Suppression of human and simian immunodeficiency virus replication with the CCR5-specific antibody Leronlimab in two species

Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission

(2021) Xiao L. Chang et al.   Nature Communications

CCR5 Receptor Occupancy Analysis Reveals Increased Peripheral Blood CCR5+CD4+ T Cells Following Treatment With the Anti-CCR5 Antibody Leronlimab

(2021) Xiao L. Chang et al.   Frontiers in Immunology

Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity

(2020) Mariya B. Shapiro et al.   Nature Communications

Heterogeneous antiretroviral drug distribution and HIV/SHIV detection in the gut of three species

(2019) Corbin G. Thompson et al.   Science Translational Medicine

Anti-PD-1 monoclonal antibody MEDI0680 in a phase I study of patients with advanced solid malignancies

(2019) Aung Naing et al.   Journal for ImmunoTherapy of Cancer

Broadly neutralizing antibodies for the treatment and prevention of HIV infection

(2019) Marina Caskey   Current Opinion in HIV and AIDS

PRO 140, a monoclonal antibody targeting CCR5, as a long-acting, single-agent maintenance therapy for HIV-1 infection

(2018) Kush Dhody et al.   HIV CLINICAL TRIALS

The return of PRO 140, a CCR5-directed mAb

(2018) Melanie A. Thompson   Current Opinion in HIV and AIDS

Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1–infected individuals

(2018) Mathieu Uzzan et al.   Science Translational Medicine

Gene Editing of HIV-1 Co-receptors to Prevent and/or Cure Virus Infection

(2018) Alexander G. Allen et al.   Frontiers in Microbiology

Impact of HIV Drug Resistance on HIV/AIDS-Associated Mortality, New Infections, and Antiretroviral Therapy Program Costs in Sub–Saharan Africa

(2017) Andrew N Phillips et al.   JOURNAL OF INFECTIOUS DISEASES

Antibody 10-1074 suppresses viremia in HIV-1-infected individuals

(2017) Marina Caskey et al.   NATURE MEDICINE

Dolutegravir as maintenance monotherapy for HIV (DOMONO): a phase 2, randomised non-inferiority trial

(2017) Ingeborg Wijting et al.   Lancet HIV

Survival of HIV-positive patients starting antiretroviral therapy between 1996 and 2013: a collaborative analysis of cohort studies

(2017) Adam Trickey et al.   Lancet HIV

Viral blips during suppressive antiretroviral treatment are associated with high baseline HIV-1 RNA levels

(2016) Erik Sörstedt et al.   BMC INFECTIOUS DISEASES

Diversity and Tropism of HIV-1 Rebound Virus Populations in Plasma Level After Treatment Discontinuation

(2016) Maria M. Bednar et al.   JOURNAL OF INFECTIOUS DISEASES

Persistent HIV-1 replication during antiretroviral therapy

(2016) Javier Martinez-Picado et al.   Current Opinion in HIV and AIDS

A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals

(2015) Francesco Andrea Procopio et al.   EBioMedicine

Why primate models matter

(2014) Kimberley A. Phillips et al.   AMERICAN JOURNAL OF PRIMATOLOGY

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Dependence on the CCR5 Coreceptor for Viral Replication Explains the Lack of Rebound of CXCR4-Predicted HIV Variants in the Berlin Patient

(2014) Jori Symons et al.   CLINICAL INFECTIOUS DISEASES

IgG Subclasses and Allotypes: From Structure to Effector Functions

(2014) Gestur Vidarsson et al.   Frontiers in Immunology

Immune clearance of highly pathogenic SIV infection

(2013) Scott G. Hansen et al.   NATURE

Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys

(2013) Dan H. Barouch et al.   NATURE

LabKey Server: An open source platform for scientific data integration, analysis and collaboration

(2011) Elizabeth K Nelson et al.   BMC BIOINFORMATICS

Breaking Free of Sample Size Dogma to Perform Innovative Translational Research

(2011) P. Bacchetti et al.   Science Translational Medicine

Phase 2a Study of the CCR5 Monoclonal Antibody PRO 140 Administered Intravenously to HIV-Infected Adults

(2010) J. M. Jacobson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fast and accurate long-read alignment with Burrows–Wheeler transform

(2010) Heng Li et al.   BIOINFORMATICS

Whole-Genome Characterization of Human and Simian Immunodeficiency Virus Intrahost Diversity by Ultradeep Pyrosequencing

(2010) B. N. Bimber et al.   JOURNAL OF VIROLOGY

A Maraviroc-Resistant HIV-1 with Narrow Cross-Resistance to Other CCR5 Antagonists Depends on both N-Terminal and Extracellular Loop Domains of Drug-Bound CCR5

(2010) John C. Tilton et al.   JOURNAL OF VIROLOGY

Ultradeep Pyrosequencing Detects Complex Patterns of CD8+ T-Lymphocyte Escape in Simian Immunodeficiency Virus-Infected Macaques

(2009) B. N. Bimber et al.   JOURNAL OF VIROLOGY

Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation

(2009) Gero Hütter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antiviral Activity of Single‐Dose PRO 140, a CCR5 Monoclonal Antibody, in HIV‐Infected Adults

(2008) Jeffrey M. Jacobson et al.   JOURNAL OF INFECTIOUS DISEASES

Different Mutational Pathways to CXCR4 Coreceptor Switch of CCR5-Using Simian-Human Immunodeficiency Virus

(2008) S.-h. Ho et al.   JOURNAL OF VIROLOGY