The R838S Mutation in Retinal Guanylyl Cyclase 1 (RetGC1) Alters Calcium Sensitivity of cGMP Synthesis in the Retina and Causes Blindness in Transgenic Mice

Functional Study and Mapping Sites for Interaction with the Target Enzyme in Retinal Degeneration 3 (RD3) Protein

(2016) Igor V. Peshenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene Therapy Fully Restores Vision to the All-ConeNrl−/−Gucy2e−/−Mouse Model of Leber Congenital Amaurosis-1

(2015) Sanford L. Boye et al.   HUMAN GENE THERAPY

Dimerization Domain of Retinal Membrane Guanylyl Cyclase 1 (RetGC1) Is an Essential Part of Guanylyl Cyclase-activating Protein (GCAP) Binding Interface

(2015) Igor V. Peshenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluating the Role of Retinal Membrane Guanylyl Cyclase 1 (RetGC1) Domains in Binding Guanylyl Cyclase-activating Proteins (GCAPs)

(2015) Igor V. Peshenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice

(2015) Hongwei Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein and Signaling Networks in Vertebrate Photoreceptor Cells

(2015) Karl-Wilhelm Koch et al.   Frontiers in Molecular Neuroscience

Whole Exome Sequencing Reveals GUCY2D as a Major Gene Associated With Cone and Cone-Rod Dystrophy in Israel

(2014) C. H. Lazar et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Identification of Target Binding Site in Photoreceptor Guanylyl Cyclase-activating Protein 1 (GCAP1)

(2014) Igor V. Peshenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired Association of Retinal Degeneration-3 with Guanylate Cyclase-1 and Guanylate Cyclase-activating Protein-1 Leads to Leber Congenital Amaurosis-1

(2014) Rahel Zulliger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into the role of RD3 in guanylate cyclase trafficking, photoreceptor degeneration, and Leber congenital amaurosis

(2014) Laurie L. Molday et al.   Frontiers in Molecular Neuroscience

The Dimerization Domain in Outer Segment Guanylate Cyclase Is a Ca2+-Sensitive Control Switch Module

(2013) Patrick Zägel et al.   BIOCHEMISTRY

Transgenic zebrafish expressing mutant human RETGC-1 exhibit aberrant cone and rod morphology

(2013) Ross F. Collery et al.   EXPERIMENTAL EYE RESEARCH

RD3 gene delivery restores guanylate cyclase localization and rescues photoreceptors in the Rd3 mouse model of Leber congenital amaurosis 12

(2013) L. L. Molday et al.   HUMAN MOLECULAR GENETICS

cGMP Accumulation Causes Photoreceptor Degeneration in CNG Channel Deficiency: Evidence of cGMP Cytotoxicity Independently of Enhanced CNG Channel Function

(2013) J. Xu et al.   JOURNAL OF NEUROSCIENCE

AAV-Mediated Gene Therapy in the Guanylate Cyclase (RetGC1/RetGC2) Double Knockout Mouse Model of Leber Congenital Amaurosis

(2012) Sanford L. Boye et al.   HUMAN GENE THERAPY

Determining consequences of retinal membrane guanylyl cyclase (RetGC1) deficiency in human Leber congenital amaurosis en route to therapy: residual cone-photoreceptor vision correlates with biochemical properties of the mutants

(2012) Samuel G. Jacobson et al.   HUMAN MOLECULAR GENETICS

Retinal Guanylyl Cyclase Isozyme 1 Is the Preferential In Vivo Target for Constitutively Active GCAP1 Mutants Causing Congenital Degeneration of Photoreceptors

(2012) E. V. Olshevskaya et al.   JOURNAL OF NEUROSCIENCE

Enzymatic Relay Mechanism Stimulates Cyclic GMP Synthesis in Rod Photoresponse: Biochemical and Physiological Study in Guanylyl Cyclase Activating Protein 1 Knockout Mice

(2012) Clint L. Makino et al.   PLoS One

Retinal Degeneration 3 (RD3) Protein Inhibits Catalytic Activity of Retinal Membrane Guanylyl Cyclase (RetGC) and Its Stimulation by Activating Proteins

(2011) Igor V. Peshenko et al.   BIOCHEMISTRY

Enzymatic Properties and Regulation of the Native Isozymes of Retinal Membrane Guanylyl Cyclase (RetGC) from Mouse Photoreceptors

(2011) Igor V. Peshenko et al.   BIOCHEMISTRY

Long-Term Preservation of Cones and Improvement in Visual Function Following Gene Therapy in a Mouse Model of Leber Congenital Amaurosis Caused by Guanylate Cyclase-1 Deficiency

(2011) Marija Mihelec et al.   HUMAN GENE THERAPY

Photoreceptor Signaling: Supporting Vision across a Wide Range of Light Intensities

(2011) Vadim Y. Arshavsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Guanylyl Cyclase Modulation in Mouse Cone Phototransduction

(2011) K. Sakurai et al.   JOURNAL OF NEUROSCIENCE

Differential Calcium Signaling by Cone Specific Guanylate Cyclase-Activating Proteins from the Zebrafish Retina

(2011) Alexander Scholten et al.   PLoS One

Activation of Retinal Guanylyl Cyclase RetGC1 by GCAP1: Stoichiometry of Binding and Effect of New LCA-Related Mutations

(2010) Igor V. Peshenko et al.   BIOCHEMISTRY

Functional and Behavioral Restoration of Vision by Gene Therapy in the Guanylate Cyclase-1 (GC1) Knockout Mouse

(2010) Shannon E. Boye et al.   PLoS One

RD3, the protein associated with Leber congenital amaurosis type 12, is required for guanylate cyclase trafficking in photoreceptor cells

(2010) S. Azadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phototransduction Motifs and Variations

(2009) King-Wai Yau et al.   CELL

Guanylate cyclases and associated activator proteins in retinal disease

(2009) David M. Hunt et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Mg2+/Ca2+ cation binding cycle of guanylyl cyclase activating proteins (GCAPs): role in regulation of photoreceptor guanylyl cyclase

(2009) Alexander M. Dizhoor et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

A Role for GCAP2 in Regulating the Photoresponse

(2008) Clint L. Makino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY