Functional Dynamics ofStaphylococcus aureusClp Protease

(2013) Fei Ye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The active ClpP protease fromM. tuberculosisis a complex composed of a heptameric ClpP1 and a ClpP2 ring

(2012) Tatos Akopian et al.   EMBO JOURNAL

Insights into Structural Network Responsible for Oligomerization and Activity of Bacterial Virulence Regulator Caseinolytic Protease P (ClpP) Protein

(2012) Malte Gersch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mycobacterium tuberculosis ClpP1 and ClpP2 Function Together in Protein Degradation and Are Required for Viability in vitro and During Infection

(2012) Ravikiran M. Raju et al.   PLoS Pathogens

A Conformational Switch Underlies ClpP Protease Function

(2011) Sebastian R. Geiger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Assembly and proteolytic processing of mycobacterial ClpP1 and ClpP2

(2011) Nadia Benaroudj et al.   BMC BIOCHEMISTRY

Single-Molecule Protein Unfolding and Translocation by an ATP-Fueled Proteolytic Machine

(2011) Marie-Eve Aubin-Tam et al.   CELL

ClpX(P) Generates Mechanical Force to Unfold and Translocate Its Protein Substrates

(2011) Rodrigo A. Maillard et al.   CELL

Validation of the Essential ClpP Protease in Mycobacterium tuberculosis as a Novel Drug Target

(2011) J. Ollinger et al.   JOURNAL OF BACTERIOLOGY

Structural Switching ofStaphylococcus aureusClp Protease

(2011) Jie Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptome analysis reveals that ClpXP proteolysis controls key virulence properties of Streptococcus mutans

(2011) J. K. Kajfasz et al.   MICROBIOLOGY-SGM

Structural insights into the conformational diversity of ClpP from Bacillus subtilis

(2011) Byung-Gil Lee et al.   MOLECULES AND CELLS

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Acyldepsipeptide Antibiotics Induce the Formation of a Structured Axial Channel in ClpP: A Model for the ClpX/ClpA-Bound State of ClpP

(2010) Dominic Him Shun Li et al.   CHEMISTRY & BIOLOGY

Binding of the ClpA Unfoldase Opens the Axial Gate of ClpP Peptidase

(2010) Grégory Effantin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism

(2010) Byung-Gil Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease

(2009) Janine Kirstein et al.   EMBO Molecular Medicine

HslVU ATP-dependent Protease Utilizes Maximally Six among Twelve Threonine Active Sites during Proteolysis

(2009) Jung Wook Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Turned on for degradation: ATPase-independent degradation by ClpP

(2008) Maria C. Bewley et al.   JOURNAL OF STRUCTURAL BIOLOGY